{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:08:03Z","timestamp":1786122483666,"version":"3.56.0"},"reference-count":178,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["22K18936"],"award-info":[{"award-number":["22K18936"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["23H01821"],"award-info":[{"award-number":["23H01821"]}]},{"name":"Research Center for Biomedical Engineering at Tokyo Medical and Dental University","award":["22K18936"],"award-info":[{"award-number":["22K18936"]}]},{"name":"Research Center for Biomedical Engineering at Tokyo Medical and Dental University","award":["23H01821"],"award-info":[{"award-number":["23H01821"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody\/antigen complementarity. Because of their specificity, MIPs can be included in sensors as a recognition element coupled to a transducer part that converts the interaction of MIP\/analyte into a quantifiable signal. Such sensors have important applications in the biomedical field in diagnosis and drug discovery, and are a necessary complement of tissue engineering for analyzing the functionalities of the engineered tissues. Therefore, in this review, we provide an overview of MIP sensors that have been used for the detection of skeletal- and cardiac-muscle-related analytes. We organized this review by targeted analytes in alphabetical order. Thus, after an introduction to the fabrication of MIPs, we highlight different types of MIP sensors with an emphasis on recent works and show their great diversity, their fabrication, their linear range for a given analyte, their limit of detection (LOD), specificity, and reproducibility. We conclude the review with future developments and perspectives.<\/jats:p>","DOI":"10.3390\/s23125625","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:54:33Z","timestamp":1686884073000},"page":"5625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes"],"prefix":"10.3390","volume":"23","author":[{"given":"Serge","family":"Ostrovidov","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugan","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 31116, Republic of Korea"},{"name":"Department of Nanobiomedical Science, BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea"},{"name":"Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of Korea"},{"name":"UCL Eastman-Korea Dental Medicine Innovation Center, Dankook University, Cheonan 31116, Republic of Korea"},{"name":"School of Basic Medical Science, Institute for Advanced Study, Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610106, China"},{"name":"Department of Metallurgical and Materials Engineering, Atilim University, 06830 Ankara, Turkey"},{"name":"School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, China"},{"name":"Institute of Precision Medicine, Medical and Life Sciences Faculty, Furtwangen University, 78054 Villingen-Schwennigen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojae","family":"Bae","sequence":"additional","affiliation":[{"name":"KU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorka","family":"Orive","sequence":"additional","affiliation":[{"name":"NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV\/EHU, 01006 Vitoria-Gasteiz, Spain"},{"name":"Bioaraba, NanoBioCel Research Group, 01009 Vitoria-Gasteiz, Spain"},{"name":"Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 01006 Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Fujie","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan"},{"name":"Living System Materialogy (LiSM) Research Group, International Research Frontiers Initiative (IRFI), Tokyo Institute of Technology, Yokohama 226-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nashimoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Shi","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-4172","authenticated-orcid":false,"given":"Hirokazu","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.coelec.2017.11.018","article-title":"Recent advances in electrochemical sensors based on chiral and nano-sized imprinted polymers","volume":"7","author":"Canfarotta","year":"2018","journal-title":"Curr. 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