{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:41:01Z","timestamp":1760128861131,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"MINCIENCIAS","doi-asserted-by":"publisher","award":["115077757186"],"award-info":[{"award-number":["115077757186"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Cutaneous leishmaniasis (CL) is a neglected disease caused by an intracellular parasite of the Leishmania genus. CL lacks tools that allow its understanding and treatment follow-up. This article presents the use of metrical and optical tools for the analysis of the temporal evolution of treated skin ulcers caused by CL in an animal model. Leishmania braziliensis and L. panamensis were experimentally inoculated in golden hamsters, which were treated with experimental and commercial drugs. The temporal evolution was monitored by means of ulcers\u2019 surface areas, as well as absorption and scattering optical parameters. Ulcers\u2019 surface areas were obtained via photogrammetry, which is a procedure that allowed for 3D modeling of the ulcer using specialized software. Optical parameters were obtained from a spectroscopy study, representing the cutaneous tissue\u2019s biological components. A one-way ANOVA analysis was conducted to identify relationships between both the ulcers\u2019 areas and optical parameters. As a result, ulcers\u2019 surface areas were found to be related to the following optical parameters: epidermis thickness, collagen, keratinocytes, volume-fraction of blood, and oxygen saturation. This study is a proof of concept that shows that optical parameters could be associated with metrical ones, giving a more reliable concept during the assessment of a skin ulcer\u2019s healing.<\/jats:p>","DOI":"10.3390\/s23135861","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:28:02Z","timestamp":1687757282000},"page":"5861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Evaluation of the Surface Area of Treated Skin Ulcers Caused by Cutaneous Leishmaniasis and Relation with Optical Parameters in an Animal Model: A Proof of Concept"],"prefix":"10.3390","volume":"23","author":[{"given":"Sergio","family":"Londo\u00f1o","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica, Instituto Tecnol\u00f3gico Metropolitano, Medell\u00edn 050034, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Viloria","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica, Instituto Tecnol\u00f3gico Metropolitano, Medell\u00edn 050034, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-0965","authenticated-orcid":false,"given":"Sandra","family":"P\u00e9rez-Buitrago","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Dispositivos M\u00e9dicos, Departamento de Ingenier\u00eda, Pontificia Universidad Cat\u00f3lica del Per\u00fa, Lima 15088, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Murillo","sequence":"additional","affiliation":[{"name":"Programa de Estudio y Control de Enfermedades Tropicales\u2014PECET, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deivid","family":"Botina","sequence":"additional","affiliation":[{"name":"Laboratoire ImViA, Universit\u00e9 de Bourgogne, BP 47870, 21078 Dijon Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Zarzycki","sequence":"additional","affiliation":[{"name":"Independent Researcher, Envigado 055422, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnson","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de \u00d3ptica y Espectroscop\u00eda, Universidad Pontificia Bolivariana, Medell\u00edn 050031, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-2459","authenticated-orcid":false,"given":"Maria C.","family":"Torres-Madronero","sequence":"additional","affiliation":[{"name":"Research Group on Smart Machine and Pattern Recognition, MIRP Laboratory, Instituto Tecnol\u00f3gico Metropolitano, Medell\u00edn 050013, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-4931","authenticated-orcid":false,"given":"Sara M.","family":"Robledo","sequence":"additional","affiliation":[{"name":"Programa de Estudio y Control de Enfermedades Tropicales\u2014PECET, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-1565","authenticated-orcid":false,"given":"Franck","family":"Marzani","sequence":"additional","affiliation":[{"name":"Laboratoire ImViA, Universit\u00e9 de Bourgogne, BP 47870, 21078 Dijon Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-9964","authenticated-orcid":false,"given":"Sylvie","family":"Treuillet","sequence":"additional","affiliation":[{"name":"Laboratoire Pluridisciplinaire de Recherche Ing\u00e9nierie des Syst\u00e8mes, M\u00e9canique, \u00c9nerg\u00e9tique\u2014PRISME, Universit\u00e9 d\u2019Orl\u00e9ans, 45072 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1913-0636","authenticated-orcid":false,"given":"Benjamin","family":"Castaneda","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Dispositivos M\u00e9dicos, Departamento de Ingenier\u00eda, Pontificia Universidad Cat\u00f3lica del Per\u00fa, Lima 15088, Peru"},{"name":"Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"July","family":"Galeano","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Materiales Avanzados y Energ\u00eda MatyEr, Instituto Tecnol\u00f3gico Metropolitano, Medell\u00edn 050013, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"ref_1","unstructured":"(2022, September 05). 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