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However, as taste and odor molecules perceived by the tongue and nose are chemical phenomena, it has been difficult to express them as objective and univocal digital data, since no reference chemicals can be defined. Therefore, while the recording, saving, transmitting to remote locations, and replaying of human visual, auditory, and tactile information as digital data in digital devices have been realized (this series of data flow is defined as DX (digital transformation) in this review), the DX of human taste and odor information is not yet in the realization stage. Particularly, since there are at least 400,000 types of odor molecules and an infinite number of complex odors that are mixtures of these molecules, it has been considered extremely difficult to realize \u201chuman olfactory DX\u201d by converting all odors perceived by human olfaction into digital data. In this review, we discuss the current status and future prospects of the development of \u201chuman olfactory DX\u201d, which we believe can be realized by utilizing odor sensors that employ the olfactory receptors (ORs) that support human olfaction as sensing molecules (i.e., human OR sensor).<\/jats:p>","DOI":"10.3390\/s23136164","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:54:41Z","timestamp":1688604881000},"page":"6164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Human Olfactory Receptor Sensor for Odor Reconstitution"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5432-7274","authenticated-orcid":false,"given":"Shun\u2019ichi","family":"Kuroda","sequence":"first","affiliation":[{"name":"Department of Biomolecular Science and Reaction, SANKEN, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan"},{"name":"R&D Center, Komi-Hakko Corp, 3F Osaka University Technoalliance C Bldg, 2-8 Yamadaoka, Suita, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakaya-Kishi","sequence":"additional","affiliation":[{"name":"R&D Center, Komi-Hakko Corp, 3F Osaka University Technoalliance C Bldg, 2-8 Yamadaoka, Suita, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tatematsu","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Science and Reaction, SANKEN, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan"},{"name":"R&D Center, Komi-Hakko Corp, 3F Osaka University Technoalliance C Bldg, 2-8 Yamadaoka, Suita, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1893-6942","authenticated-orcid":false,"given":"Shuji","family":"Hinuma","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Science and Reaction, SANKEN, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bios.2018.08.072","article-title":"Highly sensitive olfactory biosensors for the detection of volatile organic compounds by surface plasmon resonance imaging","volume":"123","author":"Hurot","year":"2019","journal-title":"Biosens. 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