{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:22:27Z","timestamp":1760149347401,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013128","name":"Korea Technology and Information Promotion Agency for SMEs","doi-asserted-by":"publisher","award":["S3275392","GCU-202205980001","K_G012001187801"],"award-info":[{"award-number":["S3275392","GCU-202205980001","K_G012001187801"]}],"id":[{"id":"10.13039\/501100013128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002631","name":"Gachon University","doi-asserted-by":"publisher","award":["S3275392","GCU-202205980001","K_G012001187801"],"award-info":[{"award-number":["S3275392","GCU-202205980001","K_G012001187801"]}],"id":[{"id":"10.13039\/501100002631","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Innovation Program","award":["S3275392","GCU-202205980001","K_G012001187801"],"award-info":[{"award-number":["S3275392","GCU-202205980001","K_G012001187801"]}]},{"name":"Ministry of Trade, Industry &amp; Energy(MOTIE, Korea)","award":["S3275392","GCU-202205980001","K_G012001187801"],"award-info":[{"award-number":["S3275392","GCU-202205980001","K_G012001187801"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>After surgery for ovarian cancer or colorectal cancer, residual tumors are left around. A practical way to treat residual tumors is to destroy them with heat by injecting high-temperature drugs into the abdominal cavity. The injected medicinal substances are induced to flow out of the abdominal cavity; then, the spilled drug flows back into the abdominal cavity through feedback. During this process, the heat starts to decrease; thus, the treatment performance reduces. To overcome this problem, this study compares and assesses the temperature needed to maintain the heat for treatment and transmits a command signal to the heat exchanger through a look-up table (LUT). When the temperature decreases during the circulation of medications leaking out of the abdominal cavity, the LUT transmits a control signal (Tp) to the heat exchanger, which increases or vice versa. However, if the temperature (To) is within the treatment range, the LUT sends a Ts signal to the heat exchanger. This principle generates a pulse signal for the temperature difference (Tdif) in TC by comparing and determining the temperature (To) of the substance flowing out of the abdominal cavity with the reference temperature (Tref) through the temperature comparator (TC). At this time, if the signal is 41 \u00b0C or less, the LUT generates (heats) a Tp signal so that the temperature of the heat exchanger can be maintained in the range of 41 \u00b0C to 43 \u00b0C. If the Tdif is 44 \u00b0C or higher, the LUT generates (cools) the Ta signal and maintains the temperature of the heat exchanger at 41\u201343 \u00b0C. If the Tdif is maintained at 41\u201343 \u00b0C, the LUT generates a Tx signal to stop the system performance. At this time, the TC operation performance and Tdif generation process for comparing and determining the signal of To and Tref for drugs leaking out of the abdominal cavity is very important. It was observed that the faster the response signal, the lower the comparison and judgment error was; therefore, the response signal was confirmed to be 0.209 \u03bcs. The proposed method can guarantee rapid\/accurate\/safe treatment and automatically induce temperature adjustment; thus, it could be applied to the field of surgery.<\/jats:p>","DOI":"10.3390\/s23156722","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T02:10:45Z","timestamp":1690510245000},"page":"6722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Design of an Automatic Temperature Compensation System through Smart Heat Comparison\/Judgment and Control for Stable Thermal Treatment in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Surgery"],"prefix":"10.3390","volume":"23","author":[{"given":"Kicheol","family":"Yoon","sequence":"first","affiliation":[{"name":"Medical Devices R&D Center, Gachon University Gil Medical Center, 21, 774 Beon-gil, Namdong-daero, Namdong-gu, Incheon 21565, Republic of Korea"},{"name":"Department of Biomedical Engineering, College of Medicine, Gachon University, 38\u201313, 3 Beon-gil, Dokjom-ro 3, Namdong-gu, Incheon 21565, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Devices R&D Center, Gachon University Gil Medical Center, 21, 774 Beon-gil, Namdong-daero, Namdong-gu, Incheon 21565, Republic of Korea"},{"name":"Department of Biomedical Engineering, College of Medicine, Gachon University, 38\u201313, 3 Beon-gil, Dokjom-ro 3, Namdong-gu, Incheon 21565, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Gyeonggi University of Science and Technology, Gyeonggigwagi-dearo 269, Siheung City 15073, Gyeonggi-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9714-6038","authenticated-orcid":false,"given":"Kwang Gi","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Devices R&D Center, Gachon University Gil Medical Center, 21, 774 Beon-gil, Namdong-daero, Namdong-gu, Incheon 21565, Republic of Korea"},{"name":"Department of Biomedical Engineering, College of Medicine, Gachon University, 38\u201313, 3 Beon-gil, Dokjom-ro 3, Namdong-gu, Incheon 21565, Republic of Korea"},{"name":"Department of Biomedical Engineering, College of Health Science, Gachon University, 191 Hambak-moero, Yeonsu-gu, Incheon 21936, Republic of Korea"},{"name":"Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Gachon University, 38\u201313, 3 Beon-gil, Dokjom-ro, Namdong-gu, Incheon 21565, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4143\/crt.2020.206","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2017","volume":"52","author":"Hong","year":"2020","journal-title":"Cancer Res. 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