{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:14:57Z","timestamp":1774408497229,"version":"3.50.1"},"reference-count":64,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education and Science of the Russian Federation","award":["075-15-2021-933"],"award-info":[{"award-number":["075-15-2021-933"]}]},{"name":"Ministry of Education and Science of the Russian Federation","award":["RF00121X0004"],"award-info":[{"award-number":["RF00121X0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Prostate cancer (PC) is one of the major causes of death among elderly men. PC is often diagnosed later in progression due to asymptomatic early stages. Early detection of PC is thus crucial for effective PC treatment. The aim of this study is the simultaneous highly sensitive detection of a palette of PC-associated microRNAs (miRNAs) in human plasma samples. With this aim, a nanoribbon biosensor system based on \u201csilicon-on-insulator\u201d structures (SOI-NR biosensor) has been employed. In order to provide biospecific detection of the target miRNAs, the surface of individual nanoribbons has been sensitized with DNA oligonucleotide probes (oDNA probes) complementary to the target miRNAs. The lowest concentration of nucleic acids, detectable with our biosensor, has been found to be 1.1 \u00d7 10\u221217 M. The successful detection of target miRNAs, isolated from real plasma samples of PC patients, has also been demonstrated. We believe that the development of highly sensitive nanotechnology-based biosensors for the detection of PC markers is a step towards personalized medicine.<\/jats:p>","DOI":"10.3390\/s23177527","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:30:52Z","timestamp":1693391452000},"page":"7527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nanoribbon Biosensor-Based Detection of microRNA Markers of Prostate Cancer"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-1914","authenticated-orcid":false,"given":"Yuri D.","family":"Ivanov","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-1660","authenticated-orcid":false,"given":"Kristina A.","family":"Malsagova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4082-1247","authenticated-orcid":false,"given":"Kristina V.","family":"Goldaeva","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-9449","authenticated-orcid":false,"given":"Svetlana I.","family":"Kapustina","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-9095","authenticated-orcid":false,"given":"Tatyana O.","family":"Pleshakova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-1405","authenticated-orcid":false,"given":"Vladimir P.","family":"Popov","sequence":"additional","affiliation":[{"name":"Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia"}]},{"given":"Andrey F.","family":"Kozlov","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"given":"Rafael A.","family":"Galiullin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-7065","authenticated-orcid":false,"given":"Ivan D.","family":"Shumov","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia"}]},{"given":"Dmitry V.","family":"Enikeev","sequence":"additional","affiliation":[{"name":"Institute for Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia"}]},{"given":"Natalia V.","family":"Potoldykova","sequence":"additional","affiliation":[{"name":"Institute for Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia"}]},{"given":"Vadim S.","family":"Ziborov","sequence":"additional","affiliation":[{"name":"Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia"}]},{"given":"Oleg F.","family":"Petrov","sequence":"additional","affiliation":[{"name":"Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-7341","authenticated-orcid":false,"given":"Alexander Y.","family":"Dolgoborodov","sequence":"additional","affiliation":[{"name":"Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia"}]},{"given":"Alexander V.","family":"Glukhov","sequence":"additional","affiliation":[{"name":"JSC \u201cNovosibirsk Plant of Semiconductor Devices with OKB\u201d, 630082 Novosibirsk, Russia"}]},{"given":"Sergey V.","family":"Novikov","sequence":"additional","affiliation":[{"name":"Associate Printing-and-Publication Centre Technosphera, 125319 Moscow, Russia"}]},{"given":"Victoria K.","family":"Grabezhova","sequence":"additional","affiliation":[{"name":"JSC \u201cDesign Center for Biomicroelectronic Technologies \u201cVega\u201d\u201d, 630082 Novosibirsk, Russia"}]},{"given":"Evgeniy S.","family":"Yushkov","sequence":"additional","affiliation":[{"name":"Department for Business Project Management, National Research Nuclear University \u201cMEPhI\u201d, 115409 Moscow, Russia"}]},{"given":"Vladimir A.","family":"Konev","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0273-6700","authenticated-orcid":false,"given":"Oleg B.","family":"Kovalev","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia"}]},{"given":"Alexander 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