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Abnormal heart rate signals are an important indicator of cardiovascular disease. At present, the ECG signal acquisition instruments on the market are not portable and manual analysis is applied in data processing, which cannot address the above problems. To solve these problems, this study proposes an ECG acquisition and analysis system based on machine learning. The ECG analysis system responsible for ECG signal classification includes two parts: data preprocessing and machine learning models. Multiple types of models were built for overall classification, and model fusion was conducted. Firstly, traditional models such as logistic regression, support vector machines, and XGBoost were employed, along with feature engineering that primarily included morphological features and wavelet coefficient features. Subsequently, deep learning models, including convolutional neural networks and long short-term memory networks, were introduced and utilized for model fusion classification. The system\u2019s classification accuracy for ECG signals reached 99.13%. Future work will focus on optimizing the model and developing a more portable instrument that can be utilized in the field.<\/jats:p>","DOI":"10.3390\/s23177643","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:59:55Z","timestamp":1693796395000},"page":"7643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An ECG Signal Acquisition and Analysis System Based on Machine Learning with Model Fusion"],"prefix":"10.3390","volume":"23","author":[{"given":"Shi","family":"Su","sequence":"first","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"},{"name":"Innovative Research Laboratory of Nanjing Xi-Jing Advanced Materials Technology Ltd., Nanjing 211101, China"},{"name":"SEU-FEI Nano-Pico Center, Key Lab of MEMS of Ministry of Education, Collaborative Innovation, Center for Micro\/Nano Fabrication, Device and System, Southeast University, Nanjing 210096, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Zhu","sequence":"additional","affiliation":[{"name":"SEU-FEI Nano-Pico Center, Key Lab of MEMS of Ministry of Education, Collaborative Innovation, Center for Micro\/Nano Fabrication, Device and System, Southeast University, Nanjing 210096, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wan","sequence":"additional","affiliation":[{"name":"SEU-FEI Nano-Pico Center, Key Lab of MEMS of Ministry of Education, Collaborative Innovation, Center for Micro\/Nano Fabrication, Device and System, Southeast University, Nanjing 210096, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Laboratory of Novel Micro-Nano Devices and System Technology, School of Optoelectronics Engineering, Chongqing University, Chongqing 400044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangqing","family":"Sheng","sequence":"additional","affiliation":[{"name":"School of Economics and Management, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuihong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Aeronautical Engineering, Nanjing Vocational University of Industry Technology, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,3]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"China Cardiovascular Diseases Report 2018: An updated summary","volume":"17","author":"Ma","year":"2020","journal-title":"J. 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