{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:18:34Z","timestamp":1773260314812,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51672250"],"award-info":[{"award-number":["51672250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021C01180"],"award-info":[{"award-number":["2021C01180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019C04020"],"award-info":[{"award-number":["2019C04020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["18012134-Y"],"award-info":[{"award-number":["18012134-Y"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang International Science and Technology Cooperation Project","award":["51672250"],"award-info":[{"award-number":["51672250"]}]},{"name":"Zhejiang International Science and Technology Cooperation Project","award":["2021C01180"],"award-info":[{"award-number":["2021C01180"]}]},{"name":"Zhejiang International Science and Technology Cooperation Project","award":["2019C04020"],"award-info":[{"award-number":["2019C04020"]}]},{"name":"Zhejiang International Science and Technology Cooperation Project","award":["18012134-Y"],"award-info":[{"award-number":["18012134-Y"]}]},{"name":"Research Foundation of Zhejiang Sci-Tech University","award":["51672250"],"award-info":[{"award-number":["51672250"]}]},{"name":"Research Foundation of Zhejiang Sci-Tech University","award":["2021C01180"],"award-info":[{"award-number":["2021C01180"]}]},{"name":"Research Foundation of Zhejiang Sci-Tech University","award":["2019C04020"],"award-info":[{"award-number":["2019C04020"]}]},{"name":"Research Foundation of Zhejiang Sci-Tech University","award":["18012134-Y"],"award-info":[{"award-number":["18012134-Y"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The global burden of cancer is increasing rapidly, and nanomedicine offers promising prospects for enhancing the life expectancy of cancer patients. Janus nanoparticles (JNPs) have garnered considerable attention due to their asymmetric geometry, enabling multifunctionality in drug delivery and theranostics. However, achieving precise control over the self-assembly of JNPs in solution at the nanoscale level poses significant challenges. Herein, a low-temperature reversed-phase microemulsion system was used to obtain homogenous Mn3O4-Ag2S JNPs, which showed significant potential in cancer theranostics. Structural characterization revealed that the Ag2S (5\u201310 nm) part was uniformly deposited on a specific surface of Mn3O4 to form a Mn3O4-Ag2S Janus morphology. Compared to the single-component Mn3O4 and Ag2S particles, the fabricated Mn3O4-Ag2S JNPs exhibited satisfactory biocompatibility and therapeutic performance. Novel diagnostic and therapeutic nanoplatforms can be guided using the magnetic component in JNPs, which is revealed as an excellent T1 contrast enhancement agent in magnetic resonance imaging (MRI) with multiple functions, such as photo-induced regulation of the tumor microenvironment via producing reactive oxygen species and second near-infrared region (NIR-II) photothermal excitation for in vitro tumor-killing effects. The prime antibacterial and promising theranostics results demonstrate the extensive potential of the designed photo-responsive Mn3O4-Ag2S JNPs for biomedical applications.<\/jats:p>","DOI":"10.3390\/s23218930","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:28:13Z","timestamp":1698917293000},"page":"8930","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of Multifunctional Mn3O4-Ag2S Janus Nanoparticles for Enhanced T1-Magnetic Resonance Imaging and Photo-Induced Tumor Therapy"],"prefix":"10.3390","volume":"23","author":[{"given":"Yuguang","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Yuling","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Zhe","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Yike","family":"Hou","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Mingyue","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Shuqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Binghua","family":"Long","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Zhangsen","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing 312000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-7992","authenticated-orcid":false,"given":"Muhammad Zubair","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Xiangdong","family":"Kong","sequence":"additional","affiliation":[{"name":"Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. 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