{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:06:14Z","timestamp":1772604374160,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan National Science and Technology Council (NSTC)","award":["107-2311-B-038-001-MY2"],"award-info":[{"award-number":["107-2311-B-038-001-MY2"]}]},{"name":"Taiwan National Science and Technology Council (NSTC)","award":["111-2314-B-038-008"],"award-info":[{"award-number":["111-2314-B-038-008"]}]},{"name":"Taiwan National Science and Technology Council (NSTC)","award":["112-2314-B-038-063"],"award-info":[{"award-number":["112-2314-B-038-063"]}]},{"name":"Taiwan National Science and Technology Council (NSTC)","award":["DP2-TMU-112-N-10"],"award-info":[{"award-number":["DP2-TMU-112-N-10"]}]},{"name":"Higher Education Sprout Project","award":["107-2311-B-038-001-MY2"],"award-info":[{"award-number":["107-2311-B-038-001-MY2"]}]},{"name":"Higher Education Sprout Project","award":["111-2314-B-038-008"],"award-info":[{"award-number":["111-2314-B-038-008"]}]},{"name":"Higher Education Sprout Project","award":["112-2314-B-038-063"],"award-info":[{"award-number":["112-2314-B-038-063"]}]},{"name":"Higher Education Sprout Project","award":["DP2-TMU-112-N-10"],"award-info":[{"award-number":["DP2-TMU-112-N-10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Day\u2013night locomotor activities are the most readily observed outputs of the circadian (~24-h period) clock in many animals. Temporal patterns of the light\u2013dark schedule serve as input to the clock. While circadian activity patterns under various lighting conditions have been observed and documented, the full extent of circadian locomotor activities by genotype and entrainment remains uncharacterized. To facilitate large-scale, parallel cataloging of circadian input\u2013output patterns, we created the LocoBox, an easy-to-construct and easy-to-operate system that can control environmental light with flexible entrainment scenarios combined with the T-cycle and measure locomotor activities in individual home cages. The LocoBox is made using economical, common components, and normal breeding cages can be used for long-term recording. We provide details of the components and blueprints, along with software programs for Arduino and a Python-based graphical user interface (GUI), so that the system can be easily replicated in other laboratories.<\/jats:p>","DOI":"10.3390\/s23239469","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T07:41:32Z","timestamp":1701157292000},"page":"9469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["LocoBox: Modular Hardware and Open-Source Software for Circadian Entrainment and Behavioral Monitoring in Home Cages"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-498X","authenticated-orcid":false,"given":"Vuong Hung","family":"Truong","sequence":"first","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University, New Taipei City 235, Taiwan"},{"name":"Brain and Consciousness Research Centre (BCRC), TMU-Shuang Ho Hospital, New Taipei City 235, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2529-8013","authenticated-orcid":false,"given":"Jihwan","family":"Myung","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University, New Taipei City 235, Taiwan"},{"name":"Brain and Consciousness Research Centre (BCRC), TMU-Shuang Ho Hospital, New Taipei City 235, Taiwan"},{"name":"Graduate Institute of Medical Sciences (GIMS), Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.ph.55.030193.000313","article-title":"Temporal Organization: Reflections of a Darwinian Clock-Watcher","volume":"55","author":"Pittendrigh","year":"1993","journal-title":"Annu. 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