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To improve the flow rate of valveless piezoelectric pumps with flow tube structures and promote the miniaturization and integration of their designs, a cardioid flow tube valveless piezoelectric pump (CFTVPP) is proposed in this study. The symmetric dual-bend tube design of CFTVPP holds great potential in applications such as fluid mixing and heat dissipation systems. The structure and working principle of the CFTVPP are analyzed, and flow resistance and velocity equations are established. Furthermore, the flow characteristics of the cardioid flow tube (CFT) are investigated through computational fluid dynamics, and the output performance of valveless piezoelectric pumps with different bend radii is studied. Experimental results demonstrate that CFTVPP exhibits the pumping effect, with a maximum vibration amplitude of 182.5 \u03bcm (at 22 Hz, 100 V) and a maximum output flow rate of 5.69 mL\/min (at 25 Hz, 100 V). The results indicate that a smaller bend radius of the converging bend leads to a higher output flow rate, while the performance of valveless piezoelectric pumps with different diverging bends shows insignificant differences. The CFTVPP offers advantages such as a high output flow rate, low cost, small size for easy integration, and ease of manufacturing.<\/jats:p>","DOI":"10.3390\/s24010122","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T22:59:09Z","timestamp":1703545149000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design and Analysis of a Cardioid Flow Tube Valveless Piezoelectric Pump for Medical Applications"],"prefix":"10.3390","volume":"24","author":[{"given":"Jialong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-1681","authenticated-orcid":false,"given":"Zhenzhen","family":"Gui","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Yuxin","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Yaohua","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Tang","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Tian","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Bochuan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]},{"given":"Jianhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou 510006, China"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Peng, Y., Li, D., Yang, X., Ma, Z., and Mao, Z. (2023). A Review on Electrohydrodynamic (EHD) Pump. Micromachines, 14.","DOI":"10.20944\/preprints202301.0320.v1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11242-021-01614-1","article-title":"Investigate Effects of Microstructures on Nanoconfined Water Flow Behaviors from Viscous Dissipation Perspectives","volume":"140","author":"Wang","year":"2021","journal-title":"Transp. Porous Media"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1021\/acs.nanolett.8b02332","article-title":"A Direct Sensor to Measure Minute Liquid Flow Rates","volume":"18","author":"Sharma","year":"2018","journal-title":"Nano Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0925-4005(02)00348-9","article-title":"Generating High-Pressure Sub-Microliter Flow Rate in Packed Microchannel by Electroosmotic Force: Potential Application in Microfluidic Systems","volume":"88","author":"Chen","year":"2003","journal-title":"Sens. Actuators B"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mao, Z., Peng, Y., Hu, C., Ding, R., Yamada, Y., and Maeda, S. (2023). Soft Computing-Based Predictive Modeling of Flexible Electrohydrodynamic Pumps. Biomim. Intell. Rob., 3.","DOI":"10.1016\/j.birob.2023.100114"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106424","DOI":"10.1016\/j.ymssp.2019.106424","article-title":"A non-resonant sandwich type bidirectional stepping piezoelectric actuator driven by oblique two-dimensional trajectory: Design, analysis and experiment evaluation","volume":"135","author":"Wang","year":"2020","journal-title":"Mech. Syst. Signal Process."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106637","DOI":"10.1016\/j.ymssp.2020.106637","article-title":"Single-phase drive bending-bending piezoelectric actuator operated under 8-shaped trajectory vibration: Concept, computation and experiment evaluation","volume":"139","author":"Tian","year":"2020","journal-title":"Mech. Syst. Signal Process."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"106658","DOI":"10.1016\/j.ymssp.2020.106658","article-title":"Development of a novel spherical stator multi-DOF ultrasonic motor using in-plane non-axisymmetric mode","volume":"140","author":"Huang","year":"2020","journal-title":"Mech. Syst. Signal Proc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1109\/TIE.2018.2847655","article-title":"A Two-DOF Ultrasonic Motor Using a Longitudinal-Bending Hybrid Sandwich Transducer","volume":"66","author":"Liu","year":"2019","journal-title":"IEEE Trans. Ind. Electron."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1109\/TIE.2018.2873123","article-title":"Development of a Planar Piezoelectric Actuator Using Bending-Bending Hybrid Transducers","volume":"66","author":"Deng","year":"2019","journal-title":"IEEE Trans. Ind. Electron."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Shao, L., Pan, B., Hou, R., Jin, Y., and Yao, Y. (2022). User-friendly microfluidic manufacturing of hydrogel microspheres with sharp needle. Biofabrication, 14.","DOI":"10.1088\/1758-5090\/ac57a5"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113925","DOI":"10.1016\/j.sna.2022.113925","article-title":"On-demand preparation of calcium alginate microspheres via piezoelectric microfluidics","volume":"347","author":"Li","year":"2022","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_13","first-page":"1954","article-title":"Numerical optimization of three-cavity magneto mercury reciprocating (MMR) micropump","volume":"15","author":"Mehrabi","year":"2021","journal-title":"Eng. Appl. Comp. Fluid Mech."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Haldkar, R.K., Gupta, V.K., Sheorey, T., and Parinov, I.A. (2021). Design, modeling, and analysis of piezoelectric-actuated device for blood sampling. Appl. Sci., 11.","DOI":"10.3390\/app11188449"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bussmann, A., Leistner, H., Zhou, D., Wackerle, M., Congar, Y., Richter, M., and Hubbuch, J. (2021). Piezoelectric silicon micropump for drug delivery applications. Appl. Sci., 11.","DOI":"10.3390\/app11178008"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"111965","DOI":"10.1016\/j.sna.2020.111965","article-title":"Manipulate microfluid with an integrated butterfly valve for micropump application","volume":"306","author":"Tang","year":"2020","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102347","DOI":"10.1016\/j.mechatronics.2020.102347","article-title":"Performance analysis of valveless micropump with disposable chamber actuated through amplified piezo actuator (APA) for biomedical application","volume":"67","author":"Mohith","year":"2020","journal-title":"Mechatronics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"075030","DOI":"10.1088\/1361-665X\/ab8c23","article-title":"An indirect drug delivery device driven by piezoelectric pump","volume":"29","author":"Chen","year":"2020","journal-title":"Smart Mater. Struct."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ma, H., Hsu, Y., and Hsu, P. (2017). A Novel Hybrid Actuator Driven Magnetically in the Bi-Cell PEM Fuel Cell Stack. Metals, 7.","DOI":"10.3390\/met7110453"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.sna.2014.07.026","article-title":"High flow-rate piezoelectric micropump with two fixed ends polydimethylsiloxane valves and compressible spaces","volume":"218","author":"Wang","year":"2014","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.sna.2013.08.027","article-title":"A piezoelectric micropump with an integrated sensor based on space-division multiplexing","volume":"203","author":"Zhang","year":"2013","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s10832-012-9740-5","article-title":"A study on high-output piezoelectric micropumps for application in DMFC","volume":"30","author":"Park","year":"2013","journal-title":"J. Electroceram."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jpowsour.2013.03.161","article-title":"Development of a piezoelectric proton exchange membrane fuel cell stack (PZT-stack)","volume":"240","author":"Ma","year":"2013","journal-title":"J. Power Source"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.sna.2012.11.008","article-title":"Fabrication, assembly, and testing of a MEMS-enabled micro gas compressor for a 4:1 pressure ratio","volume":"190","author":"Lewis","year":"2013","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119612","DOI":"10.1016\/j.applthermaleng.2022.119612","article-title":"Comparative experimental study of heat sinks with piezoelectric pump","volume":"219","author":"Huang","year":"2023","journal-title":"Appl. Therm. Eng."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114566","DOI":"10.1016\/j.sna.2023.114566","article-title":"Performance study of external laval tube diffusion\/nozzle piezoelectric pump","volume":"361","author":"Hu","year":"2023","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Li, X., Liu, X., Dong, L., Sun, X., Tang, H., and Liu, G. (2022). A High-Performance Synthetic Jet Piezoelectric Air Pump with Petal-Shaped Channel. Sensors, 22.","DOI":"10.3390\/s22093227"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"113620","DOI":"10.1016\/j.sna.2022.113620","article-title":"A heat exchanger based on the piezoelectric pump for CPU cooling","volume":"342","author":"Huang","year":"2022","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"095023","DOI":"10.1088\/1361-665X\/ac182d","article-title":"A multi-chamber piezoelectric pump based on pumping unit with double circular piezoelectric unimorph actuators","volume":"30","author":"Wang","year":"2021","journal-title":"Smart Mater. Struct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"156030","DOI":"10.1016\/j.apsusc.2022.156030","article-title":"Origin of Superlubricity Promoted by Black Phosphorus Dotted with Gold Nanoparticles","volume":"613","author":"Tang","year":"2023","journal-title":"Appl. Surf. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"108921","DOI":"10.1016\/j.triboint.2023.108921","article-title":"Facile Fabrication of Aluminium Alloys with Gradient Nanostructures Incorporating \u03b1-Al2O3 Particles for Enhanced Tribological Properties","volume":"189","author":"Zheng","year":"2023","journal-title":"Tribol. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109426","DOI":"10.1016\/j.ress.2023.109426","article-title":"Fatigue Reliability Analysis and Assessment of Offshore Wind Turbine Blade Adhesive Bonding under the Coupling Effects of Multiple Environmental Stresses","volume":"238","author":"Li","year":"2023","journal-title":"Reliab. Eng. Syst. Saf."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jpowsour.2008.02.020","article-title":"Numerical study of a novel micro-diaphragm flow channel with piezoelectric device for proton exchange membrane fuel cells","volume":"180","author":"Ma","year":"2008","journal-title":"J. Power Source"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"You, R., Fu, X., and Duan, X. (2021, January 1\u20135). Acoustofluidic Based Wireless Micropump for Portable Drug Delivery Applications. Proceedings of the 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Mexico.","DOI":"10.1109\/EMBC46164.2021.9629811"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"123905","DOI":"10.1016\/j.ijheatmasstransfer.2023.123905","article-title":"A compact jet array impingement cooling system driven by integrated piezoelectric micropump","volume":"205","author":"Fan","year":"2023","journal-title":"Int. J. Heat Mass Transf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10404-009-0533-3","article-title":"Valveless micropump with acoustically featured pumping chamber","volume":"8","author":"Wang","year":"2010","journal-title":"Microfluid. Nanofluid."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.sna.2013.09.033","article-title":"Bidirectional flow micropump based on dynamic rectification","volume":"204","author":"Chee","year":"2013","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113871","DOI":"10.1016\/j.sna.2022.113871","article-title":"Controllable synthesis of silver nanoparticles using a multi-stage microfluidic reactor driven by two valveless piezoelectric pumps","volume":"346","author":"Yang","year":"2022","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.sna.2008.01.016","article-title":"Development of serial-connection piezoelectric pumps","volume":"144","author":"Kan","year":"2008","journal-title":"Sens. Actuators A-Phys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10652-018-9637-1","article-title":"A Comparison of Standard k\u2013\u03b5 and Realizable k\u2013\u03b5 Turbulence Models in Curved and Confluent Channels","volume":"19","author":"Shaheed","year":"2019","journal-title":"Environ. Fluid Mech."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/1\/122\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:57Z","timestamp":1760132517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/1\/122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,25]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["s24010122"],"URL":"https:\/\/doi.org\/10.3390\/s24010122","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,25]]}}}