{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:35:37Z","timestamp":1775018137995,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:00:00Z","timestamp":1705104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R03NS114335"],"award-info":[{"award-number":["R03NS114335"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["ALLRP-576386-22"],"award-info":[{"award-number":["ALLRP-576386-22"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["ALLRP-578524-22"],"award-info":[{"award-number":["ALLRP-578524-22"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["ALLRP 586244-23"],"award-info":[{"award-number":["ALLRP 586244-23"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Endowed Manitoba Public Insurance (MPI) Chair in Neuroscience and the Natural Sciences and Engineering Research Council of Canada","award":["R03NS114335"],"award-info":[{"award-number":["R03NS114335"]}]},{"name":"Endowed Manitoba Public Insurance (MPI) Chair in Neuroscience and the Natural Sciences and Engineering Research Council of Canada","award":["ALLRP-576386-22"],"award-info":[{"award-number":["ALLRP-576386-22"]}]},{"name":"Endowed Manitoba Public Insurance (MPI) Chair in Neuroscience and the Natural Sciences and Engineering Research Council of Canada","award":["ALLRP-578524-22"],"award-info":[{"award-number":["ALLRP-578524-22"]}]},{"name":"Endowed Manitoba Public Insurance (MPI) Chair in Neuroscience and the Natural Sciences and Engineering Research Council of Canada","award":["ALLRP 586244-23"],"award-info":[{"award-number":["ALLRP 586244-23"]}]},{"name":"National Institutes of Health (NIH)","award":["R03NS114335"],"award-info":[{"award-number":["R03NS114335"]}]},{"name":"National Institutes of Health (NIH)","award":["ALLRP-576386-22"],"award-info":[{"award-number":["ALLRP-576386-22"]}]},{"name":"National Institutes of Health (NIH)","award":["ALLRP-578524-22"],"award-info":[{"award-number":["ALLRP-578524-22"]}]},{"name":"National Institutes of Health (NIH)","award":["ALLRP 586244-23"],"award-info":[{"award-number":["ALLRP 586244-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The contemporary monitoring of cerebrovascular reactivity (CVR) relies on invasive intracranial pressure (ICP) monitoring which limits its application. Interest is shifting towards near-infrared spectroscopic regional cerebral oxygen saturation (rSO2)-based indices of CVR which are less invasive and have improved spatial resolution. This study aims to examine and model the relationship between ICP and rSO2-based indices of CVR. Through a retrospective cohort study of prospectively collected physiologic data in moderate to severe traumatic brain injury (TBI) patients, linear mixed effects modeling techniques, augmented with time-series analysis, were utilized to evaluate the ability of rSO2-based indices of CVR to model ICP-based indices. It was found that rSO2-based indices of CVR had a statistically significant linear relationship with ICP-based indices, even when the hierarchical and autocorrelative nature of the data was accounted for. This strengthens the body of literature indicating the validity of rSO2-based indices of CVR and potential greatly expands the scope of CVR monitoring.<\/jats:p>","DOI":"10.3390\/s24020499","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T07:25:07Z","timestamp":1705303507000},"page":"499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Non-Invasive Estimation of Intracranial Pressure-Derived Cerebrovascular Reactivity Using Near-Infrared Spectroscopy Sensor Technology in Acute Neural Injury: A Time-Series Analysis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-2065","authenticated-orcid":false,"given":"Alwyn","family":"Gomez","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W2, Canada"},{"name":"Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-0189","authenticated-orcid":false,"given":"Logan","family":"Froese","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias J. 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