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There is increasing evidence that highly toxic amyloid-\u03b2 oligomers (A\u03b2Os) lead to tau protein aggregation, hyperphosphorylation, neuroinflammation, neuronal loss, synaptic loss, and dysfunction. Although the effects of A\u03b2Os on neurons have been investigated using conventional biochemical experiments, there are no established criteria for electrical evaluation. To this end, we explored electrophysiological changes in mouse hippocampal neurons (HT22) following exposure to A\u03b2Os and\/or naringenin (Nar, a flavonoid compound) using electrical impedance spectroscopy (EIS). A\u03b2O-induced HT22 showed a decreased impedance amplitude and increased phase angle, and the addition of Nar reversed these changes. The characteristic frequency was markedly increased with A\u03b2O exposure, which was also reversed by Nar. The A\u03b2Os decreased intranuclear and cytoplasmic resistance and increased nucleus resistance and extracellular capacitance. Overall, the innovative construction of the eight-element CPE-equivalent circuit model further reflects that the pseudo-capacitance of the cell membrane and cell nucleus was increased in the A\u03b2O-induced group. This study conclusively revealed that A\u03b2Os induce cytotoxic effects by disrupting the resistance characteristics of unit membranes. The results further support that EIS is an effective technique for evaluating A\u03b2O-induced neuronal damage and microscopic electrical distinctions in the sub-microscopic structure of reactive cells.<\/jats:p>","DOI":"10.3390\/s24041211","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T06:59:26Z","timestamp":1707893966000},"page":"1211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Amyloid-\u03b2 Oligomer-Induced Electrophysiological Mechanisms and Electrical Impedance Changes in Neurons"],"prefix":"10.3390","volume":"24","author":[{"given":"Shimeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyu","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-3255","authenticated-orcid":false,"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1038\/s41598-018-22979-2","article-title":"An acute functional screen identifies an effective antibody targeting amyloid-\u03b2 oligomers based on calcium imaging","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. 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