{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:23:48Z","timestamp":1780975428430,"version":"3.54.1"},"reference-count":76,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONAHCYT","award":["A1-S-8817"],"award-info":[{"award-number":["A1-S-8817"]}]},{"name":"CONAHCYT","award":["1564464"],"award-info":[{"award-number":["1564464"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The goal of the sensor industry is to develop innovative, energy-efficient, and reliable devices to detect molecules relevant to economically important sectors such as clinical diagnoses, environmental monitoring, food safety, and wearables. The current demand for portable, fast, sensitive, and high-throughput platforms to detect a plethora of new analytes is continuously increasing. The 2D transition metal dichalcogenides (2D-TMDs) are excellent candidates to fully meet the stringent demands in the sensor industry; 2D-TMDs properties, such as atomic thickness, large surface area, and tailored electrical conductivity, match those descriptions of active sensor materials. However, the detection capability of 2D-TMDs is limited by their intrinsic tendency to aggregate and settle, which reduces the surface area available for detection, in addition to the weak interactions that pristine 2D-TMDs normally exhibit with analytes. Chemical functionalization has been proposed as a consensus solution to these limitations. Tailored surface modification of 2D-TMDs, either by covalent functionalization, non-covalent functionalization, or a mixture of both, allows for improved specificity of the surface\u2013analyte interaction while reducing van der Waals forces between 2D-TMDs avoiding agglomeration and precipitation. From this perspective, we review the recent advances in improving the detection of biomolecules, heavy metals, and gases using chemically functionalized 2D-TMDs. Covalent and non-covalent functionalized 2D-TMDs are commonly used for the detection of biomolecules and metals, while 2D-TMDs functionalized with metal nanoparticles are used for gas and Raman sensors. Finally, we describe the limitations and further strategies that might pave the way for miniaturized, flexible, smart, and low-cost sensing devices.<\/jats:p>","DOI":"10.3390\/s24061817","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T12:14:40Z","timestamp":1710245680000},"page":"1817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chemically Functionalized 2D Transition Metal Dichalcogenides for Sensors"],"prefix":"10.3390","volume":"24","author":[{"given":"Selene","family":"Acosta","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud y Biomedicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Sierra Leona 550, Lomas de San Luis, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mildred","family":"Quintana","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud y Biomedicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Sierra Leona 550, Lomas de San Luis, San Luis Potos\u00ed 78210, Mexico"},{"name":"Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Parque Chapultepec 1570, Privadas del Pedregal, San Luis Potos\u00ed 78295, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116785","DOI":"10.1016\/j.trac.2022.116785","article-title":"Microarray-Based Chemical Sensors and Biosensors: Fundamentals and Food Safety Applications","volume":"158","author":"Chen","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.snb.2018.03.074","article-title":"Wireless Chemical Sensors and Biosensors: A Review","volume":"266","author":"Kassal","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1021\/cr068102g","article-title":"Optical Chemical Sensors","volume":"108","author":"McDonagh","year":"2008","journal-title":"Chem. 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