{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:14:24Z","timestamp":1760109264900,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This paper presents an enhanced version of our previously developed bio-optical transceiver, presenting a significant advancement in nanosensor technology. Using self-assembled polymers, this nanodevice is capable of electron detection while maintaining biocompatibility, an essential feature for in vivo medical biosensors. This enhancement finds significance in the field of infectious disease control, particularly in the early detection of respiratory viruses, including high-threat pathogens such as SARS-CoV-2. The proposed system harnesses bioluminescence by converting electric signaling to visible blue light, effectively opening the path of linking nano-sized mechanisms to larger-scale systems, thereby pushing the boundaries of in vivo biomedical sensing. The performance evaluation of our technology is analytical and is based on the use of Markov chains, through which we assess the bit error probability. The calculated improvements indicate that this technology qualifies as a forerunner in terms of supporting the communication needs of smaller, safer, and more efficient manufactured sensor technologies for in vivo medical applications.<\/jats:p>","DOI":"10.3390\/s24082584","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T06:21:12Z","timestamp":1713421272000},"page":"2584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design of Bio-Optical Transceiver for In Vivo Biomedical Sensor Applications"],"prefix":"10.3390","volume":"24","author":[{"given":"Dimitrios","family":"Makrakis","sequence":"first","affiliation":[{"name":"School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-3742","authenticated-orcid":false,"given":"Oussama Abderrahmane","family":"Dambri","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhakim Senhaji","family":"Hafid","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Operations Research, University of Montreal, Montreal, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1109\/MWC.2010.5675779","article-title":"The Internet of nano-things","volume":"17","author":"Akyildiz","year":"2010","journal-title":"IEEE Wirel. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1109\/MCOM.2015.7060516","article-title":"The internet of bio-nano things","volume":"53","author":"Akyildiz","year":"2015","journal-title":"IEEE Commun. Mag."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1109\/JSAC.2010.100509","article-title":"A physical end-to-end model for molecular communication in nanonetworks","volume":"28","author":"Pierobon","year":"2010","journal-title":"IEEE J. Sel. Areas Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1109\/TMBMC.2015.2501745","article-title":"ISI Mitigation Techniques in Molecular Communication","volume":"1","author":"Tepekule","year":"2015","journal-title":"IEEE Trans. Mol. Biol. Multi-Scale Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1109\/TNB.2012.2190546","article-title":"Molecular Communication Using Brownian Motion with Drift","volume":"11","author":"Kadloor","year":"2012","journal-title":"IEEE Trans. NanoBiosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1109\/TNB.2016.2557350","article-title":"Ion Channel Based Bio-Synthetic Modulator for Diffusive Molecular Communication","volume":"15","author":"Arjmandi","year":"2016","journal-title":"IEEE Trans. Nanobiosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1109\/TNB.2014.2368593","article-title":"A comprehensive analysis of strength-based optimum signal detection in concentration-encoded molecular communication with spike transmission","volume":"14","author":"Mahfuz","year":"2015","journal-title":"IEEE Trans. Nanobiosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1109\/TNB.2017.2786229","article-title":"Adaptive Detection and ISI Mitigation for Mobile Molecular Communication","volume":"17","author":"Chang","year":"2018","journal-title":"IEEE Trans. Nanobiosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1109\/TNB.2013.2295546","article-title":"Improving Receiver Performance of Diffusive Molecular Communication with Enzymes","volume":"13","author":"Noel","year":"2014","journal-title":"IEEE Trans. NanoBiosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nancom.2017.05.001","article-title":"Influence of neighboring absorbing receivers upon the inter-symbol interference in a diffusion-based molecular communication system","volume":"14","author":"Assaf","year":"2017","journal-title":"Nano Commun. Netw."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1109\/JSAC.2016.2525538","article-title":"Molecular MIMO: From Theory to Prototype","volume":"34","author":"Koo","year":"2016","journal-title":"IEEE J. Sel. Areas Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1109\/TMBMC.2021.3118943","article-title":"Modeling self-assembly of polymer-based wired nano-communication channel","volume":"8","author":"Dambri","year":"2022","journal-title":"IEEE Trans. Mol. Biol. Multi-Scale Commun."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Dambri, O.A., and Cherkaoui, S. (2020, January 7\u201311). Toward a wired ad hoc nanonetwork. Proceedings of the ICC 2020\u2014IEEE International Conference on Communications ICC, Dublin, Ireland.","DOI":"10.1109\/ICC40277.2020.9148728"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100406","DOI":"10.1016\/j.nancom.2022.100406","article-title":"Intrabody hybrid perpetual nanonetworks based on simultaneous wired and wireless nanocommunications","volume":"32\u201333","author":"Asghari","year":"2022","journal-title":"Nano Commun. Netw."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1109\/JSAC.2014.2367666","article-title":"A stochastic model for electron transfer in bacterial cables","volume":"32","author":"Michelusi","year":"2014","journal-title":"IEEE J. Sel. Areas Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1109\/TNB.2022.3182587","article-title":"Design and evaluation of a receiver for wired nano-communication networks","volume":"22","author":"Dambri","year":"2023","journal-title":"IEEE Trans. NanoBiosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1089\/ars.2012.5104","article-title":"Mitochondrial energy and redox signaling in plants","volume":"18","author":"Finkemeier","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1504\/IJEX.2010.031988","article-title":"Exergy analyses of the biochemical processes of photosynthesis","volume":"7","author":"Lems","year":"2010","journal-title":"Int. J. Exergy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-1-4831-9969-6.50010-X","article-title":"The chemistry of bioluminescence","volume":"Volume 1","author":"Sanadi","year":"1966","journal-title":"Series Current Topics in Bioenergetics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/0471143030.cb0327s68","article-title":"Isolation of endoplasmic reticulum, mitochondria, and mitochondria-associated membrane and detergent resistant membrane fractions from transfected cells and from human cytomegalovirus- infected primary fibroblasts","volume":"68","author":"Williamson","year":"2015","journal-title":"Curr. Protoc. Cell Biol."},{"key":"ref_21","first-page":"1009","article-title":"Homogenization of mammalian cells","volume":"2015","author":"Lamberti","year":"2015","journal-title":"Cold Spring Harb. Protoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1574-6968.1982.tb00241.x","article-title":"Isolation and characterisation of rough and smooth endoplasmic reticulum from Saccharomyces cerevisiae","volume":"15","author":"Swida","year":"1982","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_23","unstructured":"Goldman, C.A. (1992). Tested Studies for Laboratory Teaching, Proceedings of the 13th Workshop of the Association for Biology Laboratory Education (ABLE), Laramie, Wyoming, 11\u201315 June 1991, ERIC."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1021\/ma501897j","article-title":"Microencapsulation of active ingredients using PDMS as shell material","volume":"47","author":"Teixeira","year":"2014","journal-title":"Macromolecules"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1039\/b315999j","article-title":"Hollow permeable polysiloxane capsules: A novel approach for fabrication, guest encapsulation and morphology studies","volume":"14","author":"Wang","year":"2004","journal-title":"J. Mater. Chem."},{"key":"ref_26","unstructured":"Katz, A.M. (2010). Physiology of the Heart, Lippincott Williams and Wilkins. [5th ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"G672","DOI":"10.1152\/ajpgi.00149.2009","article-title":"Effects of electrical stimulation on isolated rodent gastric smooth muscle cells evaluated via a joint computational simulation and experimental approach","volume":"297","author":"Du","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_28","unstructured":"Wild, D. (2013). The Immunoassay Handbook, Elsevier. [4th ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/bi00838a015","article-title":"Properties of the bioluminescent protein Aequorin","volume":"8","author":"Shimomura","year":"1969","journal-title":"Biochemistry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/abio.1994.1394","article-title":"Changes in free calcium in the endoplasmic reticulum of living cells detected using targeted aequorin","volume":"221","author":"Kendall","year":"1994","journal-title":"Anal. Biochem."},{"key":"ref_31","unstructured":"Sadr, R., and Hurd, W.J. (1987). The Telecommunications and Data Acquisition Report, Available online: https:\/\/ui.adsabs.harvard.edu\/abs\/1987tdar.nasa..158S."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/8\/2584\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:29:56Z","timestamp":1760106596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/8\/2584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["s24082584"],"URL":"https:\/\/doi.org\/10.3390\/s24082584","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}