{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:14:47Z","timestamp":1773072887775,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Off-clamp partial nephrectomy represents one of the latest developments in nephron-sparing surgery, with the goal of preserving renal function and reducing ischemia time. The aim of this study was to evaluate and compare the functional, oncologic, and perioperative outcomes between off-clamp robot-assisted partial nephrectomy (off-C RAPN) and off-clamp open partial nephrectomy (off-C OPN) through a propensity score-matched (PSM) analysis. A 1:1 PSM analysis was used to balance variables potentially affecting postoperative outcomes. To report surgical quality, 1 year trifecta was used. Univariable Cox regression analysis was performed to identify predictors of trifecta achievement. The Kaplan\u2013Meier method was used to compare cancer-specific survival (CSS), overall survival (OS), disease-free survival (DFS), and metastasis-free survival (MFS) probabilities between groups. Overall, 542 patients were included. After PSM analysis, two homogeneous cohorts of 147 patients were obtained. The off-C RAPN cohort experienced shorter length of stay (LoS) (3.4 days vs. 5.4 days; p &lt; 0.001), increased likelihoods of achieving 1 year trifecta (89.8% vs. 80.3%; p = 0.03), lower postoperative Clavien\u2013Dindo \u2264 2 complications (1.3% vs. 18.3%, p &lt; 0.001), and lower postoperative transfusion rates (3.4% vs. 12.2%, p = 0.008). At univariable analysis, the surgical approach (off-C RAPN vs. off-C OPN, OR 2.22, 95% CI 1.09\u20134.46, p = 0.02) was the only predictor of 1 year trifecta achievement. At Kaplan\u2013Meier analysis, no differences were observed between the two groups in terms of OS (log-rank p = 0.451), CSS (log-rank p = 0.476), DFS (log-rank p = 0.678), and MFS (log-rank p = 0.226). Comparing RAPN and OPN in a purely off-clamp scenario, the minimally invasive approach proved to be a feasible and safe surgical approach, with a significantly lower LoS and minor rate of postoperative complications and transfusions as a result of improved surgical quality expressed by higher 1 year trifecta achievement.<\/jats:p>","DOI":"10.3390\/s24092822","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T08:49:24Z","timestamp":1714380564000},"page":"2822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Perioperative, Functional, and Oncologic Outcomes of Open vs. Robot-Assisted Off-Clamp Partial Nephrectomy: A Propensity Scored Match Analysis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-2209","authenticated-orcid":false,"given":"Riccardo","family":"Mastroianni","sequence":"first","affiliation":[{"name":"Urology, 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4480-9090","authenticated-orcid":false,"given":"Gabriele","family":"Tuderti","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Brassetti","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Anceschi","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariaconsiglia","family":"Ferriero","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Misuraca","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"D\u2019Annunzio","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5139-9993","authenticated-orcid":false,"given":"Alfredo Maria","family":"Bove","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Guaglianone","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, 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Azienda Ospedaliero-Universitaria delle Marche, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Leonardo","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8313-5338","authenticated-orcid":false,"given":"Andrea Benedetto","family":"Galosi","sequence":"additional","affiliation":[{"name":"Urology Division, Azienda Ospedaliero-Universitaria delle Marche, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-9025","authenticated-orcid":false,"given":"Giuseppe","family":"Simone","sequence":"additional","affiliation":[{"name":"Urology, IRCCS \u201cRegina Elena\u201d National Cancer Institute, 00128 Rome, 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