{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T13:17:54Z","timestamp":1776518274325,"version":"3.51.2"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2022YFF1202303"],"award-info":[{"award-number":["2022YFF1202303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["62071447"],"award-info":[{"award-number":["62071447"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022YFF1202303"],"award-info":[{"award-number":["2022YFF1202303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62071447"],"award-info":[{"award-number":["62071447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In recent years, there has been a considerable amount of research on visual evoked potential (VEP)-based brain\u2013computer interfaces (BCIs). However, it remains a big challenge to detect VEPs elicited by small visual stimuli. To address this challenge, this study employed a 256-electrode high-density electroencephalogram (EEG) cap with 66 electrodes in the parietal and occipital lobes to record EEG signals. An online BCI system based on code-modulated VEP (C-VEP) was designed and implemented with thirty targets modulated by a time-shifted binary pseudo-random sequence. A task-discriminant component analysis (TDCA) algorithm was employed for feature extraction and classification. The offline and online experiments were designed to assess EEG responses and classification performance for comparison across four different stimulus sizes at visual angles of 0.5\u00b0, 1\u00b0, 2\u00b0, and 3\u00b0. By optimizing the data length for each subject in the online experiment, information transfer rates (ITRs) of 126.48 \u00b1 14.14 bits\/min, 221.73 \u00b1 15.69 bits\/min, 258.39 \u00b1 9.28 bits\/min, and 266.40 \u00b1 6.52 bits\/min were achieved for 0.5\u00b0, 1\u00b0, 2\u00b0, and 3\u00b0, respectively. This study further compared the EEG features and classification performance of the 66-electrode layout from the 256-electrode EEG cap, the 32-electrode layout from the 128-electrode EEG cap, and the 21-electrode layout from the 64-electrode EEG cap, elucidating the pivotal importance of a higher electrode density in enhancing the performance of C-VEP BCI systems using small stimuli.<\/jats:p>","DOI":"10.3390\/s24113521","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T06:08:14Z","timestamp":1717049294000},"page":"3521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High-Density Electroencephalogram Facilitates the Detection of Small Stimuli in Code-Modulated Visual Evoked Potential Brain\u2013Computer Interfaces"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-7852","authenticated-orcid":false,"given":"Qingyu","family":"Sun","sequence":"first","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China"},{"name":"School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Shaojie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China"}]},{"given":"Guoya","family":"Dong","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-0199","authenticated-orcid":false,"given":"Weihua","family":"Pei","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China"},{"name":"School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Xiaorong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Yijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China"},{"name":"School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Chinese Institute for Brain Research, Beijing 102206, China"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1388-2457(02)00057-3","article-title":"Brain-computer interfaces for communication and control","volume":"113","author":"Wolpaw","year":"2002","journal-title":"Clin. 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