{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:08:08Z","timestamp":1760144888887,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Friuli Venezia Giulia POR FESR 2014\u20132020, Activity 1.3.b-DGR","award":["8981\/LAVFORU"],"award-info":[{"award-number":["8981\/LAVFORU"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Multiple myeloma (MM) patients complain of pain and stiffness limiting motility. To determine if patients can benefit from vertebroplasty, we assessed muscle activation and co-activation before and after surgery. Five patients with MM and five healthy controls performed sitting-to-standing and lifting tasks. Patients performed the task before and one month after surgery. Surface electromyography (sEMG) was recorded bilaterally over the erector spinae longissimus and rectus abdominis superior muscles to evaluate the trunk muscle activation and co-activation and their mean, maximum, and full width at half maximum were evaluated. Statistical analyses were performed to compare MM patients before and after the surgery, MM and healthy controls and to investigate any correlations between the muscle\u2019s parameters and the severity of pain in patients. The results reveal increased activations and co-activations after vertebroplasty as well as in comparison with healthy controls suggesting how MM patients try to control the trunk before and after vertebroplasty surgery. The findings confirm the beneficial effects of vertebral consolidation on the pain experienced by the patient, despite an overall increase in trunk muscle activation and co-activation. Therefore, it is important to provide patients with rehabilitation treatment early after surgery to facilitate the CNS to correctly stabilize the spine without overloading it with excessive co-activations.<\/jats:p>","DOI":"10.3390\/s24113527","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T06:08:14Z","timestamp":1717049294000},"page":"3527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Instrumental Evaluation of the Effects of Vertebral Consolidation Surgery on Trunk Muscle Activations and Co-Activations in Patients with Multiple Myeloma: Preliminary Results"],"prefix":"10.3390","volume":"24","author":[{"given":"Barbara","family":"Montante","sequence":"first","affiliation":[{"name":"Unit of Onco-Hematology and Stem Cell Transplantation and Cellular Therapies, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]},{"given":"Benedetta","family":"Zampa","sequence":"additional","affiliation":[{"name":"Unit of Onco-Hematology and Stem Cell Transplantation and Cellular Therapies, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]},{"given":"Luca","family":"Balestreri","sequence":"additional","affiliation":[{"name":"Radiology Department, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]},{"given":"Rosanna","family":"Ciancia","sequence":"additional","affiliation":[{"name":"Unit of Onco-Hematology and Stem Cell Transplantation and Cellular Therapies, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-0025","authenticated-orcid":false,"given":"Giorgia","family":"Chini","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Istituto Nazionale per l\u2019Assicurazione Contro gli Infortuni sul Lavoro, 00078 Monte Porzio Catone, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-6166","authenticated-orcid":false,"given":"Alberto","family":"Ranavolo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Istituto Nazionale per l\u2019Assicurazione Contro gli Infortuni sul Lavoro, 00078 Monte Porzio Catone, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7932-2827","authenticated-orcid":false,"given":"Maurizio","family":"Rupolo","sequence":"additional","affiliation":[{"name":"Unit of Onco-Hematology and Stem Cell Transplantation and Cellular Therapies, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-5415","authenticated-orcid":false,"given":"Zimi","family":"Sawacha","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padua, 35131 Padua, Italy"}]},{"given":"Martina","family":"Urbani","sequence":"additional","affiliation":[{"name":"Radiology Department, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]},{"given":"Tiwana","family":"Varrecchia","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Istituto Nazionale per l\u2019Assicurazione Contro gli Infortuni sul Lavoro, 00078 Monte Porzio Catone, Italy"}]},{"given":"Mariagrazia","family":"Michieli","sequence":"additional","affiliation":[{"name":"Unit of Onco-Hematology and Stem Cell Transplantation and Cellular Therapies, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103205","DOI":"10.1016\/j.critrevonc.2020.103205","article-title":"Management of acute spinal cord compression in multiple myeloma","volume":"160","author":"Chen","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4103\/IJPC.IJPC_233_19","article-title":"Chemotherapy-Induced Peripheral Neuropathy and its Impact on Health-Related Quality of Life among Multiple Myeloma Patients: A Single-Center Experience","volume":"26","author":"Shaheen","year":"2020","journal-title":"Indian J. Palliat. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1158\/1078-0432.CCR-21-1059","article-title":"Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration","volume":"27","author":"Anderson","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104546","DOI":"10.1155\/2013\/104546","article-title":"Diagnosis and treatment of bone disease in multiple myeloma: Spotlight on spinal involvement","volume":"2013","author":"Tosi","year":"2013","journal-title":"Scientifica"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Larsen, R.F., Jarden, M., Minet, L.R., Fr\u00f8lund, U.C., M\u00f6ller, S., and Abildgaard, N. (2020). Physical function in patients newly diagnosed with multiple myeloma; a Danish cohort study. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-6637-6"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jama.2022.0003","article-title":"Diagnosis and Management of Multiple Myeloma: A Review","volume":"327","author":"Cowan","year":"2022","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e045854","DOI":"10.1136\/bmjopen-2020-045854","article-title":"Vertebroplasty in patients with multiple myeloma with vertebral compression fractures: Protocol for a single-blind randomised controlled trial","volume":"11","author":"Wickstroem","year":"2021","journal-title":"BMJ Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3174\/ajnr.A0918","article-title":"Vertebroplasty in multiple myeloma: Outcomes in a large patient series","volume":"29","author":"McDonald","year":"2008","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00402-012-1474-y","article-title":"Percutaneous vertebroplasty for pathological vertebral compression fractures secondary to multiple myeloma","volume":"132","author":"Chen","year":"2012","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00270-011-0111-4","article-title":"Percutaneous vertebroplasty in multiple myeloma: Prospective long-term follow-up in 106 consecutive patients","volume":"35","author":"Anselmetti","year":"2012","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/BSD.0b013e3181454630","article-title":"Percutaneous vertebroplasty in multiple myeloma vertebral involvement","volume":"21","author":"Masala","year":"2008","journal-title":"J. Spinal Disord. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jelekin.2005.06.006","article-title":"Active trunk stiffness increases with co-contraction","volume":"16","author":"Lee","year":"2006","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1152\/jn.00084.2018","article-title":"Muscle coactivation: Definitions, mechanisms, and functions","volume":"120","author":"Latash","year":"2018","journal-title":"J. Neurophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103297","DOI":"10.1016\/j.ergon.2022.103297","article-title":"Trunk muscle co-activation and activity in one-and two-person lifting","volume":"89","author":"Chini","year":"2022","journal-title":"Int. J. Ind. Ergon."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1097\/00007632-200006010-00012","article-title":"Cost-Benefit of Muscle Cocontraction in Protecting Against Spinal Instability","volume":"25","author":"Granata","year":"2000","journal-title":"Spine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jor.1100110606","article-title":"Electromyographic studies of the lumbar trunk musculature during the generation of low-level trunk acceleration","volume":"11","author":"Marras","year":"1993","journal-title":"J. Orthop. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Varrecchia, T., Conforto, S., De Nunzio, A.M., Draicchio, F., Falla, D., and Ranavolo, A. (2022). Trunk muscle coactivation in people with and without low back pain during fatiguing frequency-dependent lifting activities. Sensors, 22.","DOI":"10.3390\/s22041417"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1050-6411(97)84626-3","article-title":"Cocontraction in three age groups of children during treadmill locomotion","volume":"7","author":"Frost","year":"1997","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.jbiomech.2011.02.077","article-title":"The utility of an empirically derived co-activation ratio for muscle force prediction through optimization","volume":"17","author":"Brookham","year":"2011","journal-title":"J. Biomech."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.joca.2004.05.005","article-title":"Control of frontal plane knee laxity during gait in patients with medial compartment knee osteoarthritis","volume":"12","author":"Lewek","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.clinbiomech.2003.08.007","article-title":"Alterations in lower extremity movement and muscle activation patterns in individuals with knee osteoarthritis","volume":"19","author":"Childs","year":"2004","journal-title":"Clin. Biomech."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00003677-200510000-00008","article-title":"The role of mechanical loading in the onset and progression of osteoarthritis","volume":"33","author":"Griffin","year":"2005","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.clinbiomech.2011.04.011","article-title":"The impact of stochastic resonance electrical stimulation and knee sleeve on impulsive loading and muscle co-contraction during gait in knee osteoarthritis","volume":"26","author":"Collins","year":"2011","journal-title":"Clin. Biomech."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"572069","DOI":"10.3389\/fneur.2020.572069","article-title":"Critical issues and imminent challenges in the use of sEMG in return-to-work rehabilitation of patients affected by neurological disorders in the epoch of Human\u2013Robot collaborative technologies","volume":"11","author":"Ranavolo","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3389\/fneur.2020.00934","article-title":"Surface EMG in Clinical Assessment and Neurorehabilitation: Barriers Limiting Its Use","volume":"11","author":"Campanini","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"560363","DOI":"10.3389\/fneur.2020.560363","article-title":"Critical Appraisal of Surface Electromyography (sEMG) as a Taught Subject and Clinical Tool in Medicine and Kinesiology","volume":"11","author":"Medved","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Al-Ayyad, M., Owida, H.A., De Fazio, R., Al-Naami, B., and Visconti, P. (2023). Electromyography Monitoring Systems in Rehabilitation: A Review of Clinical Applications, Wearable Devices and Signal Acquisition Methodologies. Electronics, 12.","DOI":"10.3390\/electronics12071520"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7001350010p1","DOI":"10.5014\/ajot.2016.015487","article-title":"Range of Motion Requirements for Upper-Limb Activities of Daily Living","volume":"70","author":"Gates","year":"2016","journal-title":"Am. J. Occup. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1589\/jpts.27.939","article-title":"Daily sit-to-stands performed by adults: A systematic review","volume":"27","author":"Bohannon","year":"2015","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_30","first-page":"129","article-title":"Pain assessment: Global use of the Brief Pain Inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0167-9457(91)90046-Z","article-title":"A gait analysis data collection and reduction technique","volume":"10","author":"Davis","year":"1991","journal-title":"Hum. Mov. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1050-6411(00)00027-4","article-title":"Development of recommendations for SEMG sensors and sensor placement procedures","volume":"10","author":"Hermens","year":"2000","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Barbero, M., Merletti, R., and Rainoldi, A. (2012). Atlas of Muscle Innervation Zones: Understanding Surface Electromyography and Its Applications, Springer Science & Business Media.","DOI":"10.1007\/978-88-470-2463-2"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1016\/j.jelekin.2007.10.004","article-title":"The interpretation of abdominal wall muscle recruitment strategies change when the electrocardiogram (ECG) is removed from the electromyogram (EMG)","volume":"19","author":"Butler","year":"2009","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jelekin.2005.07.003","article-title":"Elimination of electrocardiogram contamination from electromyogram signals: An evaluation of currently used removal techniques","volume":"16","author":"Drake","year":"2006","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ergon.2018.06.003","article-title":"Surface electromyography for risk assessment in work activities designed using the \u201crevised NIOSH lifting equation\u201d","volume":"68","author":"Ranavolo","year":"2018","journal-title":"Int. J. Ind. Ergon."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1080\/00140139.2014.991764","article-title":"A new muscle co-activation index for biomechanical load evaluation in work activities","volume":"58","author":"Ranavolo","year":"2015","journal-title":"Ergonomics"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ranavolo, A., Draicchio, F., Varrecchia, T., Silvetti, A., and Iavicoli, S. (2018). Wearable monitoring devices for biomechanical risk assessment at work: Current status and future challenges\u2014A systematic review. Int. J. Environ. Res. Public Health, 15, Erratum in Int. J. Environ. Res. Public Health 2018, 15, 2569.","DOI":"10.3390\/ijerph15112569"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s001670000130","article-title":"Dynamic stability after ACL injury: Who can hop?","volume":"8","author":"Rudolph","year":"2000","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1050-6411(00)00025-0","article-title":"Comparison of algorithms for estimation of EMG variables during voluntary isometric contractions","volume":"10","author":"Farina","year":"2000","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/0021-9290(95)00003-Z","article-title":"An EMG-assisted model of trunk loading during free-dynamic lifting","volume":"28","author":"Granata","year":"1995","journal-title":"J. Biomech."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1123\/jab.13.2.135","article-title":"The use of surface electromyography in biomechanics","volume":"13","year":"1997","journal-title":"J. Appl. Biomech."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jelekin.2007.03.006","article-title":"Effect of elbow joint angle on force-EMG relationships in human elbow flexor and extensor muscles","volume":"18","author":"Doheny","year":"2008","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_44","first-page":"195","article-title":"The usefulness of mean and median frequencies in electromyography analysis","volume":"23","author":"Phinyomark","year":"2012","journal-title":"Comput. Intell. Electromyogr. Anal.-Perspect. Curr. Appl. Futur. Chall."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1242\/jeb.01042","article-title":"Spectral properties of myoelectric signals from different motor units in the leg extensor muscles","volume":"207","author":"Wakeling","year":"2004","journal-title":"J. Exp. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jelekin.2005.07.009","article-title":"Surface electromyography and peak torque of repetitive maximum isokinetic plantar flexions in relation to aspects of muscle morphology","volume":"16","author":"Larsson","year":"2006","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.clinbiomech.2009.01.010","article-title":"Surface EMG based muscle fatigue evaluation in biomechanics","volume":"24","author":"Cifrek","year":"2009","journal-title":"Clin. Biomech."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fneur.2019.00902","article-title":"Progressive Modular Rebalancing System and Visual Cueing for Gait Rehabilitation in Parkinson\u2019s Disease: A Pilot, Randomized, Controlled Trial with Crossover","volume":"10","author":"Serrao","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0141-5425(85)90021-4","article-title":"An hypothesis for the role of the spine in human locomotion: A challenge to current thinking","volume":"7","author":"Gracovetsky","year":"1985","journal-title":"J. Biomed. Eng."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.spinee.2013.07.442","article-title":"The effect of prior lumbar surgeries on the flexion relaxation phenomenon and its responsiveness to rehabilitative treatment","volume":"14","author":"Neblett","year":"2014","journal-title":"Spine J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100262","DOI":"10.1016\/j.wnsx.2023.100262","article-title":"Gait analysis, trunk movements, and electromyographic patterns after minimally invasive spine surgery for lumbar instability: An observational prospective study","volume":"21","author":"Miscusi","year":"2023","journal-title":"World Neurosurg. X"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s43390-021-00396-2","article-title":"Comparison of the postoperative changes in trunk and lower extremity muscle activities between patients with adult spinal deformity and age-matched controls using surface electromyography","volume":"10","author":"Banno","year":"2022","journal-title":"Spine Deform."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/a-0873-1557","article-title":"Movement Analysis in Orthopedics and Trauma Surgery\u2014Measurement Systems and Clinical Applications","volume":"158","author":"Oppelt","year":"2020","journal-title":"Z. Orthop. Unfall."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"968818","DOI":"10.3389\/fneur.2022.968818","article-title":"Indexes for motor performance assessment in job integration\/reintegration of people with neuromuscular disorders: A systematic review","volume":"13","author":"Chini","year":"2022","journal-title":"Front. Neurol."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/11\/3527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:51:01Z","timestamp":1760107861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/11\/3527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["s24113527"],"URL":"https:\/\/doi.org\/10.3390\/s24113527","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2024,5,30]]}}}