{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:05Z","timestamp":1760144945108,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC)","doi-asserted-by":"publisher","award":["758700"],"award-info":[{"award-number":["758700"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e9 Gustave Eiffel, CNRS, ESYCOM, UMR 9007 CNRS\/Universit\u00e9 Gustave Eiffel, F-77454 Marne-la-Vall\u00e9e, France","award":["758700"],"award-info":[{"award-number":["758700"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This paper demonstrates, for the first time, the stability of synthetic diamond as a passive layer within neural implants. Leveraging the exceptional biocompatibility of intrinsic nanocrystalline diamond, a comprehensive review of material aging analysis in the context of in-vivo implants is provided. This work is based on electric impedance monitoring through the formulation of an analytical model that scrutinizes essential parameters such as the deposited metal resistivity, insulation between conductors, changes in electrode geometry, and leakage currents. The evolution of these parameters takes place over an equivalent period of approximately 10 years. The analytical model, focusing on a fractional capacitor, provides nuanced insights into the surface conductivity variation. A comparative study is performed between a classical polymer material (SU8) and synthetic diamond. Samples subjected to dynamic impedance analysis reveal distinctive patterns over time, characterized by their physical degradation. The results highlight the very high stability of diamond, suggesting promise for the electrode\u2019s enduring viability. To support this analysis, microscopic and optical measurements conclude the paper and confirm the high stability of diamond and its strong potential as a material for neural implants with long-life use.<\/jats:p>","DOI":"10.3390\/s24113619","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:43:54Z","timestamp":1717577034000},"page":"3619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stability Study of Synthetic Diamond Using a Thermally Controlled Biological Environment: Application towards Long-Lasting Neural Prostheses"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0143-9642","authenticated-orcid":false,"given":"Jordan","family":"Roy","sequence":"first","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"given":"Umme Tabassum","family":"Sarah","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-8353","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Lissorgues","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-804X","authenticated-orcid":false,"given":"Olivier","family":"Fran\u00e7ais","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"given":"Abir","family":"Rezgui","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"given":"Patrick","family":"Poulichet","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-3037","authenticated-orcid":false,"given":"Hakim","family":"Takhedmit","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-6564","authenticated-orcid":false,"given":"Emmanuel","family":"Scorsone","sequence":"additional","affiliation":[{"name":"Diamond Sensors Laboratory, CEA-LIST, F-91190 Gif-sur-Yvette, France"}]},{"given":"Lionel","family":"Rousseau","sequence":"additional","affiliation":[{"name":"ESYCOM Laboratory for Electronics, Communication and Microsystems, CNRS UMR 9007, F-77454 Marne-la-Vall\u00e9e, France"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-023-06094-5","article-title":"Walking Naturally After Spinal Cord Injury Using a Brain\u2013spine Interface","volume":"618","author":"Lorach","year":"2023","journal-title":"Nature"},{"key":"ref_2","unstructured":"(2024, April 29). Blackrock Neurotech|Empowered by Thought. Available online: https:\/\/blackrockneurotech.com\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.21037\/atm-22-2858","article-title":"A Narrative Review of Cortical Visual Prosthesis Systems: The Latest Progress and Significance of Nanotechnology for the Future","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/coa.13963","article-title":"Detecting and Managing Partial Shorts in Cochlear Implants: A Validation of Scalp Surface Potential Testing","volume":"47","author":"Eitutis","year":"2022","journal-title":"Clin. Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/polb.22169","article-title":"Polymers for Neural Implants","volume":"49","author":"Hassler","year":"2011","journal-title":"J. Polym. Sci. Part B Polym. Phys."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Onken, A., Sch\u00fctte, H., Wulff, A., Lenz-Strauch, H., Kreienmeyer, M., Hild, S., Stieglitz, T., Gassmann, S., Lenarz, T., and Doll, T. (2022). Predicting Corrosion Delamination Failure in Active Implantable Medical Devices: Analytical Model and Validation Strategy. Bioengineering, 9.","DOI":"10.3390\/bioengineering9010010"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/natrevmats.2016.63","article-title":"Materials and Technologies for Soft Implantable Neuroprostheses","volume":"1","author":"Lacour","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2005786","DOI":"10.1002\/adma.202005786","article-title":"Emerging Materials and Technologies with Applications in Flexible Neural Implants: A Comprehensive Review of Current Issues with Neural Devices","volume":"33","author":"Cho","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Malisz, K., \u015awieczko-\u017burek, B., and Sionkowska, A. (2023). Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications\u2014A Review. Materials, 16.","DOI":"10.3390\/ma16093420"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"142435","DOI":"10.1016\/j.electacta.2023.142435","article-title":"Recent Advances in Modified Boron-doped Diamond Electrodes: A Review","volume":"456","author":"Matvieiev","year":"2023","journal-title":"Electrochim. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Purcell, E.K., Becker, M.F., Guo, Y., Hara, S.A., Ludwig, K.A., McKinney, C.J., Monroe, E.M., Rechenberg, R., Rusinek, C.A., and Saxena, A. (2021). Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities. Micromachines, 12.","DOI":"10.3390\/mi12020128"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"041007","DOI":"10.1088\/1741-2552\/ac1e45","article-title":"Carbon-based Neural Electrodes: Promises and Challenges","volume":"18","author":"Devi","year":"2021","journal-title":"J. Neural Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.carbon.2016.02.059","article-title":"Diamond for Neural Interfacing: A Review","volume":"102","author":"Garrett","year":"2016","journal-title":"Carbon"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20170382","DOI":"10.1098\/rsif.2017.0382","article-title":"Diamond thin films: Giving biomedical applications a new shine","volume":"14","author":"Nistor","year":"2017","journal-title":"J. R. Soc. Interface"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"066014","DOI":"10.1088\/1741-2560\/10\/6\/066014","article-title":"Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates","volume":"10","author":"Barrese","year":"2013","journal-title":"J. Neural Eng."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tintelott, M., Schander, A., and Lang, W. (2022). Understanding Electrical Failure of Polyimide-based Flexible Neural Implants: The Role of Thin Film Adhesion. Polymers, 14.","DOI":"10.3390\/polym14183702"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"026016","DOI":"10.1088\/1741-2560\/11\/2\/026016","article-title":"Long-term reliability of Al2O3 and Parylene C bilayer encapsulated Utah electrode array based neural interfaces for chronic implantation","volume":"11","author":"Xie","year":"2014","journal-title":"J. Neural Eng."},{"key":"ref_18","first-page":"92","article-title":"The effect of diamond dust alone and mixed with quartz on the lungs of rats","volume":"15","author":"King","year":"1958","journal-title":"Br. J. Ind. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1016\/j.biomaterials.2012.06.084","article-title":"The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent","volume":"33","author":"Vaijayanthimala","year":"2012","journal-title":"Biomaterials"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"17604","DOI":"10.1021\/ja0567081","article-title":"Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity","volume":"127","author":"Yu","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"23033","DOI":"10.3390\/ijms141123033","article-title":"Nano-nutrition of chicken embryos. The effect of in ovo administration of diamond nanoparticles and L-glutamine on molecular responses in chicken embryo pectoral muscles","volume":"14","author":"Grodzik","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zakrzewska, K.E., Samluk, A., Wierzbicki, M., Jaworski, S., Kutwin, M., Sawosz, E., Chwalibog, A., Pijanowska, D.G., and Pluta, K.D. (2015). Analysis of the cytotoxicity of carbon-based nanoparticles, diamond and graphite, in human glioblastoma and hepatoma cell lines. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122579"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jbm.b.30448","article-title":"In vitro and in vivo evaluation of ultrananocrystalline diamond for coating of implantable retinal microchips","volume":"77","author":"Xiao","year":"2006","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0925-9635(00)00217-X","article-title":"Phosphorus-doped chemical vapor deposition of diamond","volume":"9","author":"Koizumi","year":"2000","journal-title":"Diam. Relat. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41378-020-0155-1","article-title":"Flexible, Diamond-based Microelectrodes Fabricated Using the Diamond Growth Side for Neural Sensing","volume":"6","author":"Fan","year":"2020","journal-title":"Microsyst. Nanoeng."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wilfinger, C., Zhang, J., Nguyen, D., Degardin-Chicaud, J., Bergonzo, P., Picaud, S., Borda, E., Ghezzi, D., Scorsone, E., and Lissorgues, G. (2023). In Vivo Recording of Visually Evoked Potentials with Novel Full Diamond Ecog Implants, Elsevier.","DOI":"10.2139\/ssrn.4630713"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1515\/zpch-1889-0408","article-title":"\u00dcber die Dissociationsw\u00e4rme und den Einflu\u00df der Temperatur auf den Dissociationsgrad der Elektrolyte","volume":"4","author":"Arrhenius","year":"1889","journal-title":"Z. Phys. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1515\/zpch-1889-0416","article-title":"\u00dcber die Reaktionsgeschwindigkeit bei der Inversion von Rohrzucker durch S\u00e4uren","volume":"4","author":"Arrhenius","year":"1889","journal-title":"Z. Phys. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.medengphy.2008.06.001","article-title":"Accelerated aging for testing polymeric biomaterials and medical devices","volume":"30","author":"Hukins","year":"2008","journal-title":"Med. Eng. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"066002","DOI":"10.1088\/1741-2560\/13\/6\/066002","article-title":"Chronic in vivo stability assessment of carbon fiber microelectrode arrays","volume":"13","author":"Patel","year":"2016","journal-title":"J. Neural Eng."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1016\/j.biomaterials.2012.05.017","article-title":"Substrate dependent stability of conducting polymer coatings on medical electrodes","volume":"33","author":"Green","year":"2012","journal-title":"Biomaterials"},{"key":"ref_32","unstructured":"(2024, April 29). Standard Guide for Accelerated Aging of Sterile Barrier Systems for Medical Devices. Available online: https:\/\/www.astm.org\/f1980-16.html."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/df9470100011","article-title":"Kinetics of Rapid Electrode Reactions","volume":"1","author":"Randles","year":"1947","journal-title":"Discuss. Faraday Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1109\/MCAS.2010.938637","article-title":"Fractional-order Circuits and Systems: An Emerging Interdisciplinary Research Area","volume":"10","author":"Elwakil","year":"2010","journal-title":"IEEE Circuits Syst. Mag."},{"key":"ref_35","first-page":"29","article-title":"Modelling and Analysis of Fractional Capacitors","volume":"2","author":"Tripathy","year":"2015","journal-title":"Int. J. Eng. Appl. Sci. (IJEAS)"},{"key":"ref_36","first-page":"279","article-title":"The Origin and Status of the Arrhenius Equation","volume":"59","author":"Logan","year":"1982","journal-title":"Int. J. Eng. Appl. Sci. (IJEAS)"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1109\/TDMR.2019.2907080","article-title":"On Thermal Acceleration of Medical Device Polymer Aging","volume":"19","author":"Janting","year":"2019","journal-title":"IEEE Trans. Device Mater. Reliab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.diamond.2006.12.005","article-title":"On the Interaction of Molecular Hydrogen with Diamonds: An Experimental Study Using Nuclear Probes and Thermal Desorption","volume":"16","author":"Shiryaev","year":"2007","journal-title":"Diam. Relat. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"\u0141o\u015b, S., Fabisiak, K., Paprocki, K., Szybowicz, M., Dychalska, A., Spychaj-Fabisiak, E., and Frank\u00f3w, W. (2021). The Hydrogenation Impact on Electronic Properties of p-Diamond\/n-Si Heterojunctions. Materials, 14.","DOI":"10.3390\/ma14216615"},{"key":"ref_40","unstructured":"Wilfinger, C.A. (2023). Fabrication of Full Soft Diamond Implants for Functional Rehabilitation. [Ph.D. Thesis, Gustave Eiffel University]. NNT: 2023UEFL2025."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/26941112.2021.1877019","article-title":"Progress in Semiconductor Diamond Photodetectors and MEMS Sensors","volume":"1","author":"Liao","year":"2021","journal-title":"Funct. Diam."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e2800","DOI":"10.1002\/jnm.2800","article-title":"Microwave Diamond Devices Technology: Field-effect Transistors and Modeling","volume":"34","author":"Chen","year":"2021","journal-title":"Int. J. Numer. Model. Electron. Netw. Devices Fields"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108782","DOI":"10.1016\/j.diamond.2021.108782","article-title":"High Breakdown Voltage of Boron-doped Diamond Metal Semiconductor Field Effect Transistor Grown on Freestanding Heteroepitaxial Diamond Substrate","volume":"121","author":"Choi","year":"2022","journal-title":"Diam. Relat. Mater."},{"key":"ref_44","unstructured":"Cottance, M. (2014). Contribution to the Development of Neuro-Electric Interfaces. [Ph.D. Thesis, Paris-Est University]. NNT: 2014PEST1105."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/11\/3619\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:53:14Z","timestamp":1760107994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/11\/3619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":44,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["s24113619"],"URL":"https:\/\/doi.org\/10.3390\/s24113619","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2024,6,4]]}}}