{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:54:38Z","timestamp":1782604478658,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Ultrasound imaging (US) is being increasingly used to aid in the diagnosis of entrapment neuropathies. This study aims to evaluate the shear modulus and cross-sectional area (CSA) of the median nerve in patients with carpal tunnel syndrome (CTS). A total of 35 patients with CTS participated in the study. CSA and shear modulus testing were performed in shear wave elastography (SWE) mode in five positions of the right and left radiocarpal joints (intermediate position 0\u00b0, 45\u00b0 of extension, maximum extension, 45\u00b0 of flexion, and maximum flexion). There were significant side-to-side differences in the median nerve shear modulus at each wrist position as compared to the asymptomatic side. There were significant side-to-side differences in the median nerve CSA at each wrist position as compared to the asymptomatic side. Shear modulus increases in patients with CTS at different angular positions of flexion and extension of the radiocarpal joint. In individuals with CTS, the CSA of the median nerve is greater on the symptomatic side compared to the asymptomatic side. The CSA decreases in positions of maximum extension and 45\u00b0 of flexion and in maximum flexion relative to the resting position.<\/jats:p>","DOI":"10.3390\/s24144487","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T11:33:22Z","timestamp":1720697602000},"page":"4487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in Ultrasound Parameters of the Median Nerve at Different Positions of the Radiocarpal Joint in Patients with Carpal Tunnel Syndrome"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-757X","authenticated-orcid":false,"given":"Tomasz","family":"Wolny","sequence":"first","affiliation":[{"name":"Musculoskeletal Elastography and Ultrasonography Laboratory, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4504-1511","authenticated-orcid":false,"given":"Katarzyna","family":"Glibov","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Rehabilitation and Physical Medicine, Military Medical Academy, Memorial Teaching H of The Medical University of Lodz\u2014Central Veterans Hospital, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2430-875X","authenticated-orcid":false,"given":"Micha\u0142","family":"Wieczorek","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, The Health Center in Miko\u0142\u00f3w Ltd., 43-190 Miko\u0142\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Gnat","sequence":"additional","affiliation":[{"name":"Musculoskeletal Elastography and Ultrasonography Laboratory, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-8123","authenticated-orcid":false,"given":"Pawe\u0142","family":"Linek","sequence":"additional","affiliation":[{"name":"Musculoskeletal Elastography and Ultrasonography Laboratory, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"ref_1","first-page":"6","article-title":"Carpal tunnel syndrome","volume":"77","author":"Aroori","year":"2008","journal-title":"Ulst. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1388-2457(01)00704-0","article-title":"A new clinical scale of carpal tunnel syndrome: Validation of the measurement and clinicalneurophysiological assessment","volume":"113","author":"Giannini","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1054\/math.2000.0355","article-title":"An investigation to compare the effectiveness of carpal bone mobilisation and neurodynamic mobilisation as methods of treatment for carpal tunnel syndrome","volume":"5","author":"Rushton","year":"2000","journal-title":"Man. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population","volume":"282","author":"Atroshi","year":"1999","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0895-4356(92)90038-O","article-title":"Carpal tunnel syndrome: Prevalence in the general population","volume":"45","author":"Knipschild","year":"1992","journal-title":"J. Clin. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/(SICI)1097-4598(200002)23:2<211::AID-MUS11>3.0.CO;2-J","article-title":"Usefulness of hand rehabilitation after carpal tunnel surgery","volume":"23","author":"Provinciali","year":"2000","journal-title":"Muscle Nerve"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1539\/joh.15-0108-OA","article-title":"Two-point discrimination and kinesthetic sense disorders in productive age individuals with carpal tunnel syndrome","volume":"16","author":"Wolny","year":"2016","journal-title":"J. Occup. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jht.2016.10.003","article-title":"Overall health status in patients with mild to moderate carpal tunnel syndrome: A case-control study","volume":"30","author":"Wolny","year":"2017","journal-title":"J. Hand Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00420-006-0129-0","article-title":"Relationship between repetitive work and the prevalence of carpal tunnel syndrome in part-time and full-time female supermarket cashiers; a quasi-experimental study","volume":"80","author":"Bonfiglioli","year":"2007","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/jum.14417","article-title":"Use of Multiple Ultrasonographic Parameters in Confirmation of Carpal Tunnel Syndrome","volume":"37","author":"Azman","year":"2018","journal-title":"J. Ultrasound Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2147\/CIA.S177307","article-title":"The diagnostic accuracy of median nerve ultrasonography in elderly patients with carpal tunnel syndrome: Sensitivity and specificity assessment","volume":"13","author":"Roghani","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.55519\/JAMC-02-9892","article-title":"Assessment of Carpal Tunnel Syndrome with Ultrasonography","volume":"34","author":"Ahmed","year":"2022","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002060-199302000-00001","article-title":"Diagnosis of carpal tunnel syndrome the gold standard","volume":"72","author":"Johnson","year":"1993","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: Clinical features, diagnosis, and management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S1388-2457(02)00169-4","article-title":"Carpal tunnel syndrome: Pathophysiology and clinical neurophysiology","volume":"113","author":"Werner","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejrad.2005.05.013","article-title":"The value of ultrasonographic measurement in carpal tunnel syndrome in patients with negative electrodiagnostic tests","volume":"56","author":"Koyuncuoglu","year":"2005","journal-title":"Eur. J. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/mus.20019","article-title":"Carpal tunnel syndrome with normal nerve conduction studies","volume":"29","author":"Witt","year":"2004","journal-title":"Muscle Nerve"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.2106\/JBJS.G.01362","article-title":"The value added by electrodiagnostic testing in the diagnosis of carpal tunnel syndrome","volume":"90","author":"Graham","year":"2008","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jht.2021.04.014","article-title":"The role of diagnostic ultrasound in the examination of carpal tunnel syndrome: An update and systematic review","volume":"35","author":"Erickson","year":"2022","journal-title":"J. Hand Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/17531934211059808","article-title":"Ultrasonography for the diagnosis of carpal tunnel syndrome: Correlation of clinical symptoms, cross-sectional areas and electroneuromyography","volume":"47","author":"Ratasvouri","year":"2022","journal-title":"J. Hand Surg. Eur. Vol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.7863\/ultra.15.01069","article-title":"Reliability Assessment of Various Sonographic Techniques for Evaluating Carpal Tunnel Syndrome","volume":"34","author":"Junc","year":"2015","journal-title":"J. Ultrasound Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1002\/jum.15012","article-title":"Diagnostic Accuracy of Ultrasound Parameters in Carpal Tunnel Syndrome","volume":"38","author":"Fidel","year":"2019","journal-title":"J. Ultrasound Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1007\/s00330-015-3649-8","article-title":"Sonographic crosssectional area measurement in carpal tunnel syndrome patients: Can delta and ratio calculations predict severity compared to nerve conduction studies?","volume":"25","author":"Klauser","year":"2015","journal-title":"Eur. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.ultrasmedbio.2013.02.016","article-title":"Ultrasound elastographic evaluation in the diagnosis of carpal tunnel syndrome: Initial findings","volume":"39","author":"Orman","year":"2013","journal-title":"Ultrasound Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00330-013-3023-7","article-title":"Median nerve stiffness measurement by shear wave elastography: A potential sonographic method in the diagnosis of carpal tunnel syndrome","volume":"24","author":"Kantarci","year":"2014","journal-title":"Eur. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.acra.2020.08.011","article-title":"Diagnosis of Carpal Tunnel Syndrome using Shear Wave Elastography and High-frequency Ultrasound Imaging","volume":"28","author":"Nam","year":"2021","journal-title":"Acad. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jhsa.2006.01.020","article-title":"The use of diagnostic ultrasound in carpal tunnel syndrome","volume":"31","author":"Wiesler","year":"2006","journal-title":"J. Hand Surg. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/mus.10276","article-title":"Ultrasonographic measurement of median nerve cross-sectional area in idiopathic carpal tunnel syndrome: Diagnostic accuracy","volume":"26","author":"Nakamichi","year":"2002","journal-title":"Muscle Nerve"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/8756479319898471","article-title":"Comparing Shape Categorization to Circularity Measurement in the Evaluation of Median Nerve Compression Using Sonography","volume":"36","author":"Yao","year":"2020","journal-title":"J. Diagn. Med. Sonogr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wolny, T., Fern\u00e1ndez-De-Las-Pe\u00f1as, C., Granek, A., and Linek, P. (2022). Changes in Ultrasound Measurements of the Ulnar Nerve at Different Elbow Joint Positions in Patients with Cubital Tunnel Syndrome. Sensors, 22.","DOI":"10.3390\/s22218354"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"638","DOI":"10.5114\/pjr.2021.111437","article-title":"Application of shear wave elastography and median nerve cross-section area in the diagnosis and staging of carpal tunnel syndrome: A case-control study","volume":"86","author":"Mohammadi","year":"2021","journal-title":"Pol. J. Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2106\/00004623-198163030-00009","article-title":"The carpal tunnel syndrome. A study of carpal canal pressures","volume":"63","author":"Gelberman","year":"1981","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2106\/00004623-199511000-00008","article-title":"Position of the wrist associated with the lowest carpal-tunnel pressure: Implications for splint design","volume":"77","author":"Weiss","year":"1995","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.apmr.2007.07.019","article-title":"Efficacy of a fabricated customized splint and tendon and nerve gliding exercises for the treatment of carpal tunnel syndrome: A randomized controlled trial","volume":"88","author":"Brininger","year":"2007","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1148\/rg.2017160116","article-title":"Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications","volume":"37","author":"Taljanovic","year":"2017","journal-title":"Radiographics"},{"key":"ref_36","first-page":"65","article-title":"A Simple Sequentially Rejective Multiple Test Procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00256-022-04143-0","article-title":"Shear wave elastography is a valuable tool for diagnosing and grading carpal tunnel syndrome","volume":"52","author":"Sernik","year":"2023","journal-title":"Sceletal Radiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.clinbiomech.2006.04.008","article-title":"An MRI evaluation of carpal tunnel dimensions in healthy wrists: Implications for carpal tunnel syndrome","volume":"21","author":"Bower","year":"2006","journal-title":"Clin. Biomech."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Anderson, D.A., Oliver, M.L., and Gordon, K.D. (2022). Carpal tunnel volume distribution and morphology changes with flexion-extension and radial-ulnar deviation wrist postures. PLoS ONE, 30.","DOI":"10.1016\/j.clinbiomech.2022.105575"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.2106\/00004623-199612000-00013","article-title":"Excursion and strain of the median nerve","volume":"78","author":"Wright","year":"1996","journal-title":"I Bone Jt. Surg. Am."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1054\/jhsb.2001.0582","article-title":"The use of ultrasound imaging to demonstrate reduced movement of the median nerve during wrist flexion in patients with non-specific arm pain","volume":"26","author":"Greening","year":"2001","journal-title":"J. Hand Surg. Br."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1054\/jhsb.2000.0453","article-title":"Peripheral nerve motion measurement with spectral Doppler sonography: A reliability study","volume":"25","author":"Hough","year":"2000","journal-title":"J. Hand Surg. Br."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0266-7681(03)00107-4","article-title":"Longitudinal sliding of the median nerve in patients with carpal tunnel syndrome","volume":"28","author":"Erel","year":"2003","journal-title":"J. Hand Surg. Br."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ultrasmedbio.2012.02.026","article-title":"Ultrasonography for diagnosing carpal tunnel syndrome: A meta-analysis of diagnostic test accuracy","volume":"38","author":"Tai","year":"2012","journal-title":"Ultrasound Med. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.2106\/JBJS.M.01250","article-title":"Comparison of ultrasound and electrodiagnostic testing for diagnosis of carpal tunnel syndrome: Study using a validated clinical tool as the reference standard","volume":"96","author":"Fowler","year":"2014","journal-title":"J. Bone Jt. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/rheumatology\/keh190","article-title":"Ultrasonography versus nerve conduction study in patients with carpal tunnel syndrome: Substantive or complementary tests?","volume":"43","author":"Aty","year":"2004","journal-title":"Rheumatology"},{"key":"ref_47","first-page":"111","article-title":"Diagnostic Accuracy of Integrating Ultrasound and Shear Wave Elastography in Assessing Carpal Tunnel Syndrome Severity: A Prospective Observational Study","volume":"16","author":"Almalki","year":"2024","journal-title":"Orthop. Res. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/jum.16450","article-title":"Median Nerve Shear Wave Elastography Is Associated with the Neurophysiological Severity of Carpal Tunnel Syndrome","volume":"43","author":"Martikkala","year":"2024","journal-title":"J. Ultrasound Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Prakash, A., Vinutha, H., Janardhan, D.C., Mouna, R.M., Sushmitha, P.S., Sajjan, S., and Samanvitha, H. (Skelet. Radiol., 2024). Diagnostic efficacy of high-frequency Grey-scale ultrasonography and Sono-elastography in grading the severity of carpal tunnel syndrome in comparison to nerve conduction studies, Skelet. Radiol., online ahead of print.","DOI":"10.1007\/s00256-024-04662-y"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jbmt.2023.01.001","article-title":"The sono-elastography evaluation of the immediate effects of neurodynamic mobilization technique on median nerve stiffness in patients with carpal tunnel syndrome","volume":"36","author":"Khademi","year":"2023","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Wu, H., Zhao, H.J., Xue, W.L., Wang, Y.C., Zhang, W.Y., and Wang, X.L. (2022). Ultrasound and elastography role in pre- and post-operative evaluation of median neuropathy in patients with carpal tunnel syndrome. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1079737"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/14\/4487\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:15:10Z","timestamp":1760109310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/14\/4487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":51,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["s24144487"],"URL":"https:\/\/doi.org\/10.3390\/s24144487","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,11]]}}}