{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:23:08Z","timestamp":1772907788012,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR Biomedical Research Centre at South London"},{"name":"Maudsley NHS Foundation Trust and King\u2019s College London"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>IoT sensors offer a wide range of sensing capabilities, many of which have potential health applications. Existing solutions for IoT in healthcare have notable limitations, such as closed-source, limited I\/O protocols, limited cloud platform support, and missing specific functionality for health use cases. Developing an open-source internet of things (IoT) gateway solution that addresses these limitations and provides reliability, broad applicability, and utility is highly desirable. Combining a wide range of sensor data streams from IoT devices with ambulatory mHealth data would open up the potential to provide a detailed 360-degree view of the relationship between patient physiology, behavior, and environment. We have developed RADAR-IoT as an open-source IoT gateway framework, to harness this potential. It aims to connect multiple IoT devices at the edge, perform limited on-device data processing and analysis, and integrate with cloud-based mobile health platforms, such as RADAR-base, enabling real-time data processing. We also present a proof-of-concept data collection from this framework, using prototype hardware in two locations. The RADAR-IoT framework, combined with the RADAR-base mHealth platform, provides a comprehensive view of a user\u2019s health and environment by integrating static IoT sensors and wearable devices. Despite its current limitations, it offers a promising open-source solution for health research, with potential applications in managing infection control, monitoring chronic pulmonary disorders, and assisting patients with impaired motor control or cognitive ability.<\/jats:p>","DOI":"10.3390\/s24144614","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T15:15:19Z","timestamp":1721229319000},"page":"4614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RADAR-IoT: An Open-Source, Interoperable, and Extensible IoT Gateway Framework for Health Research"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-3120","authenticated-orcid":false,"given":"Yatharth","family":"Ranjan","sequence":"first","affiliation":[{"name":"Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AF, UK"}]},{"given":"Jiangeng","family":"Chang","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9126-5615","authenticated-orcid":false,"given":"Heet","family":"Sankesara","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AF, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-0915","authenticated-orcid":false,"given":"Pauline","family":"Conde","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AF, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-9920","authenticated-orcid":false,"given":"Zulqarnain","family":"Rashid","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AF, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-9245","authenticated-orcid":false,"given":"Richard J. B.","family":"Dobson","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AF, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-1927","authenticated-orcid":false,"given":"Amos","family":"Folarin","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AF, UK"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","unstructured":"Younas, M., Awan, I., and Gr\u00f8nli, T.M. (2023). Harnessing the Digital Revolution: A Comprehensive Review of mHealth Applications for Remote Monitoring in Transforming Healthcare Delivery. International Conference on Mobile Web and Intelligent Information Systems, Springer Nature."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"(2024, June 26). Just-in-Time Adaptive Interventions (JITAIs) in Mobile Health: Key Components and Design Principles for Ongoing Health Behavior Support|Annals of Behavioral Medicine|Oxford Academic. Available online: https:\/\/academic.oup.com\/abm\/article\/52\/6\/446\/4733473.","DOI":"10.1007\/s12160-016-9830-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s40537-019-0268-2","article-title":"Internet of Things is a revolutionary approach for future technology enhancement: A review","volume":"6","author":"Kumar","year":"2019","journal-title":"J. Big Data"},{"key":"ref_4","unstructured":"(2023, May 15). What Is an IoT Gateway and How Do I Keep It Secure?. Available online: https:\/\/www.globalsign.com\/en\/blog\/what-is-an-iot-gateway-device."},{"key":"ref_5","unstructured":"(2023, May 15). Internet of Things in Healthcare Market Size Report. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/internet-of-things-iot-healthcare-market."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.36965\/OJAKM.2016.4(2)128-145","article-title":"Physicians\u2019 attitudes toward the use of IoT medical devices as part of their practice","volume":"4","author":"Haiman","year":"2016","journal-title":"Online J. Appl. Knowl. Manag. (OJAKM)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1109\/ACCESS.2020.3047960","article-title":"A Comprehensive Survey of the Internet of Things (IoT) and AI-Based Smart Healthcare","volume":"9","author":"Alshehri","year":"2021","journal-title":"IEEE Access"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1109\/ACCESS.2015.2437951","article-title":"The Internet of Things for Health Care: A Comprehensive Survey","volume":"3","author":"Islam","year":"2015","journal-title":"IEEE Access"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e11734","DOI":"10.2196\/11734","article-title":"RADAR-Base: Open Source Mobile Health Platform for Collecting, Monitoring, and Analyzing Data Using Sensors, Wearables, and Mobile Devices","volume":"7","author":"Ranjan","year":"2019","journal-title":"JMIR mHealth uHealth"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s10072-020-04519-x","article-title":"Real-time assessment of COVID-19 prevalence among multiple sclerosis patients: A multicenter European study","volume":"41","author":"Leocani","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e19992","DOI":"10.2196\/19992","article-title":"Using Smartphones and Wearable Devices to Monitor Behavioral Changes during COVID-19","volume":"22","author":"Sun","year":"2020","journal-title":"J. Med. Internet Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e32587","DOI":"10.2196\/32587","article-title":"Investigating the Use of Digital Health Technology to Monitor COVID-19 and Its Effects: Protocol for an Observational Study (Covid Collab Study)","volume":"10","author":"Stewart","year":"2021","journal-title":"JMIR Res. Protoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e28873","DOI":"10.2196\/28873","article-title":"Remote Assessment of Lung Disease and Impact on Physical and Mental Health (RALPMH): Protocol for a Prospective Observational Study","volume":"10","author":"Ranjan","year":"2021","journal-title":"JMIR Res. Protoc."},{"key":"ref_14","unstructured":"(2023, May 15). Case Studies. Available online: https:\/\/radar-base.org\/case-studies\/."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ranjan, Y., Sankesara, H., Conde, P., Chang, J., Rashid, Z., Dobson, R.J., and A Folarin, A. (2023). RADAR-IoT: An Open-Source, Interoperable and Extensible IoT Gateway Framework for Healthcare and Beyond. Adjunct Proceedings of the 2022 ACM International Joint Conference on Pervasive and Ubiquitous Computing and the 2022 ACM International Symposium on Wearable Computers, Association for Computing Machinery. UbiComp\/ISWC\u201922 Adjunct.","DOI":"10.1145\/3544793.3560318"},{"key":"ref_16","unstructured":"(2023, May 15). IoT Medical Device Gateway\u2014Remote Patient Monitoring|Lantronix. Available online: https:\/\/www.lantronix.com\/solutions\/healthcare\/."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kesavan, S., and Kalambettu, G.K. (2018, January 9\u201310). IOT enabled comprehensive, plug and play gateway framework for smart health. Proceedings of the 2018 Second International Conference on Advances in Electronics, Computers and Communications (ICAECC), Bangalore, India.","DOI":"10.1109\/ICAECC.2018.8479431"},{"key":"ref_18","unstructured":"(2022, November 24). IoT Edge Framework. Available online: https:\/\/esf.eurotech.com\/docs\/edge-computing-platform."},{"key":"ref_19","unstructured":"(2022, November 24). Eclipse Kura\u2122 Documentation. Available online: http:\/\/eclipse.github.io\/kura\/docs-release-5.2\/."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lee, Y.H., and Nair, S. (2016, January 15\u201318). A Smart Gateway Framework for IOT Services. Proceedings of the 2016 IEEE International Conference on Internet of Things (iThings) and IEEE Green Computing and Communications (GreenCom) and IEEE Cyber, Physical and Social Computing (CPSCom) and IEEE Smart Data (SmartData), Chengdu, China.","DOI":"10.1109\/iThings-GreenCom-CPSCom-SmartData.2016.44"},{"key":"ref_21","unstructured":"(2022, November 25). ubiworx IoT Gateway Software Framework. Available online: https:\/\/ubiworx.com\/legal\/2-general\/34-ubiworx-iot-gateway-software-framework."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Adesina, T., and Osasona, O. (2019, January 15\u201318). A Novel Cognitive IoT Gateway Framework: Towards a Holistic Approach to IoT Interoperability. Proceedings of the 2019 IEEE 5th World Forum on Internet of Things (WF-IoT), Limerick, Ireland.","DOI":"10.1109\/WF-IoT.2019.8767248"},{"key":"ref_23","unstructured":"(2022, November 25). DeviceHive Overview. Available online: https:\/\/docs.devicehive.com\/docs."},{"key":"ref_24","unstructured":"(2022, November 25). ThingSpeak Documentation\u2014MathWorks United Kingdom. Available online: https:\/\/uk.mathworks.com\/help\/thingspeak\/index.html?s_tid=CRUX_lftnav."},{"key":"ref_25","unstructured":"(2022, November 25). Thinger Overview. Available online: https:\/\/docs.thinger.io\/."},{"key":"ref_26","unstructured":"(2022, November 25). Home Zettajs\/Zetta Wiki. Available online: https:\/\/github.com\/zettajs\/zetta."},{"key":"ref_27","unstructured":"(2022, November 25). OpenRemote|The 100% Open Source IoT Platform. Available online: https:\/\/www.openremote.io\/."},{"key":"ref_28","unstructured":"(2022, November 25). ThingsBoard IoT Gateway. Available online: https:\/\/github.com\/thingsboard\/thingsboard-gateway."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1109\/JIOT.2015.2498900","article-title":"Middleware for Internet of Things: A Survey","volume":"3","author":"Razzaque","year":"2016","journal-title":"IEEE Internet Things J."},{"key":"ref_30","unstructured":"(2023, May 15). Publish\u2013Subscribe Pattern. Available online: https:\/\/en.wikipedia.org\/w\/index.php?title=Publish%E2%80%93subscribe_pattern&oldid=1141729418."},{"key":"ref_31","unstructured":"(2023, May 15). Ltd, Raspberry Pi Buy a Raspberry Pi Zero. Available online: https:\/\/www.raspberrypi.com\/products\/raspberry-pi-zero\/."},{"key":"ref_32","unstructured":"Liang, S., Huang, C.Y., and Khalafbeigi, T. (2023, May 15). OGC SensorThings API Part 1: Sensing. Available online: https:\/\/docs.opengeospatial.org\/is\/15-078r6\/15-078r6.html."},{"key":"ref_33","unstructured":"(2023, May 15). InfluxDB Time Series Platform. Available online: https:\/\/www.influxdata.com\/products\/influxdb\/."},{"key":"ref_34","unstructured":"(2023, May 15). grafana\/grafana. Available online: https:\/\/github.com\/grafana\/grafana."},{"key":"ref_35","unstructured":"(2023, May 15). Redis. Available online: https:\/\/redis.io\/."},{"key":"ref_36","unstructured":"(2023, May 15). MQTT\u2014The Standard for IoT Messaging. Available online: https:\/\/mqtt.org\/."},{"key":"ref_37","unstructured":"(2023, May 15). Node-RED. Available online: https:\/\/github.com\/node-red\/node-red."},{"key":"ref_38","unstructured":"(2023, May 15). Apache Kafka. Available online: https:\/\/kafka.apache.org\/."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gu, Z., Wang, Y., Shi, W., Tian, Z., Ren, K., and Lau, F.C.M. (2019). A Practical Neighbor Discovery Framework for Wireless Sensor Networks. Sensors, 19.","DOI":"10.3390\/s19081887"},{"key":"ref_40","unstructured":"(2023, May 15). Object-Oriented Programming. Available online: https:\/\/en.wikipedia.org\/w\/index.php?title=Object-oriented_programming&oldid=1154120068."},{"key":"ref_41","unstructured":"(2023, May 15). GrovePi Plus|Seeed Studio Wiki. Available online: https:\/\/wiki.seeedstudio.com\/GrovePi_Plus\/."},{"key":"ref_42","unstructured":"(2023, May 15). OAuth 2.0\u2014OAuth. Available online: https:\/\/oauth.net\/2\/."},{"key":"ref_43","unstructured":"(2023, May 15). Avro Documentation. Available online: https:\/\/avro.apache.org\/docs\/."},{"key":"ref_44","unstructured":"(2023, May 15). Schema Registry. Available online: https:\/\/github.com\/confluentinc\/schema-registry."},{"key":"ref_45","unstructured":"(2024, June 26). tinyML. Available online: https:\/\/www.tinyml.org\/."},{"key":"ref_46","unstructured":"(2024, June 26). node-red-contrib-datakitjs. Available online: http:\/\/flows.nodered.org\/node\/node-red-contrib-datakitjs."},{"key":"ref_47","unstructured":"(2024, June 26). node-red-contrib-machine-learning. Available online: http:\/\/flows.nodered.org\/node\/node-red-contrib-machine-learning."},{"key":"ref_48","unstructured":"(2024, June 26). Node-RED ML Flows (Collection)\u2014Node-RED. Available online: https:\/\/flows.nodered.org\/collection\/nRKXqYoATZfZ."},{"key":"ref_49","unstructured":"(2024, June 26). Anamoly Detection Using Node-Red-Contrib-Industrial-Machine-Forecast (Flow)\u2014Node-RED. Available online: https:\/\/flows.nodered.org\/flow\/05bb091acda87d6b5803e54c122837bb."},{"key":"ref_50","unstructured":"(2023, May 15). Nebula Docker Orchestrator for IoT & Distributed Systems. Available online: https:\/\/nebula-orchestrator.github.io\/."},{"key":"ref_51","unstructured":"(2023, May 15). Dataplicity. Available online: https:\/\/www.dataplicity.com\/."},{"key":"ref_52","unstructured":"(2023, May 15). netdata\/netdata: Real-Time Performance Monitoring, Done Right!. Available online: https:\/\/github.com\/netdata\/netdata."},{"key":"ref_53","unstructured":"(2024, July 09). RADAR-IoT\/Docker\/Production at Master RADAR-Base\/RADAR-IoT. Available online: https:\/\/github.com\/RADAR-base\/RADAR-IoT\/tree\/master\/docker\/production."},{"key":"ref_54","unstructured":"(2024, July 09). Configurations RADAR-Base\/RADAR-IoT Wiki GitHub. Available online: https:\/\/github.com\/RADAR-base\/RADAR-IoT\/wiki\/Configurations."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2307\/1412159","article-title":"The Proof and Measurement of Association between Two Things","volume":"15","author":"Spearman","year":"1904","journal-title":"Am. J. Psychol."},{"key":"ref_56","unstructured":"(2023, May 15). Grove\u2014Air Quality Sensor v1.3|Seeed Studio Wiki. Available online: https:\/\/wiki.seeedstudio.com\/Grove-Air_Quality_Sensor_v1.3\/."},{"key":"ref_57","unstructured":"(2023, May 15). Grove\u2014Temperature&Humidity Sensor (DHT11)|Seeed Studio Wiki. Available online: https:\/\/wiki.seeedstudio.com\/Grove-TemperatureAndHumidity_Sensor\/."},{"key":"ref_58","unstructured":"(2023, May 15). Grove\u2014PIR Motion Sensor|Seeed Studio Wiki. Available online: https:\/\/wiki.seeedstudio.com\/Grove-PIR_Motion_Sensor\/."},{"key":"ref_59","unstructured":"(2023, May 15). Grove\u2014Light Sensor|Seeed Studio Wiki. Available online: https:\/\/wiki.seeedstudio.com\/Grove-Light_Sensor\/."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Braithwaite, I., Zhang, S., Kirkbride, J.B., Osborn, D.P.J., and Hayes, J.F. (2019). Air Pollution (Particulate Matter) Exposure and Associations with Depression, Anxiety, Bipolar, Psychosis and Suicide Risk: A Systematic Review and Meta-Analysis. Environ. Health Perspect., 127.","DOI":"10.1289\/EHP4595"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"124001","DOI":"10.1088\/1748-9326\/ac30c1","article-title":"Has the ultra low emission zone in London improved air quality?","volume":"16","author":"Ma","year":"2021","journal-title":"Environ. Res. Lett."},{"key":"ref_62","unstructured":"(2023, August 21). London Air Quality Network: Welcome to the London Air Quality Network Statistics Maps. Available online: https:\/\/www.londonair.org.uk\/london\/asp\/reportdetail.asp?ReportID=2019laqnr&ReportType=LAQN_Annual_Report."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Stavropoulos, T.G., Papastergiou, A., Mpaltadoros, L., Nikolopoulos, S., and Kompatsiaris, I. (2020). IoT Wearable Sensors and Devices in Elderly Care: A Literature Review. Sensors, 20.","DOI":"10.3390\/s20102826"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Calvillo-Arbizu, J., Rom\u00e1n-Mart\u00ednez, I., and Reina-Tosina, J. (2021). Internet of things in health: Requirements, issues, and gaps. Comput. Methods Programs Biomed., 208.","DOI":"10.1016\/j.cmpb.2021.106231"},{"key":"ref_65","unstructured":"Ranjan, Y. (2024, July 01). RADAR-IoT Proof of Concept (PoC). Available online: https:\/\/ieee-dataport.org\/documents\/radar-iot-proof-concept-poc."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/14\/4614\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:18:00Z","timestamp":1760109480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/14\/4614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":65,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["s24144614"],"URL":"https:\/\/doi.org\/10.3390\/s24144614","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]}}}