{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:14:54Z","timestamp":1775859294290,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RF-2019-12370198"],"award-info":[{"award-number":["RF-2019-12370198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Digital therapeutics refers to smartphone applications, software, and wearable devices that provide digital solutions to improve healthcare delivery. We developed a digital platform to support the GYM (Grow Your Muscle) study, an ongoing 48-week randomized, controlled trial on reduction of sarcopenia through a home-based, app-monitored physical exercise intervention. The GYM platform consists of a smartphone application including the exercise program and video tutorials of body-weight exercises, a wearable device to monitor heart rate during training, and a website for downloading training data to remotely monitor the exercise. The aim of this paper is to describe the platform in detail and to discuss the technical issues emerging during the study and those related to usability of the smartphone application through a retrospective survey. The main technical issue concerned the API level 33 upgrade, which did not enable participants using the Android operating systems to use the wearable device. The survey revealed some problems with viewing the video tutorials and with internet or smartphone connection. On the other hand, the smartphone application was reported to be easy to use and helpful to guide home exercising. Despite the issues encountered during the study, this digital-supported physical exercise intervention could provide useful to improve muscle measures of sarcopenia.<\/jats:p>","DOI":"10.3390\/s24154788","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T10:46:20Z","timestamp":1721817980000},"page":"4788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Digital Platform for Home-Based Exercise Prescription for Older People with Sarcopenia"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-7957","authenticated-orcid":false,"given":"Matteo","family":"Bonato","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via Giuseppe Colombo 71, 20133 Milan, Italy"},{"name":"Laboratory of Movement and Sport Sciences (LaMSS), IRCCS Istituto Ortopedico Galeazzi, Via Cristina da Belgioioso 173, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-0686","authenticated-orcid":false,"given":"Federica","family":"Marmondi","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Stamira d\u2019Ancona 20, 20127 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Mastropaolo","sequence":"additional","affiliation":[{"name":"Visionage s.r.l., Via Guglielmo Marconi 19, 70011 Alberobello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Inzaghi","sequence":"additional","affiliation":[{"name":"Laboratory of Movement and Sport Sciences (LaMSS), IRCCS Istituto Ortopedico Galeazzi, Via Cristina da Belgioioso 173, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Cerizza","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Stamira d\u2019Ancona 20, 20127 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-0290","authenticated-orcid":false,"given":"Laura","family":"Galli","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Stamira d\u2019Ancona 20, 20127 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9578-5338","authenticated-orcid":false,"given":"Giuseppe","family":"Banfi","sequence":"additional","affiliation":[{"name":"Laboratory of Movement and Sport Sciences (LaMSS), IRCCS Istituto Ortopedico Galeazzi, Via Cristina da Belgioioso 173, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-5957","authenticated-orcid":false,"given":"Paola","family":"Cinque","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Stamira d\u2019Ancona 20, 20127 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Flatt, T., and Partridge, L. (2018). Horizons in the evolution of aging. BMC Biol., 16.","DOI":"10.1186\/s12915-018-0562-z"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"The Lancet Healthy Longevity (2022). Ageing populations: Unaffordable demography. Lancet Healthy Longev., 3, e804.","DOI":"10.1016\/S2666-7568(22)00272-0"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: From molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1301\/nr.2003.may.157-167","article-title":"Sarcopenia and Aging","volume":"61","author":"Kamel","year":"2003","journal-title":"Nutr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e29744","DOI":"10.1097\/MD.0000000000029744","article-title":"Interrelationship among thigh intermuscular adipose tissue, cross-sectional area, muscle strength, and functional mobility in older subjects","volume":"101","author":"Borghi","year":"2022","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/aje\/kwf023","article-title":"Associations of Body Composition with Physical Performance and Self-reported Functional Limitation in Elderly Men and Women","volume":"156","author":"Sternfeld","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.5152\/iao.2020.8287","article-title":"Aging and the Relationship between Balance Performance, Vestibular Function and Somatosensory Thresholds","volume":"16","author":"Johnson","year":"2020","journal-title":"J. Int. Adv. Otol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.7861\/clinmedicine.14-2-183","article-title":"Sarcopenia","volume":"14","author":"Landi","year":"2014","journal-title":"Clin. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"afae052","DOI":"10.1093\/ageing\/afae052","article-title":"The Conceptual Definition of Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS)","volume":"53","author":"Cawthon","year":"2024","journal-title":"Age Ageing"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jamda.2016.06.001","article-title":"Sarcopenia Is Recognized as an Independent Condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) Code","volume":"17","author":"Cao","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: A systematic review and meta-analysis","volume":"13","author":"Balntzi","year":"2022","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"155711","DOI":"10.1016\/j.metabol.2023.155711","article-title":"Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors","volume":"149","author":"Aslam","year":"2023","journal-title":"Metabolism"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jbspin.2018.08.001","article-title":"Sarcopenia","volume":"86","author":"Tournadre","year":"2019","journal-title":"Jt. Bone Spine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.clnu.2018.09.026","article-title":"Financial impact of sarcopenia or low muscle mass\u2014A short review","volume":"38","author":"Norman","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1007\/s12603-018-1139-9","article-title":"International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management","volume":"22","author":"Dent","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s00421-022-04951-1","article-title":"Wearable activity trackers\u2013advanced technology or advanced marketing?","volume":"122","author":"Shei","year":"2022","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4103\/jfmpc.jfmpc_105_20","article-title":"Role of digital therapeutics and the changing future of healthcare","volume":"9","author":"Dang","year":"2020","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1038\/d41586-019-02873-1","article-title":"The emerging world of digital therapeutics","volume":"573","author":"Makin","year":"2019","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Natalucci, V., Marmondi, F., Biraghi, M., and Bonato, M. (2023). The Effectiveness of Wearable Devices in Non-Communicable Diseases to Manage Physical Activity and Nutrition: Where We Are?. Nutrients, 15.","DOI":"10.3390\/nu15040913"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcsm.12159","article-title":"Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: What are we really estimating?","volume":"8","author":"Gonzalez","year":"2017","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhsa.2008.01.008","article-title":"Grip Strength in Healthy Caucasian Adults: Reference Values","volume":"33","author":"Rickert","year":"2008","journal-title":"J. Hand Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/02701367.1999.10608028","article-title":"A 30-s Chair-Stand Test as a Measure of Lower Body Strength in Community-Residing Older Adults","volume":"70","author":"Jones","year":"1999","journal-title":"Res. Q. Exerc. Sport"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2340\/16501977-0537","article-title":"Using psychometric techniques to improve the Balance Evaluation Systems Test: The mini-BESTest","volume":"42","author":"Franchignoni","year":"2010","journal-title":"J. Rehabil. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"American Toracic Society (ATS) Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002). ATS statement: Guidelines for the six-minute walk test. Am. J. Respir. Crit. Care Med., 166, 111\u2013117.","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref_27","unstructured":"Reitan, R.M., and Wolfson, D. (1993). The Halstead Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation, Neuropsychology Press. [2nd ed.]."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (1997). Wechsler\u2019s Adult Intelligence Scale, American Psychological Association (APA). [3rd ed.]. Testing Booklet.","DOI":"10.1037\/t49755-000"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Reilly, T., and Atkinson, G. (2009). Effects of the Zone-Diet on Training Parameters in Recreational Master Athletes. Contemporary Sport, Leisure and Ergonomics, Routledge.","DOI":"10.4324\/9780203892459"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity","volume":"34","author":"Ware","year":"1996","journal-title":"Med. Care"},{"key":"ref_31","first-page":"149","article-title":"Predictive Accuracy of the Veterans Aging Cohort Study Index for Mortality with HIV Infection: A north American cross cohort analysis","volume":"62","author":"Teams","year":"2013","journal-title":"Am. J. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1249\/MSS.0b013e318213fefb","article-title":"American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise","volume":"43","author":"Garber","year":"2011","journal-title":"Med. Sci. Sport. Exerc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jcsm.13225","article-title":"Exercise for sarcopenia in older people: A systematic review and network meta-analysis","volume":"14","author":"Shen","year":"2023","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jsams.2006.06.020","article-title":"Retention, adherence and compliance: Important considerations for home- and group-based resistance training programs for older adults","volume":"9","author":"Cyarto","year":"2006","journal-title":"J. Sci. Med. Sport"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bonato, M., Marmondi, F., Turrini, F., Albergoni, A., Pennacchi, M., Cerizza, C., Piacentini, M.F., Castagna, A., Galli, L., and Sartor, F. (2023). Failure of Digital Device Performance in Monitoring Physical Exercise in a Pilot Study in Sedentary Persons with HIV. Sensors, 23.","DOI":"10.3390\/s23239461"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1249\/MSS.0000000000002125","article-title":"A Mobile Application for Exercise Intervention in People Living with HIV","volume":"52","author":"Bonato","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40798-019-0214-z","article-title":"The Role of Technology in Adherence to Physical Activity Programs in Patients with Chronic Diseases Experiencing Fatigue: A Systematic Review","volume":"5","author":"Albergoni","year":"2019","journal-title":"Sports Med. Open"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ypmed.2007.04.008","article-title":"Cost-effectiveness of alternative approaches for motivating activity in sedentary adults: Results of Project STRIDE","volume":"45","author":"Sevick","year":"2007","journal-title":"Prev. Med."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/15\/4788\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:22:11Z","timestamp":1760109731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/15\/4788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":38,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["s24154788"],"URL":"https:\/\/doi.org\/10.3390\/s24154788","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,24]]}}}