{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:19:11Z","timestamp":1772727551923,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52175462"],"award-info":[{"award-number":["52175462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFC0105306"],"award-info":[{"award-number":["2016YFC0105306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["52175462"],"award-info":[{"award-number":["52175462"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0105306"],"award-info":[{"award-number":["2016YFC0105306"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Accurate and precise rigid registration between head-neck computed tomography (CT) and cone-beam computed tomography (CBCT) images is crucial for correcting setup errors in image-guided radiotherapy (IGRT) for head and neck tumors. However, conventional registration methods that treat the head and neck as a single entity may not achieve the necessary accuracy for the head region, which is particularly sensitive to radiation in radiotherapy. We propose ACSwinNet, a deep learning-based method for head-neck CT-CBCT rigid registration, which aims to enhance the registration precision in the head region. Our approach integrates an anatomical constraint encoder with anatomical segmentations of tissues and organs to enhance the accuracy of rigid registration in the head region. We also employ a Swin Transformer-based network for registration in cases with large initial misalignment and a perceptual similarity metric network to address intensity discrepancies and artifacts between the CT and CBCT images. We validate the proposed method using a head-neck CT-CBCT dataset acquired from clinical patients. Compared with the conventional rigid method, our method exhibits lower target registration error (TRE) for landmarks in the head region (reduced from 2.14 \u00b1 0.45 mm to 1.82 \u00b1 0.39 mm), higher dice similarity coefficient (DSC) (increased from 0.743 \u00b1 0.051 to 0.755 \u00b1 0.053), and higher structural similarity index (increased from 0.854 \u00b1 0.044 to 0.870 \u00b1 0.043). Our proposed method effectively addresses the challenge of low registration accuracy in the head region, which has been a limitation of conventional methods. This demonstrates significant potential in improving the accuracy of IGRT for head and neck tumors.<\/jats:p>","DOI":"10.3390\/s24165447","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:58:07Z","timestamp":1724417887000},"page":"5447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ACSwinNet: A Deep Learning-Based Rigid Registration Method for Head-Neck CT-CBCT Images in Image-Guided Radiotherapy"],"prefix":"10.3390","volume":"24","author":[{"given":"Kuankuan","family":"Peng","sequence":"first","affiliation":[{"name":"Digital Manufacturing Equipment and Technology Key National Laboratories, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Huagong Manufacturing Equipment Digital National Engineering Center Co., Ltd., Wuhan 430074, China"}]},{"given":"Danyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Digital Manufacturing Equipment and Technology Key National Laboratories, Huazhong University of Science and Technology, Wuhan 430074, China"}]},{"given":"Kaiwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Digital Manufacturing Equipment and Technology Key National Laboratories, Huazhong University of Science and Technology, Wuhan 430074, China"}]},{"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}]},{"given":"Jianchun","family":"Deng","sequence":"additional","affiliation":[{"name":"Digital Manufacturing Equipment and Technology Key National Laboratories, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Huagong Manufacturing Equipment Digital National Engineering Center Co., Ltd., Wuhan 430074, China"}]},{"given":"Shihua","family":"Gong","sequence":"additional","affiliation":[{"name":"Digital Manufacturing Equipment and Technology Key National Laboratories, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Huagong Manufacturing Equipment Digital National Engineering Center Co., Ltd., Wuhan 430074, China"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","first-page":"100590","article-title":"Artificial Intelligence to Predict Outcomes of Head and Neck Radiotherapy","volume":"39","author":"Bang","year":"2023","journal-title":"Clin. 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