{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:07:01Z","timestamp":1787029621529,"version":"3.56.0"},"reference-count":58,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Science Award","award":["#UL\/TR002529"],"award-info":[{"award-number":["#UL\/TR002529"]}]},{"name":"The Advances in Medicine (AIM) grant from Cook Medical","award":["#UL\/TR002529"],"award-info":[{"award-number":["#UL\/TR002529"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Achieving negative surgical margins, defined as no tumor found on the edges of the resected tissue, during lumpectomy for breast cancer is critical for mitigating the risk of local recurrence. To identify nonpalpable tumors that cannot be felt, pre-operative placements of wire and wire-free localization devices are typically employed. Wire-free localization approaches have significant practical advantages over wired techniques. In this study, we introduce an innovative localization system comprising a light-emitting diode (LED)-based implantable device and handheld system. The device, which is needle injectable and wire free, utilizes multiple wirelessly powered LEDs to provide direct visual guidance for lumpectomy. Two distinct colors, red and blue, provide a clear indication of tissue depth: blue light is absorbed strongly in tissue, visible within a close range of &lt;1 cm, while red light remains visible through several centimeters of tissue. The LEDs, integrated with an impedance-matching circuit and receiver coil, are encapsulated in biocompatible epoxy for injection with a 12 G needle. Our findings demonstrate that the implant exhibits clearly perceivable depth-dependent color changes and remains visible through &gt;2 cm of ex vivo chicken breast and bovine muscle tissue using less than 4 W of transmitted power from a handheld antenna. These miniaturized needle-injectable localization devices show promise for improving surgical guidance of nonpalpable breast tumors.<\/jats:p>","DOI":"10.3390\/s24175639","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T07:45:47Z","timestamp":1725003947000},"page":"5639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Wirelessly Powered Visible Light-Emitting Implant for Surgical Guidance during Lumpectomy"],"prefix":"10.3390","volume":"24","author":[{"given":"Sunghoon","family":"Rho","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy A.","family":"Stillwell","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-8550","authenticated-orcid":false,"given":"Kedi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Flavia Borges","family":"de Almeida Barreto","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-4770","authenticated-orcid":false,"given":"Joshua R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA"},{"name":"Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-4978","authenticated-orcid":false,"given":"Patrick","family":"Fay","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M.","family":"Police","sequence":"additional","affiliation":[{"name":"Monument Health Cancer Care Institute, 353 Fairmont Boulevard Rapid City, Rapid City, SD 57701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5121","authenticated-orcid":false,"given":"Thomas D.","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","unstructured":"Hall, M.J., Schwartzman, A., Zhang, J., and Liu, X. 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