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Based on highly sensitive frequency up-conversion detection, large dynamic range spectral measurements in a terahertz region are reported. Our system realized the detection sensitivity at a 10 aJ level with a 2-(3-(4-hydroxystyryl)-5,5-dime-thylcyclohex-2-enylidene) malononitrile (OH1) crystal and a dynamic range up to seven orders. Based on this system, we verified the validity of the spectral measurement with tests which were conducted on monohydrate glucose, anhydrous glucose and mixed tablet samples with a thickness of 0.8 mm in 1~3 THz, respectively. Also, a mini coppery elbow tube with an inner diameter of 1 mm was used for the transmission of a terahertz wave to simulate some strip biological tissue samples. By allowing terahertz to transmit through this tube filled with 0.5 g glucose powder, we successfully obtained the absorption spectrum with a minimum transmittance at the absorption peak in the order of 10\u22124.<\/jats:p>","DOI":"10.3390\/s24196245","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T11:40:27Z","timestamp":1727350827000},"page":"6245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Large Dynamic Range Spectral Measurement in Terahertz Region Based on Frequency Up-Conversion Detection via OH1 Crystal"],"prefix":"10.3390","volume":"24","author":[{"given":"Jiasheng","family":"Yuan","sequence":"first","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"},{"name":"Shandong Provincial Key Laboratory of Laser Technology and Application, School of Information Science and Engineering, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naichang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Laser Technology and Application, School of Information Science and Engineering, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-7104","authenticated-orcid":false,"given":"Xiaoqin","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"},{"name":"School of Foundational Education, University of Health and Rehabilitation Sciences, Qingdao 266071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Ming","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binzhe","family":"Jiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Laser Technology and Application, School of Information Science and Engineering, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-4129","authenticated-orcid":false,"given":"Shuzhen","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laser & Infrared System (Shandong University), Ministry of Education, Qingdao 266237, China"},{"name":"Center for Optics Research and Engineering, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"121107","DOI":"10.1063\/1.3571289","article-title":"Terahertz-frequency photoconductive detectors fabricated from metal-organic chemical vapor deposition-grown Fe-doped InGaAs","volume":"98","author":"Hatem","year":"2011","journal-title":"Appl. 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