{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:27:31Z","timestamp":1760146051512,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["12172204","11772182","11272193","10872121","2019-01-07-00-09-E00018","232102220012"],"award-info":[{"award-number":["12172204","11772182","11272193","10872121","2019-01-07-00-09-E00018","232102220012"]}]},{"name":"Program of Shanghai Municipal Education Commission","award":["12172204","11772182","11272193","10872121","2019-01-07-00-09-E00018","232102220012"],"award-info":[{"award-number":["12172204","11772182","11272193","10872121","2019-01-07-00-09-E00018","232102220012"]}]},{"name":"Key Scientific and Technological Projects in Henan Province","award":["12172204","11772182","11272193","10872121","2019-01-07-00-09-E00018","232102220012"],"award-info":[{"award-number":["12172204","11772182","11272193","10872121","2019-01-07-00-09-E00018","232102220012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The development of numerous diseases, such as renal cyst, cancer, and viral infection, is closely associated with the pathological changes and defects in the cellular peripheral brush. Therefore, it is necessary to develop a potential new method to detect lesions of cellular peripheral brush. Here, a piecewise linear viscoelastic constitutive model of cell is established considering the joint contribution of the peripheral brush and intra-cellular structure. By combining the Laplace transformation and its inverse transformation, and the differential method in the temporal domain and differential quadrature method (DQM) in the spatial domain, the signal interpretation models for quasi-static and dynamic signals of microcantilever are solved. The influence mechanisms of the peripheral brush on the viscoelastic properties of cells and quasi-static\/dynamic signals of microcantilever are clarified. The results not only reveal that the peripheral brush has significant effects on the complex modulus of the cell and multi-channel signals of the microcantilever, but also suggest that an alternative mapping method by collecting multi-channel signals including quasi-static and higher frequency signals with more brush indexes could be potentially used to identify cancerous cells.<\/jats:p>","DOI":"10.3390\/s24196312","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:19:37Z","timestamp":1727680777000},"page":"6312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Channel Signals in Dynamic Force-Clamp Mode of Microcantilever Sensors for Detecting Cellular Peripheral Brush"],"prefix":"10.3390","volume":"24","author":[{"given":"Qiang","family":"Lyu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China"},{"name":"College of Architecture and Civil Engineering, Henan New Environmentally-Friendly Civil Engineering Materials Engineering Research Center, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Pei","sequence":"additional","affiliation":[{"name":"College of Architecture and Civil Engineering, Henan New Environmentally-Friendly Civil Engineering Materials Engineering Research Center, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Architecture and Civil Engineering, Henan New Environmentally-Friendly Civil Engineering Materials Engineering Research Center, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Wei","family":"Ling","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-2865","authenticated-orcid":false,"given":"Neng-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nnano.2009.77","article-title":"Atomic force microscopy detects differences in the surface brush of normal and cancerous cells","volume":"4","author":"Iyer","year":"2009","journal-title":"Nat. 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