{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:57:03Z","timestamp":1784084223607,"version":"3.55.0"},"reference-count":19,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Manganese-zinc-ferrite nanoparticles (Mn0.5Zn0.5Fe2O4, MZF-NPs) prepared by an improved co-precipitation method and were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy dispersive spectrometry (EDS). Then thermodynamic testing of various doses of MZF-NPs was performed in vitro. The cytotoxicity of the Mn0.5Zn0.5Fe2O4 nanoparticles in vitro was tested by the MTT assay. A nanosized As2O3\/Mn0.5Zn0.5Fe2O4 complex was made by an impregnation process. The complex\u2019s shape, component, envelop rate and release rate of As2O3 were measured by SEM, EDS and atom fluorescence spectrometry, respectively. The therapeutic effect of nanosized As2O3\/Mn0.5Zn0.5Fe2O4 complex combined with magnetic fluid hyperthermia (MFH) on human hepatocelluar cells were evaluated in vitro by an MTT assay and flow cytometry. The results indicated that Mn0.5Zn0.5Fe2O4 and nanosized As2O3\/Mn0.5Zn0.5Fe2O4 complex were both prepared successfully. The Mn0.5Zn0.5Fe2O4 nanoparticles had powerful absorption capabilities in a high-frequency alternating electromagnetic field, and had strong magnetic responsiveness. Moreover, Mn0.5Zn0.5Fe2O4 didn\u2019t show cytotoxicity in vitro. The therapeutic result reveals that the nanosized As2O3\/Mn0.5Zn0.5Fe2O4 complex can significantly inhibit the growth of hepatoma carcinoma cells.<\/jats:p>","DOI":"10.3390\/s90907058","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T12:28:24Z","timestamp":1252067304000},"page":"7058-7068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preparation of a Nanosized As2O3\/Mn0.5Zn0.5Fe2O4 Complex and Its Anti-Tumor Effect on Hepatocellular Carcinoma Cells"],"prefix":"10.3390","volume":"9","author":[{"given":"Jia","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Basic Medical Science, Southeast University, Nanjing 210009, China"},{"name":"School of Clinical Medical Science, Southeast University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Southeast University, Nanjing 210009, China"},{"name":"School of Clinical Medical Science, Southeast University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1166\/jnn.2005.219","article-title":"Therapeutic effect of Fe2O3 nanoparticles combined with magnetic fluid hyperthermia on cultured liver cancer cells and xenograft liver cancers","volume":"5","author":"Yan","year":"2005","journal-title":"J. Nanosci. Nanotechnol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/ijc.21557","article-title":"Arsenic trioxide synergizes with B7H3-mediated immunotherapy to eradicate hepatocellular carcinomas","volume":"118","author":"Luo","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1039>3.0.CO;2-D","article-title":"Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of P53 and activation of caspase-3","volume":"91","author":"Jiang","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/jcb.20102","article-title":"Inhibition of cell proliferation and the action mechanisms of Arsenic Trioxide (As2O3) on human breast cancer cells","volume":"93","author":"Chow","year":"2004","journal-title":"J. Cell. 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