{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:57:13Z","timestamp":1776938233911,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T00:00:00Z","timestamp":1252972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 \u03bcm wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio)sensors.<\/jats:p>","DOI":"10.3390\/s90907398","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T11:19:31Z","timestamp":1253013571000},"page":"7398-7411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Chalcogenide Glass Optical Waveguides for Infrared Biosensing"],"prefix":"10.3390","volume":"9","author":[{"given":"Marie-Laure","family":"Anne","sequence":"first","affiliation":[{"name":"Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & C\u00e9ramiques, Universit\u00e9 Rennes 1, 35042 Rennes, France"}]},{"given":"Julie","family":"Keirsse","sequence":"additional","affiliation":[{"name":"Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & C\u00e9ramiques, Universit\u00e9 Rennes 1, 35042 Rennes, France"}]},{"given":"Virginie","family":"Nazabal","sequence":"additional","affiliation":[{"name":"Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & C\u00e9ramiques, Universit\u00e9 Rennes 1, 35042 Rennes, France"}]},{"given":"Koji","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Biomedical sensing and Imaging Group, Inst. for Human Science and Biomedical Engineering, National Institution of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan"}]},{"given":"Satoru","family":"Inoue","sequence":"additional","affiliation":[{"name":"National Institute for Materials Science, 1-1 Namiki, Tsukuba, 305-0041, Japan"}]},{"given":"Catherine","family":"Boussard-Pledel","sequence":"additional","affiliation":[{"name":"Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & C\u00e9ramiques, Universit\u00e9 Rennes 1, 35042 Rennes, France"}]},{"given":"Herv\u00e9","family":"Lhermite","sequence":"additional","affiliation":[{"name":"Institut d\u2019Electronique et de T\u00e9l\u00e9communications de Rennes-Microelectronic, Universit\u00e9 Rennes 1, 35042 Rennes, France"}]},{"given":"Jo\u00ebl","family":"Charrier","sequence":"additional","affiliation":[{"name":"FOTON-CCLO, UMR 6082-ENSSAT, Universit\u00e9 Rennes 1, 22305 Lannion, France"}]},{"given":"Kiyoyuki","family":"Yanakata","sequence":"additional","affiliation":[{"name":"Dept. of Neurosurgery, Inst. of Clinical Medicine, University of Tsukuba, Tsukuba, Japan"}]},{"given":"Olivier","family":"Loreal","sequence":"additional","affiliation":[{"name":"INSERM U522 , IFR 140, University of Rennes 1, Rennes, France"}]},{"given":"Jenny","family":"Le Person","sequence":"additional","affiliation":[{"name":"IFREMER, ERT-Service Interfaces et Capteurs, BP 70 29280 Plouzan\u00e9, France"}]},{"given":"Florent","family":"Colas","sequence":"additional","affiliation":[{"name":"IFREMER, ERT-Service Interfaces et Capteurs, BP 70 29280 Plouzan\u00e9, France"}]},{"given":"Chantal","family":"Comp\u00e8re","sequence":"additional","affiliation":[{"name":"IFREMER, ERT-Service Interfaces et Capteurs, BP 70 29280 Plouzan\u00e9, France"}]},{"given":"Bruno","family":"Bureau","sequence":"additional","affiliation":[{"name":"Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & C\u00e9ramiques, Universit\u00e9 Rennes 1, 35042 Rennes, France"}]}],"member":"1968","published-online":{"date-parts":[[2009,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12529","DOI":"10.1364\/OE.15.012529","article-title":"Infrared single mode chalcogenide glass fibber for space","volume":"15","author":"Houizot","year":"2007","journal-title":"Opt. 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