{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:43:20Z","timestamp":1760985800124,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T00:00:00Z","timestamp":1555804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21761132021"],"award-info":[{"award-number":["21761132021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>In this work we report a convenient asymmetric synthesis of Fmoc-(S)-6,6,6-trifluoro-norleucine via alkylation reaction of chiral glycine equivalent. The target amino acid of 99% enantiomeric purity was prepared with 82.4% total yield (three steps).<\/jats:p>","DOI":"10.3390\/sym11040578","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:02:53Z","timestamp":1555930973000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Convenient Asymmetric Synthesis of Fmoc-(S)-6,6,6-Trifluoro-Norleucine"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-1935","authenticated-orcid":false,"given":"Haibo","family":"Mei","sequence":"first","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China"}]},{"given":"Zizhen","family":"Yin","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China"}]},{"given":"Toshio","family":"Miwa","sequence":"additional","affiliation":[{"name":"Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan"}]},{"given":"Hiroki","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan"}]},{"given":"Hidenori","family":"Abe","sequence":"additional","affiliation":[{"name":"Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-0764","authenticated-orcid":false,"given":"Jianlin","family":"Han","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-4526","authenticated-orcid":false,"given":"Vadim A.","family":"Soloshonok","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV\/EHU, Paseo Manuel Lardiz\u00e1bal 3, 20018 San Sebasti\u00e1n, Spain"},{"name":"IKERBASQUE, Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/acs.jmedchem.7b00318","article-title":"The current state of peptide drug discovery: Back to the future?","volume":"61","author":"Henninot","year":"2018","journal-title":"J. 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