{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:40:48Z","timestamp":1760190048142,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T00:00:00Z","timestamp":1560556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Since the first reports, the Ugi four-component reaction (U-4CR) has been recognized as a keystone transformation enabling the synthesis of peptide mimetics in a single step and with high atom economy. In recent decades, the U-4CR has been a source of inspiration for many chemists fascinated by the possibility of identifying new efficient organic reactions by simply changing one of the components or by coupling in tandem the multicomponent process with a huge variety of organic transformations. Herein we review the synthetic potentialities, the boundaries, and the applications of the U-4CR involving \u03b1-amino acids, where the presence of two functional groups\u2014the amino and the carboxylic acids\u2014allowed a 5-center 4-component Ugi-like reaction, a powerful tool to gain access to drug-like multi-functionalized scaffolds.<\/jats:p>","DOI":"10.3390\/sym11060798","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T03:24:41Z","timestamp":1560741881000},"page":"798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["\u03b1-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications"],"prefix":"10.3390","volume":"11","author":[{"given":"Sveva","family":"Pelliccia","sequence":"first","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia Antonella","family":"Alfano","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldina","family":"Galli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienza del Farmaco, Universit\u00e0 del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Novellino","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-414X","authenticated-orcid":false,"given":"Mariateresa","family":"Giustiniano","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-400X","authenticated-orcid":false,"given":"Gian Cesare","family":"Tron","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienza del Farmaco, Universit\u00e0 del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U","article-title":"Multicomponent reactions with isocyanides","volume":"39","author":"Ugi","year":"2000","journal-title":"Angew. 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