{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:52:00Z","timestamp":1760241120658,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Today, gene transfer using polymers as transfer vectors is hardly studied. Some polymers have an excellent gene-carrying ability, but their cytotoxic and biocompatibility properties are not suitable for use. Thus, increased insight into the drug space of such structures is needed in the screening for suitable molecules. This study aimed to introduce a mathematical model of polymers suitable for genes transfer. In this regard, Riemann surfaces were used. The concerned polymers were taken from secondary published experimental data. The results show that symmetric Reimann spaces are suitable for further drug screening. The branch point values of Riemann surfaces are especially increased for the polymers suitable in gene transfer.<\/jats:p>","DOI":"10.3390\/sym11121466","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:50:45Z","timestamp":1575283845000},"page":"1466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Riemann-Symmetric-Space-Based Models in Screening for Gene Transfer Polymers"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-3142","authenticated-orcid":false,"given":"Claudiu N.","family":"Lungu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 400028 Cluj, Romania"}]},{"given":"Ireneusz P.","family":"Grudzinski","sequence":"additional","affiliation":[{"name":"Department of Applied Toxicology, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1021\/acs.molpharmaceut.9b00959","article-title":"Molecular engineering of Adeno-associated virus capsid improves its therapeutic gene transfer in murine models of hemophilia and retinal degeneration","volume":"16","author":"Mary","year":"2019","journal-title":"Mol. 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