{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:40:34Z","timestamp":1761676834616,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["No. N161608001"],"award-info":[{"award-number":["No. N161608001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013071","name":"Major Program of National Fund of Philosophy and Social Science of China","doi-asserted-by":"publisher","award":["NO. 18ZD23"],"award-info":[{"award-number":["NO. 18ZD23"]}],"id":[{"id":"10.13039\/501100013071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30770594"],"award-info":[{"award-number":["30770594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["2008AA02Z405"],"award-info":[{"award-number":["2008AA02Z405"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>The human brain is approximately a symmetric structure, although the functional brain does not exhibit symmetry. Functional brain aging process modelling is essential for the understanding of hypothesized generative mechanisms for human brain networks throughout one\u2019s lifespan. We present a novel generative network model of the human functional brain network, which is the hybrid of the local na\u00efve Bayes model and the anatomical similarity correction (LNBE). We use LNBE, as well as published generative network models to simulate the aging process of the functional brain network, to construct artificial brain networks and to reveal the generative mechanisms and evolutionary patterns of human functional brain across human lifespans. It is suggested that the idea of classifying common neighbours while considering anatomical distances during network formation can provide a much more similar generative mechanism of the human fMRI brain aging process as well as a more practical generative network model of it. We hold that studies on brain normal aging process modelling have the potential to improve the way in which early warnings for latent injury or disease are practised today and advance healthcare.<\/jats:p>","DOI":"10.3390\/sym12010091","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T11:55:07Z","timestamp":1578052507000},"page":"91","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Generative Network Model of the Human Brain Normal Aging Process"],"prefix":"10.3390","volume":"12","author":[{"given":"Xiao","family":"Liu","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Northeastern University, Shenyang 110000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-1221","authenticated-orcid":false,"given":"Shuaizong","family":"Si","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Northeastern University, Shenyang 110000, China"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Northeastern University, Shenyang 110000, China"}]},{"given":"Hai","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Northeastern University, Shenyang 110000, China"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Northeastern University, Shenyang 110000, China"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1515\/revneuro-2017-0051","article-title":"Accelerated aging and aging process in the brain","volume":"29","author":"Isaev","year":"2018","journal-title":"Rev. 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