{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:24:07Z","timestamp":1774470247363,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K20730"],"award-info":[{"award-number":["16K20730"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>This study was aimed at clarifying the effect of different levels of state anxiety caused by mental arithmetic tasks on the anxiety- and\/or task performance-related activation of the frontopolar prefrontal cortex (PFC). Twenty-six healthy male subjects performed two sets of mental arithmetic tasks, which consisted of two difficulty levels. Anxiety levels were evaluated subjectively by the State\u2013Trait Anxiety Inventory-Form JYZ (STAI). Near-infrared spectroscopy (NIRS) measurements revealed greater levels of oxyhemoglobin in the frontopolar PFC during experimental tasks. When the subjects were divided into three anxiety groups based on STAI scores, arithmetic task performance was reduced in the moderate and high state anxiety groups compared the low state anxiety group during the experimental task, but not in the control task. Increased frontopolar PFC activity during the experimental task was observed on either side in the moderate anxiety group. The laterality of frontopolar PFC activity in moderate and high state anxiety groups shifted from left to right dominance, independent of task difficulty. Our findings suggested that reduced task performance increased the difficulty of the arithmetic tasks and was involved in the state anxiety-associated rightward lateralization of the frontopolar PFC.<\/jats:p>","DOI":"10.3390\/sym12040538","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T03:40:19Z","timestamp":1586403619000},"page":"538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rightward Shift of Two-Channel NIRS-Defined Prefrontal Cortex Activity during Mental Arithmetic Tasks with Increasing Levels of State Anxiety"],"prefix":"10.3390","volume":"12","author":[{"given":"Miwa","family":"Horiuchi-Hirose","sequence":"first","affiliation":[{"name":"Department of Nursing, Ibaraki Christian University, Hitachi, Ibaraki 319-1295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-1041","authenticated-orcid":false,"given":"Kazuhiko","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki 300-0051, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/13154","article-title":"In vivo evidence for post-adolescent brain maturation in frontal and striatal regions","volume":"2","author":"Sowell","year":"1999","journal-title":"Nat. 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