{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:16:39Z","timestamp":1760235399427,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR Sheffield Biomedical Research Centre","award":["IS-BRC-1215-20017"],"award-info":[{"award-number":["IS-BRC-1215-20017"]}]},{"name":"Horizon 2020","award":["IMI22017-13-7-820820"],"award-info":[{"award-number":["IMI22017-13-7-820820"]}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/K03877X\/1","EP\/S032940\/1"],"award-info":[{"award-number":["EP\/K03877X\/1","EP\/S032940\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Pathological gait is often associated with a lack of symmetry. A possible way to quantify this feature is to use acceleration data measured by a sensor located on the lower trunk. The most common approach calculates a symmetry index starting from the autocorrelation function, aiming to measure the divergence in motion of the left and right sides of the body. The various methods proposed to implement this approach are based on nonlinear and discontinuous functions, and the interpretation of their output is far from straightforward. The aim of this study was to propose a linear and easier to interpret quantification measure for gait asymmetry. The proposed measure was tested on data from healthy controls and from patients with Multiple Sclerosis and Parkinson\u2019s Disease, and it was shown to negate the flaws present in previous methods and to provide more directly interpretable results.<\/jats:p>","DOI":"10.3390\/sym13091560","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T23:25:50Z","timestamp":1629933950000},"page":"1560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Proposal for a Linear Calculation of Gait Asymmetry"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4124-2052","authenticated-orcid":false,"given":"Linda Maria Adriana","family":"van Gelder","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Insigneo Institute for In Silico Medicine, The University of Sheffield, Sheffield S10 2TN, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-7717","authenticated-orcid":false,"given":"Lorenza","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Insigneo Institute for In Silico Medicine, The University of Sheffield, Sheffield S10 2TN, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-6286","authenticated-orcid":false,"given":"Ellen E.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Insigneo Institute for In Silico Medicine, The University of Sheffield, Sheffield S10 2TN, UK"}]},{"given":"Claudia","family":"Mazz\u00e0","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Insigneo Institute for In Silico Medicine, The University of Sheffield, Sheffield S10 2TN, UK"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bspc.2018.01.013","article-title":"Gait symmetry measures: A review of current and prospective methods","volume":"42","author":"Viteckova","year":"2018","journal-title":"Biomed. 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Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s00415-020-09928-8","article-title":"Wearable sensors can reliably quantify gait alterations associated with disability in people with progressive multiple sclerosis in a clinical setting","volume":"267","author":"Angelini","year":"2020","journal-title":"J. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cohen, J. (1977). CHAPTER 3\u2014The Significance of a Product Moment rs. Statistical Power Analysis for the Behavioral Sciences, Academic Press.","DOI":"10.1016\/B978-0-12-179060-8.50008-6"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3389\/fnhum.2016.00625","article-title":"Accelerometer-based step regularity is lower in older adults with bilateral knee osteoarthritis","volume":"10","author":"Barden","year":"2016","journal-title":"Front. Hum. 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