{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:31:41Z","timestamp":1762918301966,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundar","award":["UIDB\/04567\/2020 UIDP\/ 04567\/2020"],"award-info":[{"award-number":["UIDB\/04567\/2020 UIDP\/ 04567\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>The significance of lower limb perfusion asymmetries remains unknown in healthy individuals. Our study aims to understand how factors such as posture, sex, age, and body weight relate to perfusion. Data from studies previously published by our group, including experiments using laser Doppler flowmetry as the gold standard for perfusion measurements in baseline, (various) challenge, and recovery phases was assembled from a total of 139 healthy participants. Body position was shown to be a primary determinant of perfusion asymmetry, especially in women. Effects of sex and age were also analyzed. In a supine position, perfusion asymmetries seemed to relate negatively in the aged group of participants, where challenge and recovery seemed to follow different processes. In the upright position, young men and women have shown comparable distributions and asymmetry ratios at baseline and recovery. In the aged group, differences between sexes were observed at baseline, but again, the course of the asymmetry ratios with challenge was essentially similar in men and women. Our analysis suggests that ageing is a critical determinant in our upright study sample, as higher baseline asymmetries and longer recoveries after challenge were linked in older males with higher body mass index (BMI).<\/jats:p>","DOI":"10.3390\/sym13122348","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T02:48:13Z","timestamp":1638845293000},"page":"2348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lower Limb Perfusion Asymmetries in Humans at Rest and Following Activity\u2014A Collective View"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-7671","authenticated-orcid":false,"given":"Luis Monteiro","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Research Center for Biosciences and Health Technologies, Universidade Lus\u00f3fona CBIOS, Campo Grande, 376, 1749-024 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente Gomes","family":"Rocha","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences and Health Technologies, Universidade Lus\u00f3fona CBIOS, Campo Grande, 376, 1749-024 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2466-6942","authenticated-orcid":false,"given":"Margarida Esteves","family":"Florindo","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences and Health Technologies, Universidade Lus\u00f3fona CBIOS, Campo Grande, 376, 1749-024 Lisboa, Portugal"},{"name":"Department Physiotherapy, ESSCVP\u2014The Portuguese Red Cross Health School, 1749-024 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-9453","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Greg\u00f3rio","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences and Health Technologies, Universidade Lus\u00f3fona CBIOS, Campo Grande, 376, 1749-024 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"ref_1","first-page":"517","article-title":"Claudication Intermittent des Membres Posterieurs, determinee par L\u2019obliteration des Arteres Femorales","volume":"8","author":"Bouley","year":"1831","journal-title":"Recl. 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