{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:42:53Z","timestamp":1774986173151,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Boron neutron capture therapy (BNCT) is a binary type of radiotherapy for the treatment of cancer. Due to recent developments of neutron accelerators and their installation in some hospitals, BNCT is on the rise worldwide and is expected to have a significant impact on patient treatments. Therefore, there is an increasing need for improved boron delivery agents. Among the many small molecules and delivery systems developed, a significant amount of recent research focused on the synthesis of boron-containing sugar and amino acid derivatives to exploit specific transport proteins, as d-glucose transporter 1 (GLUT1) and large neutral amino acid transporter (LAT1), overexpressed by tumor cells. This review will discuss the last year\u2019s achievements in the synthesis and some biological evaluation of boronated sugars derivatives. The compounds described in this review are intrinsically asymmetric due to the presence of chiral sugar moieties, often joined to boron clusters, which are structural elements with high symmetry.<\/jats:p>","DOI":"10.3390\/sym14020182","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T22:47:32Z","timestamp":1642546052000},"page":"182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Sweet Boron: Boron-Containing Sugar Derivatives as Potential Agents for Boron Neutron Capture Therapy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-1439","authenticated-orcid":false,"given":"Daniela","family":"Imperio","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 del Piemonte Orientale, L.go Donegani 2, 28100 Novara, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-0409","authenticated-orcid":false,"given":"Luigi","family":"Panza","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 del Piemonte Orientale, L.go Donegani 2, 28100 Novara, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"ref_1","first-page":"666","article-title":"Biological Effects and Therapeutic Possibilities of Neutrons","volume":"36","author":"Locher","year":"1936","journal-title":"Am. 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