{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:03:40Z","timestamp":1784343820511,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["21-17211S"],"award-info":[{"award-number":["21-17211S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["21-32608S"],"award-info":[{"award-number":["21-32608S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007655","name":"Czech Technical University in Prague","doi-asserted-by":"publisher","award":["SGS20\/172\/OHK3\/3T\/13"],"award-info":[{"award-number":["SGS20\/172\/OHK3\/3T\/13"]}],"id":[{"id":"10.13039\/100007655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012825","name":"International Visegrad Fund","doi-asserted-by":"publisher","award":["52110300"],"award-info":[{"award-number":["52110300"]}],"id":[{"id":"10.13039\/100012825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Graph-theoretical approaches are increasingly used to study the brain and may enhance our understanding of its asymmetries. In this paper, we hypothesize that the structure of the left hemisphere is, on average, more modular. To this end, we analyzed resting-state functional magnetic resonance imaging data of 90 healthy subjects. We computed functional connectivity by Pearson\u2019s correlation coefficient, turned the matrix into an unweighted graph by keeping a certain percentage of the strongest connections, and quantified modularity separately for the subgraph formed by each hemisphere. Our results show that the left hemisphere is more modular. The result is consistent across a range of binarization thresholds, regardless of whether the two hemispheres are thresholded together or separately. This illustrates that graph-theoretical analysis can provide a robust characterization of lateralization of brain functional connectivity.<\/jats:p>","DOI":"10.3390\/sym14040833","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:22:43Z","timestamp":1650414163000},"page":"833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Brain Functional Connectivity Asymmetry: Left Hemisphere Is More Modular"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-3826","authenticated-orcid":false,"given":"Lucia","family":"Jajcay","sequence":"first","affiliation":[{"name":"National Institute of Mental Health, 250 67 Klecany, Czech Republic"},{"name":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, 182 07 Prague, Czech Republic"},{"name":"Faculty of Electrical Engineering, Czech Technical University in Prague, 166 27 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-0529","authenticated-orcid":false,"given":"David","family":"Tome\u010dek","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, 250 67 Klecany, Czech Republic"},{"name":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, 182 07 Prague, Czech Republic"},{"name":"Faculty of Electrical Engineering, Czech Technical University in Prague, 166 27 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-7306","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Hor\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, 250 67 Klecany, Czech Republic"},{"name":"Department of Psychiatry, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-696X","authenticated-orcid":false,"given":"Filip","family":"\u0160paniel","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, 250 67 Klecany, Czech Republic"},{"name":"Department of Psychiatry, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-1470","authenticated-orcid":false,"given":"Jaroslav","family":"Hlinka","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, 250 67 Klecany, Czech Republic"},{"name":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, 182 07 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/physrev.00006.2019","article-title":"Brain lateralization: A comparative perspective","volume":"100","author":"Ocklenburg","year":"2020","journal-title":"Physiol. 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