{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:09:00Z","timestamp":1760227740978,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research on Teaching Innovative Team of National Vocational Education Teachers of the Second Group in Ministry of Education","award":["ZI2021100105","22A230019"],"award-info":[{"award-number":["ZI2021100105","22A230019"]}]},{"name":"Key Scientific and Research Projects of Colleges and Universities of Henan Province","award":["ZI2021100105","22A230019"],"award-info":[{"award-number":["ZI2021100105","22A230019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>The current study was conducted to investigate effects of hydroxyselenomethionine (HMBSe) with symmetrical and chelated chemical structure, a novel organic selenium (Se) source, on lactation performance, anti-oxidative status and immunities, and transfer efficiencies for early lactation dairy cows compared with that of sodium selenite (SS). Forty-five multiparous early-lactating dairy cows with similar days in milk, 56.0 d and milk yield 36.1 kg\/d, were fed with same basal diet containing 0.04 mg of Se\/kg of dry matter (DM) basis. They were assigned to 1 of 3 treatments according to one-way ANOVA design: control (basal diet, without Se supplementation), SS (0.30 mg of Se\/kg of DM), or HMBSe (0.30 mg of Se\/kg of DM). The experiment lasted for 9 weeks, with the first week as adaptation. Results showed that the organic HMBSe cows increased the milk yield, 4% fat-corrected milk yield, the numbers of red blood cells in whole blood, Se concentrations in milk and serum, ratio of milk to serum significantly (P &lt; 0.01); feed efficiency, energy-corrected milk yield, contents of superoxide dismutase in serum, hemoglobin, and the numbers of white blood cells in whole blood significantly (P &lt; 0.05) compared to control and SS. Moreover, HMBSe cows had trends to increase glutathione peroxidase activities (P = 0.09), total antioxidant capacity (P = 0.06), and had trends to decrease the contents of malonaldehyde (P = 0.07) in serum compared to control and SS. In conclusion, HMBSe was more effective on the lactation performances, anti-oxidative status, and immunities and Se transfer efficiencies for early-lactating dairy cows compared to control and SS, which was very meaningful to develop the enriched Se milk products.<\/jats:p>","DOI":"10.3390\/sym14050916","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T08:21:25Z","timestamp":1651652485000},"page":"916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Hydroxyselenomethionine with Symmetrical and Chelated Chemical Structure on Lactation Performances, Anti-Oxidative Status and Immunities, Selenium Transfer Efficiencies for Early-Lactating Dairy Cows"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-3530","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Husbandry Engineering, Henan Vocational College of Agriculture, Zhengzhou 451450, China"}]},{"given":"Weixian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China"}]},{"given":"Hualin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Agricultural College, Xiangyang Polytechnic, Xiangyang 441050, China"}]},{"given":"Jinfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Animal Husbandry Engineering, Henan Vocational College of Agriculture, Zhengzhou 451450, China"}]},{"given":"Chunmei","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3168\/jds.2008-1545","article-title":"Meta-analysis of the effect of oral selenium supplementation on milk selenium concentration in cattle","volume":"92","author":"Ceballos","year":"2009","journal-title":"J. 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