{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:26:55Z","timestamp":1769200015332,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Operational Program \u201cIntegrated Infrastructure\u201d of the project \u201cIntegrated strategy in the development of personalized medicine of selected malignant tumor diseases and its impact on life quality\u201d","award":["313011V446"],"award-info":[{"award-number":["313011V446"]}]},{"name":"Operational Program \u201cIntegrated Infrastructure\u201d of the project \u201cIntegrated strategy in the development of personalized medicine of selected malignant tumor diseases and its impact on life quality\u201d","award":["VEGA 1\/0643\/17"],"award-info":[{"award-number":["VEGA 1\/0643\/17"]}]},{"name":"Operational Program \u201cIntegrated Infrastructure\u201d of the project \u201cIntegrated strategy in the development of personalized medicine of selected malignant tumor diseases and its impact on life quality\u201d","award":["APVV-15-0751"],"award-info":[{"award-number":["APVV-15-0751"]}]},{"name":"European Regional Development Fund","award":["313011V446"],"award-info":[{"award-number":["313011V446"]}]},{"name":"European Regional Development Fund","award":["VEGA 1\/0643\/17"],"award-info":[{"award-number":["VEGA 1\/0643\/17"]}]},{"name":"European Regional Development Fund","award":["APVV-15-0751"],"award-info":[{"award-number":["APVV-15-0751"]}]},{"name":"Slovak Research and Development Agency","award":["313011V446"],"award-info":[{"award-number":["313011V446"]}]},{"name":"Slovak Research and Development Agency","award":["VEGA 1\/0643\/17"],"award-info":[{"award-number":["VEGA 1\/0643\/17"]}]},{"name":"Slovak Research and Development Agency","award":["APVV-15-0751"],"award-info":[{"award-number":["APVV-15-0751"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>RBC (Red Blood Cell) membrane is a highly elastic structure, and proper modelling of this elasticity is essential for biomedical applications that involve computational experiments with blood flow. In this work, we present a new method for estimating one of the key parameters of red blood cell elasticity, which uses a neural network trained on the simulation outputs. We test classic LSTM (Long-Short Term Memory) architecture for the time series regression task, and we also experiment with novel CNN-LSTM (Convolutional Neural Network) architecture. We paid special attention to investigating the impact of the way the three-dimensional training data are reduced to their two-dimensional projections. Such a comparison is possible thanks to working with simulation outputs that are equivalently defined for all dimensions and their combinations. The obtained results can be used as recommendations for an appropriate way to record real experiments for which the reduced dimension of the acquired data is essential.<\/jats:p>","DOI":"10.3390\/sym14081732","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T01:56:40Z","timestamp":1661133400000},"page":"1732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Computational Study of Methods for Determining the Elasticity of Red Blood Cells Using Machine Learning"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-7484","authenticated-orcid":false,"given":"Samuel","family":"Mol\u010dan","sequence":"first","affiliation":[{"name":"Department of Software Technology, Faculty of Management Science and Informatics, University of \u017dilina, 010 26 \u017dilina, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3633-1798","authenticated-orcid":false,"given":"Monika","family":"Smie\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Software Technology, Faculty of Management Science and Informatics, University of \u017dilina, 010 26 \u017dilina, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-488X","authenticated-orcid":false,"given":"Hynek","family":"Bachrat\u00fd","sequence":"additional","affiliation":[{"name":"Department of Software Technology, Faculty of Management Science and Informatics, University of \u017dilina, 010 26 \u017dilina, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5510-5585","authenticated-orcid":false,"given":"Katar\u00edna","family":"Bachrat\u00e1","sequence":"additional","affiliation":[{"name":"Department of Software Technology, Faculty of Management Science and Informatics, University of \u017dilina, 010 26 \u017dilina, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100092","DOI":"10.1016\/j.talo.2022.100092","article-title":"Microfluidic platforms for the manipulation of cells and particles","volume":"5","author":"Afsaneh","year":"2022","journal-title":"Talanta Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"907232","DOI":"10.3389\/fbioe.2022.907232","article-title":"Application of Microfluidics in Detection of Circulating Tumor Cells","volume":"10","author":"Li","year":"2022","journal-title":"Front. 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