{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:23:03Z","timestamp":1775704983444,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Koltzov Institute of Developmental Biology of the Russian Academy of Sciences","award":["0088-2021-0019"],"award-info":[{"award-number":["0088-2021-0019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Developmental noise is a variety that is not related to the usually distinguished sources of phenotypic diversity, i.e., differences in the genotype and in the environment. This variation arises in the process of the realization of genetic information and reflects the imperfection of ontogenetic processes. The most common measure of it is the value of fluctuating asymmetry as slight deviations from the symmetry. Developmental noise proves to be one of the main sources of intrapopulation phenotypic diversity. The magnitude of this variability is an ontogenetic response to environmental or genetic stress, and its assessment, in fact, provides a unique opportunity to estimate the developing system condition. The level of developmental noise, characterizing an organism\u2019s condition, acts as another population parameter that allows to approach the evaluation of the community condition. Initial deviations in the system condition can be detected even against the background of optimal estimates of abundance, biodiversity, and ecosystem functioning.<\/jats:p>","DOI":"10.3390\/sym14112380","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T01:39:54Z","timestamp":1668130794000},"page":"2380","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Developmental Noise and Biological System Condition: Prolegomena"],"prefix":"10.3390","volume":"14","author":[{"given":"Vladimir M.","family":"Zakharov","sequence":"first","affiliation":[{"name":"Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 26 Vavilov Street, Moscow 119334, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-1361","authenticated-orcid":false,"given":"Ilya E.","family":"Trofimov","sequence":"additional","affiliation":[{"name":"Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 26 Vavilov Street, Moscow 119334, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","unstructured":"Waddington, C.H. 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