{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:48:13Z","timestamp":1760150893735,"version":"build-2065373602"},"reference-count":78,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008394","name":"Fundaci\u00f3 Bosch i Gimpera funds","doi-asserted-by":"publisher","award":["FBG 300412"],"award-info":[{"award-number":["FBG 300412"]}],"id":[{"id":"10.13039\/501100008394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>The topological partition theory states that icosahedral group affine extensions (fullerenes symmetry) are the most effective way to energetically optimize the surface covering. In recent decades, potential applications of fullerene symmetry have emerged in the major fields of biology, like enzyme inhibition and antiviral therapy. This research suggests a novel perspective to interpret the underlying spatial organization of cell populations in tissues from the polyhedral graph theory. We adopted this theoretical framework to study HUVEC cell in vitro angiogenesis assays on Matrigel. This work underscores the importance of extracellular Ca2+ gradients, both from conditioned BJ and pretreated HUVEC cells, in angiogenesis fullerene-rule spatial minimization.<\/jats:p>","DOI":"10.3390\/sym16010055","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T06:37:12Z","timestamp":1704004632000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Calcium and Fullerene Symmetry Spatial Minimization on Angiogenesis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-4408","authenticated-orcid":false,"given":"Manuel","family":"Rivas","sequence":"first","affiliation":[{"name":"Celltec-UB, Department of Cell Biology, Physiology and Immunology, University of Barcelona, Av\/Diagonal, 643, 08028 Barcelona, Spain"},{"name":"Departament d\u2019Enginyeria Qu\u00edmica, Barcelona East School of Engineering, Universitat Polit\u00e8cnica de Catalunya, C\/Eduard Maristany, 10-14, 08930 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0701-200X","authenticated-orcid":false,"given":"Manuel","family":"Reina","sequence":"additional","affiliation":[{"name":"Celltec-UB, Department of Cell Biology, Physiology and Immunology, University of Barcelona, Av\/Diagonal, 643, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: Therapeutic implications","volume":"285","author":"Folkmann","year":"1971","journal-title":"N. 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