{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:10:26Z","timestamp":1773889826964,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>Homochirality, the ubiquitous preference of biological molecules, such as amino acids, sugars, and phospholipids, for a single enantiomeric form, is a fundamental characteristic of life. This consistent bias across the biosphere, where proteins predominantly utilize L-amino acids and nucleic acids predominantly utilize D-sugars, is not merely a biochemical peculiarity but a crucial aspect of life\u2019s molecular architecture. However, the origin of this homochirality remains one of the most compelling and unresolved mysteries in the study of life\u2019s origins, drawing inquiry from fields as diverse as cosmology, physics, chemistry, and biology. This article provides an overview of chirality\u2019s pervasive influence across these domains, tracing its potential origins from early Earth\u2019s conditions to its pivotal role in shaping both natural phenomena and the technological advancements that define our future.<\/jats:p>","DOI":"10.3390\/sym17030473","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:25:00Z","timestamp":1742541900000},"page":"473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Homochirality Emergence: A Scientific Enigma with Profound Implications in Origins of Life Studies"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8176-9249","authenticated-orcid":false,"given":"Michele","family":"Fiore","sequence":"first","affiliation":[{"name":"ICBMS\u2014UMR5246, Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires, Universit\u00e9 de Lyon, Claude Bernard Lyon 1, 69100 Villeurbanne, France"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1089\/ast.2023.0007","article-title":"The Origin and Early Evolution of Life: Homochirality Emergence in Prebiotic Environments","volume":"23","author":"Chieffo","year":"2023","journal-title":"Astrobiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0094-5765(00)00024-2","article-title":"Chirality and the Origin of Life","volume":"46","author":"Bailey","year":"2000","journal-title":"Acta Astronaut."},{"key":"ref_3","first-page":"174","article-title":"Prebiotic Chemistry: Common Origins of Glycerol, Amino Acids, and Pyrimidines, and Cosmic Origin of Nature\u2019s Enantiomeric Excess of Amino Acids. 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