{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:29:27Z","timestamp":1774078167912,"version":"3.50.1"},"reference-count":76,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["12275179"],"award-info":[{"award-number":["12275179"]}]},{"name":"National Natural Science Foundation of China","award":["21ZR1443900"],"award-info":[{"award-number":["21ZR1443900"]}]},{"name":"Natural Science Foundation of Shanghai","award":["12275179"],"award-info":[{"award-number":["12275179"]}]},{"name":"Natural Science Foundation of Shanghai","award":["21ZR1443900"],"award-info":[{"award-number":["21ZR1443900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"<jats:p>In mammals, the suprachiasmatic nucleus (SCN), located in the hypothalamus serves as the master biological clock and precisely regulates circadian rhythms through a complex network structure. As a central pacemaker, the SCN has two primary functions: one is to synchronize the daily rhythms in physiological and behavioral activities; the other is to entrain the endogenous rhythms to the external light\u2013dark cycle. A deep understanding of the SCN network structure is crucial for elucidating the functional mechanisms of the biological clock system. In this review, we systematically summarized the impact of the SCN network structure on functional regulation under light stimulation based on mathematical models. Studies have shown that the coupling between the light-sensitive subgroups in the left and right nuclei of the SCN can enhance the entrainment ability. As an integrated network structure, the SCN may have the characteristics of the small-world network or the scale-free network, as these properties are more conducive to the realization of functions. Additionally, the higher-order coupling mechanism within the SCN can effectively expand the entrainment range. These theoretical research results offer new insights into the relationship between the SCN network and functions and provide crucial theoretical guidance and validation directions for subsequent experimental research.<\/jats:p>","DOI":"10.3390\/sym17091418","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T13:27:44Z","timestamp":1756733264000},"page":"1418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Model Research on the Influence of the Biological Clock Network Structure on Function Under Light Stimulation"],"prefix":"10.3390","volume":"17","author":[{"given":"Jing","family":"Feng","sequence":"first","affiliation":[{"name":"Higher Vocational and Technical College, Shanghai University of Engineering Science, Shanghai 200437, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Business School, University of Shanghai for Science and Technology, Shanghai 200093, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgui","family":"Gu","sequence":"additional","affiliation":[{"name":"Business School, University of Shanghai for Science and Technology, Shanghai 200093, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrn1177","article-title":"A clockwork web: Circadian timing in brain and periphery, in health and disease","volume":"4","author":"Hastings","year":"2003","journal-title":"Nat. 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