{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:48:46Z","timestamp":1760057326500,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"March of Dimes Birth Defects Foundation","award":["SPO 249650"],"award-info":[{"award-number":["SPO 249650"]}]},{"name":"Christopher Hess Research Fund","award":["SPO 249650"],"award-info":[{"award-number":["SPO 249650"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Systems"],"abstract":"<jats:p>Preeclampsia is a form of gestational hypertension that usually appears after the 20th week of pregnancy. Evidence suggests that low-dose aspirin (LDA) effectively reduces the risk of developing preeclampsia, but the uptake rate remains low. This scoping review aims to synthesize and integrate existing knowledge domains relevant to the factors that influence women\u2019s medication decisions during pregnancy, and to develop a causal explanation for at-risk women\u2019s LDA uptake decisions. We introduced systems thinking to map the variables and develop causal loops to show variable interactions and causal explanations guided by the Theory of Planned Behavior. We extracted 65 variables, and grouped them into provider- (n = 19), patient- (n = 39), and system-level (n = 7) factors. By identifying variable interactions, we built a theory to explain various causal pathways leading to LDA treatment uptake. Mapping the variables and supporting the relationships of these variables with theories and concepts increases our study\u2019s generalizability to medication decisions for other pregnancy complications.<\/jats:p>","DOI":"10.3390\/systems13020086","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T04:05:47Z","timestamp":1738296347000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Evidence and Causal Mapping of Factors Which Influence Medication-Taking Behavior of Pregnant Women at Risk of Hypertensive Disorder: A Scoping Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-5684","authenticated-orcid":false,"given":"Yin Jien","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Taft","sequence":"additional","affiliation":[{"name":"School of Humanities and Sciences, Stanford University, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1829-8553","authenticated-orcid":false,"given":"Melody","family":"Moua","sequence":"additional","affiliation":[{"name":"School of Humanities and Sciences, Stanford University, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-5824","authenticated-orcid":false,"given":"Gary L.","family":"Darmstadt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"f6564","DOI":"10.1136\/bmj.f6564","article-title":"Pre-eclampsia Rates in the United States, 1980\u20132010: Age-period-cohort Analysis","volume":"347","author":"Ananth","year":"2013","journal-title":"BMJ"},{"key":"ref_2","unstructured":"CDC (2023, January 24). \u201cPregnancy Mortality Surveillance System\u201d. 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