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Key themes include AI-driven business model innovation, human\u2013AI collaboration, ethical governance, operational efficiency, customer experience personalization, organizational capability development, and adoption disparities. AI enables scalable product development, personalized service delivery, and data-driven strategic decisions. Successful implementations hinge on overcoming technical, cultural, and ethical barriers, with ethical AI adoption enhancing consumer trust and competitiveness, positioning responsible innovation as a strategic imperative. For practitioners, this review offers evidence-based frameworks for aligning AI with business objectives. For academics, it identifies research frontiers, including longitudinal impacts, context-specific roadmaps for small- and medium-sized enterprises, and sustainable innovation pathways. This review conceptualizes AI as a driver of systemic organizational transformation, requiring continuous learning, ethical foresight, and strategic ability for competitive advantage.<\/jats:p>","DOI":"10.3390\/systems13040264","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:05:02Z","timestamp":1744110302000},"page":"264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Impacts of Artificial Intelligence on Business Innovation: A Comprehensive Review of Applications, Organizational Challenges, and Ethical Considerations"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-6677","authenticated-orcid":false,"given":"Ruben","family":"Machucho","sequence":"first","affiliation":[{"name":"Information Technologies Program, Polytechnic University of Victoria, Ciudad Victoria 87138, Tamaulipas, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6715-0535","authenticated-orcid":false,"given":"David","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Business Administration and Management Program, Polytechnic University of Victoria, Ciudad Victoria 87138, Tamaulipas, Mexico"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1257\/aer.20160696","article-title":"The race between man and machine: Implications of technology for growth, factor shares, and employment","volume":"108","author":"Acemoglu","year":"2018","journal-title":"Am. 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