{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:25:50Z","timestamp":1764480350669,"version":"3.46.0"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"T.T. acknowledges the Indian National Science Academy"},{"DOI":"10.13039\/100008900","name":"University of South Florida","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008900","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Systems"],"abstract":"<jats:p>From Galileo\u2019s conviction that the Universe is written in the language of mathematics to the genomic and computational revolutions of the twentieth century, science has long sought to describe nature through external symbolic systems. However, mounting evidence across biology, physics, and cognitive science suggests that this reduction of semantics to syntax is insufficient. Life cannot be deterministically read only from DNA sequences, cognition cannot be reduced to just rule-based logic, and complex systems exhibit emergent behaviors that transcend symbolic description. We argue that these phenomena point toward an underappreciated principle, \u201cthe intelligence of matter\u201d, whereby organized material systems inherently process information, adapt, and remember. Examples span from protein allostery and epigenetic memory to epitranscriptomic regulation, intelligent soft matter, and ecological reservoir computing. In these cases, computation emerges not from imposed codes but from the intrinsic dynamics of matter that is far from equilibrium. Recognizing intelligence as a general property of organized matter may inaugurate a new scientific style: one that deciphers the semantics of nature rather than superimposing ours and thus reshaping the epistemology of modern science.<\/jats:p>","DOI":"10.3390\/systems13121072","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:56:02Z","timestamp":1764323762000},"page":"1072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intelligence of Matter: Rise of a New Style of Doing Science and Scientific Thinking?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-289X","authenticated-orcid":false,"given":"Timir","family":"Tripathi","sequence":"first","affiliation":[{"name":"Molecular and Structural Biophysics Laboratory, Department of Zoology, School of Life Sciences, North-Eastern Hill University, Shillong 793022, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-5857","authenticated-orcid":false,"given":"Vladimir N.","family":"Uversky","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and USF Health Byrd Alzheimer\u2019s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-804X","authenticated-orcid":false,"given":"Alessandro","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Environment and Health Department, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Roma, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","unstructured":"Galilei, G. 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