{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:46:05Z","timestamp":1760237165771,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["14\/23547-8"],"award-info":[{"award-number":["14\/23547-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The objective of this study was to characterize oligofructose-induced acute rumen lactic acidosis and its consequences in zebu cattle. We used 29 Nellore heifers which were submitted to experimental induction of laminitis by oligofructose excess. During the induction period, the animals underwent clinical examination, including laminitis diagnosis (hoof pressure testing and locomotion score) and blood and ruminal fluid sampling every six hours (over the initial 24 h) and every 12 h (up to 72 h), after the highest dose. Almost half of the animals (48.1%) required treatment with bicarbonate and saline to correct metabolic acidosis and dehydration. Due to this treatment, the animals were analyzed in treated (n = 13) and non-treated (n = 14) groups. The induction model promoted marked reduction in rumen pH, rumen anaerobiosis, carbon dioxide pressure, and increase in rumen lactate, blood osmolarity, and cortisol concentration. The animals treated had lower values of rumen pH and marked dehydration, evidenced by the increase in globular volume and serum urea. The clinical condition caused by excess oligofructose is severe, with the differential of the appearance of ephemeral fever and respiratory compensation against systemic acidosis, in addition to the frequent appearance of laminitis.<\/jats:p>","DOI":"10.3390\/ani10030429","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T10:46:08Z","timestamp":1583318768000},"page":"429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Oligofructose-Induced Acute Rumen Lactic Acidosis and the Appearance of Laminitis in Zebu Cattle"],"prefix":"10.3390","volume":"10","author":[{"given":"Rejane dos Santos","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. Prof. Orlando Marques de Paiva, 87, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-270, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Leonardo Costa de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. Prof. Orlando Marques de Paiva, 87, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-270, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3201-391X","authenticated-orcid":false,"given":"Mailson Rennan Borges","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. Prof. Orlando Marques de Paiva, 87, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-270, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia Sato","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. Prof. Orlando Marques de Paiva, 87, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-270, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo do","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. Prof. Orlando Marques de Paiva, 87, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-270, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Aparecida Alves dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. Prof. Orlando Marques de Paiva, 87, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-270, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-6129","authenticated-orcid":false,"given":"Raimundo Alves","family":"Barr\u00eato J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Federal Rural University of the Semiarid Region (UFERSA). Av. Francisco Mota, s\/n\u00ba\u2014Bairro Pres. Costa e Silva, Mossor\u00f3 CEP 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3652","authenticated-orcid":false,"given":"Antonio Humberto Hamad","family":"Minervino","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Health (LARSANA), Federal University of Western Par\u00e1 (UFOPA) Rua Vera Paz, s\/n, Sal\u00e9, Santar\u00e9m CEP 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico Lippi","family":"Ortolani","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP). Av. 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