{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:01:46Z","timestamp":1788807706785,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T00:00:00Z","timestamp":1583625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872318, 31601923"],"award-info":[{"award-number":["31872318, 31601923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Agriculture and Rural Affairs Joint Projects for the National High Quality and Lean Pig Breeding","award":["19190540"],"award-info":[{"award-number":["19190540"]}]},{"name":"Key Project for Jiangsu Agricultural New Variety Innovation","award":["PZCZ201732"],"award-info":[{"award-number":["PZCZ201732"]}]},{"name":"Construction of Huaian Academy of Nanjing Agricultural University","award":["BM2017020"],"award-info":[{"award-number":["BM2017020"]}]},{"name":"Project of Jiangsu Agricultural (pig) Industry Technology System","award":["JATS(2019)418, JATS(2019)189)"],"award-info":[{"award-number":["JATS(2019)418, JATS(2019)189)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Rice bran is a waste product with low cost and high fiber content, giving it an added advantage over corn and soybean meal, which have to be purchased and always at a relatively higher cost. Under the background of increased attention to sustainable agriculture, it is significant to find alternative uses for this byproduct. A total of 35 finishing pigs were allotted to five dietary treatments: a control group with basal diet and four experimental diets where corn was equivalently substituted by 7%, 14%, 21%, and 28% defatted rice bran (DFRB), respectively. With increasing levels of DFRB, the neutrophil to lymphocyte ratio (NLR) linearly decreased (p &lt; 0.05). In the jejunum, the mRNA level of nuclear factor erythroid-2 related factor-2 (Nrf2) exhibited a quadratic response (p &lt; 0.01) with incremental levels of DFRB. In the colon, the mRNA levels of mucin 2 (MUC2), Nrf2, and NAD(P)H: quinone oxidoreductase 1 (NQO1) were upregulated (linear, p &lt; 0.05) and heme oxygenase-1 (HO-1) was upregulated (linear, p &lt; 0.01). Overall, using DFRB to replace corn decreased the inflammatory biomarkers of serum and showed potential function in modulating the intestinal barrier by upregulating the mRNA expression levels of MUC2 and downregulating that of Nrf2, NQO1, and HO-1 in the colon.<\/jats:p>","DOI":"10.3390\/ani10030449","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T05:37:34Z","timestamp":1583732254000},"page":"449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Defatted Rice Bran Supplementation in Diets of Finishing Pigs: Effects on Physiological, Intestinal Barrier, and Oxidative Stress Parameters"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-0676","authenticated-orcid":false,"given":"Lijuan","family":"Fan","sequence":"first","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-2271","authenticated-orcid":false,"given":"Ruihua","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"},{"name":"Industrial Technology System Integration Innovation Center of Jiangsu Modern Agriculture (PIG), Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwu","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoran","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Pu","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuduo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Industrial Technology System Integration Innovation Center of Jiangsu Modern Agriculture (PIG), Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghua","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Huaian Academy, Nanjing Agricultural University, Huaian 223003, China"},{"name":"Industrial Technology System Integration Innovation Center of Jiangsu Modern Agriculture (PIG), Nanjing 210095, China"},{"name":"Nanjing Agricultural University\u2019s New Rural Research and Development Corporation of Huaian City, Huaian 223003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3382\/ps.2012-02373","article-title":"Future considerations in poultry nutrition","volume":"91","author":"Leeson","year":"2012","journal-title":"Poult. 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