{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:48:36Z","timestamp":1761709716395,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31760650"],"award-info":[{"award-number":["31760650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial Key Projects of Shaanxi","award":["2014KTDZ02-01"],"award-info":[{"award-number":["2014KTDZ02-01"]}]},{"name":"National Scientific and Technological Innovation Project of Undergraduate of Northwest A&amp;F University","award":["201910712070"],"award-info":[{"award-number":["201910712070"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The SRY-type HMG box 9 (Sox9) gene plays an important role in chondrocyte development as well as changes in hypertrophic chondrocytes, indicating that Sox9 can regulate growth in animals. However, no studies to date have examined the correlation between variations in Sox9 and growth traits in goats. Here, we found a 4 bp indel in the 3\u2032UTR of Sox9 and verified its association with growth traits in Shaanbei white cashmere goats (n = 1109). The frequencies of two genotypes (ID and II) were 0.397 and 0.603, respectively, and polymorphic information content (PIC) values showed that the indel had a medium PIC (PIC &gt; 0.25). The 4 bp indel was significantly correlated with body length (p = 0.006), heart girth (p = 0.001), and hip width (p = 4.37 \u00d7 10 \u22124). Notably, individuals with the ID genotype had significantly superior phenotypic traits compared with individuals bearing the II genotype. Hence, we speculated that the 4 bp indel is an important mutation affecting growth traits in goat, and may serve as an effective DNA molecular marker for marker-assisted selection in goat breeding programs.<\/jats:p>","DOI":"10.3390\/ani10040672","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T10:41:52Z","timestamp":1586774512000},"page":"672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Detection of a 4 bp Mutation in the 3\u2032UTR Region of Goat Sox9 Gene and Its Effect on the Growth Traits"],"prefix":"10.3390","volume":"10","author":[{"given":"Libang","family":"He","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University, Yangling 712100, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University, Yangling 712100, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruolan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University, Yangling 712100, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanying","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University, Yangling 712100, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University, Yangling 712100, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyong","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University, Yangling 712100, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qu","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, Shaanxi, China"},{"name":"Life Science Research Center, Yulin University, Yulin 719000, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.gendis.2014.09.004","article-title":"The versatile functions of Sox9 in development, stem cells, and human diseases","volume":"1","author":"Jo","year":"2014","journal-title":"Genes Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1038\/s41467-018-07784-9","article-title":"Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9","volume":"9","author":"Croft","year":"2018","journal-title":"Nat. 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