{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:01:37Z","timestamp":1790272897898,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PEI\/CONACyT 2015\/ 220311"],"award-info":[{"award-number":["PEI\/CONACyT 2015\/ 220311"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Synbiotic consumption can modulate immune response. This work involves studying the effect of a synbiotic on lymphoid organs and IgA of broilers infected with Salmonella typhimurium and Clostridium perfringens. A total of 258 one-day-old male broilers (Gallus gallus domesticus), line COBBAvian48 (free of growth-promoting antibiotics), were distributed into eight treatment groups. A symbiotic mix comprising Lactobacillus rhamnosus HN001 and Pediococcus acidilactici MA18\/5 M as probiotics and 4.5% (0.045 g g\u22121) of Agave tequilana fructans as prebiotic per dose (one milliliter) was administered through drinking water the first day of life. Bursa, spleen and thymus were analyzed. Broilers treated with the synbiotic, whether or not infected with pathogens, had bigger bursa follicles than the non-treated (p &lt; 0.05), and the ones from the synbiotic group had more lymphocytes than the control group (p &lt; 0.05). Thymus follicles of the synbiotic group were bigger than the control group (p &lt; 0.05). Lesions associated with Salmonella infection were found in the bursa, however, in the broilers treated with the synbiotic, the lesions were less intense and were not present after 32 days of life. The synbiotic mix can stimulate the bursa, increasing the size of their follicles and promoting the ability to resist infections caused by S. typhimurium in broilers.<\/jats:p>","DOI":"10.3390\/ani10050886","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T02:48:24Z","timestamp":1589942904000},"page":"886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of a Synbiotic Mix on Lymphoid Organs of Broilers Infected with Salmonella typhimurium and Clostridium perfringens"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-5407","authenticated-orcid":false,"given":"Zuam\u00ed","family":"Villagr\u00e1n-de la Mora","sequence":"first","affiliation":[{"name":"Departamento de Ciencias de la Salud, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitl\u00e1n de Morelos 47620, Jalisco, Mexico"},{"name":"Centro de Investigaciones Biol\u00f3gicas del Noroeste (CIBNOR), Av. Instituto Polit\u00e9cnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz 23096, BCS, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"V\u00e1zquez-Paulino","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Blvd. Gral. Marcelino Garc\u00eda Barrag\u00e1n 1421, Ol\u00edmpica, Guadalajara 44430, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Avalos","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Blvd. Gral. Marcelino Garc\u00eda Barrag\u00e1n 1421, Ol\u00edmpica, Guadalajara 44430, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ascencio","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas del Noroeste (CIBNOR), Av. Instituto Polit\u00e9cnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz 23096, BCS, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Nu\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Nuevo Perif. Ote. 555, Ejido San Jos\u00e9 Tateposco, Tonal\u00e1 45425, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3458-1221","authenticated-orcid":false,"given":"Ang\u00e9lica","family":"Villarruel-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Nuevo Perif. Ote. 555, Ejido San Jos\u00e9 Tateposco, Tonal\u00e1 45425, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.56808\/2985-1130.2722","article-title":"Effect of antibiotic growth promoters on anti-oxidative and anti-inflammatory activities in broiler chickens","volume":"46","author":"Kabploy","year":"2016","journal-title":"Thai J. Vet. 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