{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:22:05Z","timestamp":1760239325172,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Blood transfusion reactions and neonatal isoerythrolysis are common events in the feline population due to the presence of natural alloantibodies in the AB blood group system. It is known that the frequency of feline blood types varies according to the geographic region and breed. Therefore, the aims of this study were to investigate the frequency of AB blood groups in non-pedigree domestic cats in Central Italy and estimate the risk of a life-threatening transfusion reaction and neonatal isoerythrolysis, caused by mismatched transfusion or incompatible random mating, respectively. The AB blood group was determined on non-pedigree domestic feline patients and potential blood donors submitted at the Veterinary Teaching Hospitals of the Universities of Teramo (Abruzzo Region, Teramo, Italy) and Perugia (Umbria Region, Teramo, Italy), and visited at veterinary practitioners in Rome (Lazio Region, Teramo, Italy) using commercial immunochromatographic cartridges and commercial agglutination cards. There were four hundred and eighty-three cats included in the study. The frequencies of the blood types were: 89.9% type A, 7.0% type B, and 3.1% type AB. The probability of an acute hemolytic transfusion reaction or a neonatal isoerythrolysis was 6.5%. Although the frequency of type B in non-pedigree domestic cats living in Central Italy was relatively low, to reduce the risk of fatal transfusion reactions, blood group typing is recommended before each transfusion.<\/jats:p>","DOI":"10.3390\/ani10101937","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T20:51:00Z","timestamp":1603399860000},"page":"1937","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frequency of Blood Types A, B and AB in a Population of Non-Pedigree Domestic Cats from Central Italy"],"prefix":"10.3390","volume":"10","author":[{"given":"Morena Di","family":"Tommaso","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-6298","authenticated-orcid":false,"given":"Arianna","family":"Miglio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, 06100 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Emidio","family":"Crisi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Boari","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rocconi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Antognoni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, 06100 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Luciani","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"ref_1","first-page":"425","article-title":"Updates on practical ABC blood compatibility testing in cats","volume":"47","author":"Kehl","year":"2019","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref_2","first-page":"209","article-title":"Blood groups in cats in the city of Zagreb","volume":"86","author":"Karadjole","year":"2016","journal-title":"Vet. Arh."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/BF03548338","article-title":"Distribution of feline blood types detected in the Copenhagen area of Denmark","volume":"35","author":"Jensen","year":"1994","journal-title":"Acta Vet. Scand."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1748-5827.2007.00325.x","article-title":"Frequencies of feline blood types at a referral hospital in the south east of England","volume":"48","author":"Forcada","year":"2007","journal-title":"J. Small Anim. Pract."},{"key":"ref_5","unstructured":"Giger, U., Gorman, N.T., Hubler, M., Leidinger, J.I., Leidinger, E.F., and Lubas, G. (1992, January 3\u20137). Frequencies of feline type A and B blood types in Europe. Proceedings of the 23rd Conference of the International Society of Animal Genetics, Interlaken, Switzerland."},{"key":"ref_6","first-page":"235","article-title":"Frequency of feline blood types in non-pedigree cats in France","volume":"168","author":"Barrot","year":"2017","journal-title":"Revue M\u00e9d. V\u00e9t."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nectoux, A., Guidetti, M., Barth\u00e9lemy, A., Pouzot-Nevoret, C., Hoareau, G.L., and Goy-Thollot, I. (2019). Assessment of risks of feline mismatched transfusion and neonatal isoerythrolysis in the Lyon (France) area. J. Feline Med. Surg. Open Rep., 5.","DOI":"10.1177\/2055116919863175"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kehl, A., Heimberger, K., Langbein-Detsch, I., Boehmer, S., Raj, K., Mueller, E., and Giger, U. (2018). Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping scheme. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204287"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/vr.149.7.213","article-title":"Determination of the prevalence of blood types in the non-pedigree feline population in Greece","volume":"149","author":"Mylonakis","year":"2001","journal-title":"Vet. Rec."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1556\/004.49.2001.4.1","article-title":"Frequencies of feline blood types in Hungary","volume":"49","author":"Bagdi","year":"2001","journal-title":"Acta Vet. Hung."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Vieira, S.M., Ferreira, R.R.F., de Matos, A.J., Cardoso, I.M., Gra\u00e7a, R.M.C., Soares, A.R., Blasi-Brugu\u00e9, C., S\u00e1nchez, I.M., and Gopegui, R.R. (2017). Distribution of feline AB blood types: A review of frequencies and its implications in the Iberian Peninsula. J. Feline Med. Surg. Open Rep., 3.","DOI":"10.1177\/2055116917727693"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/vr.c6879","article-title":"Assessment of feline blood for transfusion purposes in the Dublin area of Ireland","volume":"168","author":"Juvet","year":"2011","journal-title":"Vet. Rec."},{"key":"ref_13","unstructured":"Cavana, P., Picco, S., Bellino, C., and Farca, A.M. (2007, January 2\u20134). Distribuzione dei gruppi sanguigni nei gatti della regione Piemonte (Italia). Proceedings of the 55 Congresso Nazionale SCIVAC-SIMEF. Medicina Felina. Le Nuove Acquisizioni Nella Pratica Clinica, Milan, Italy. (In Italian)."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1939-165X.2011.00286.x","article-title":"Comparison of gel column agglutination with monoclonal antibodies and card agglutination methods for assessing the feline AB group system and a frequency study of feline blood types in northern Italy","volume":"40","author":"Proverbio","year":"2011","journal-title":"Vet. Clin. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"704836","DOI":"10.1155\/2014\/704836","article-title":"Signalment and blood types in cats being evaluated as blood donors at two italian university blood banks","volume":"2014","author":"Spada","year":"2014","journal-title":"Vet. Med. Int."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Spada, E., Perego, R., Baggiani, L., Salatino, E., Priolo, V., Mangano, C., Pennisi, M.G., and Proverbio, D. (2020). Prevalence of Blood Types and Alloantibodies of the AB Blood Group System in Non-Pedigree Cats From Northern (Lombardy) and Southern (Sicily) Italy. Animals, 10.","DOI":"10.3390\/ani10071129"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1939-165X.2004.tb00380.x","article-title":"Frequencies of feline blood types in northern Portugal","volume":"33","author":"Pastor","year":"2004","journal-title":"Vet. Clin. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1939-165X.2011.00303.x","article-title":"Frequency of blood type A, B, and AB in 515 domestic shorthair cats from the Lisbon area","volume":"40","author":"Marques","year":"2011","journal-title":"Vet. Clin. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/vr.154.25.794","article-title":"Survey of feline blood types in the Barcelona area of Spain","volume":"154","author":"Velasquez","year":"2004","journal-title":"Vet. Rec."},{"key":"ref_20","first-page":"778","article-title":"Blood types in the non-pedigree cat population of Gran Canaria","volume":"155","author":"Pastor","year":"2004","journal-title":"Vet. Rec."},{"key":"ref_21","first-page":"231","article-title":"[The blood group distribution in domestic cats in Switzerland]","volume":"135","author":"Hubler","year":"1993","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1748-5827.2006.00005.x","article-title":"Frequencies of blood type A, B and AB in non-pedigree domestic cats in Turkey","volume":"47","author":"Arikan","year":"2006","journal-title":"J. Small Anim. Pract."},{"key":"ref_23","first-page":"322","article-title":"Frequencies of Blood Type A, B and AB in cats from the Mediterranean Sea Coast of the Turkey","volume":"161","author":"Arikan","year":"2010","journal-title":"Revue M\u00e9d. V\u00e9t."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1748-5827.1999.tb03051.x","article-title":"Determination of the prevalence of feline blood types in the UK","volume":"40","author":"Knottenbelt","year":"1999","journal-title":"J. Small Anim. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/jsap.12180","article-title":"Feline blood genotyping versus phenotyping, and detection of non-AB blood type incompatibilities in UK cats","volume":"55","author":"Tasker","year":"2014","journal-title":"J. Small Anim. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1439-0442.2003.00536.x","article-title":"Blood Type A and B Frequencies in Turkish Van and Angora Cats in Turkey","volume":"50","author":"Arikan","year":"2003","journal-title":"J. Vet. Med. A"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/vcp.12048","article-title":"Assessment of blood types of Ragdoll cats for transfusion purposes","volume":"42","author":"Proverbio","year":"2013","journal-title":"Vet. Clin. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1177\/1098612X14567549","article-title":"Haematological and biochemical reference intervals in adult Maine Coon cat blood donors","volume":"17","author":"Spada","year":"2015","journal-title":"J. Feline Med. Surg."},{"key":"ref_29","first-page":"49","article-title":"Natural infection of Anaplasma platys in dogs from Umbria region (Central Italy)","volume":"50","author":"Antognoni","year":"2014","journal-title":"Vet Ital."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.vetmic.2018.08.030","article-title":"Detection of parvovirus and herpesvirus DNA in the blood of feline and canine blood donors","volume":"224","author":"Marenzoni","year":"2018","journal-title":"Vet. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/1098612X17727233","article-title":"Comparison of three blood transfusion guidelines applied to 31 feline donors to minimise the risk of transfusion-transmissible infections","volume":"20","author":"Marenzoni","year":"2018","journal-title":"J. Feline Med. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/jhered\/82.1.15","article-title":"Frequency and inheritance of A and B blood types in feline breeds of the United States","volume":"82","author":"Giger","year":"1991","journal-title":"J. Hered."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/age.12778","article-title":"CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats","volume":"50","author":"Kehl","year":"2019","journal-title":"Anim. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0195-5616(95)50156-1","article-title":"Feline transfusion medicine. Blood types and their clinical importance","volume":"25","author":"Giger","year":"1995","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1748-5827.1999.tb03101.x","article-title":"Measurement of titres of naturally occurring alloantibodies against feline blood group antigens in the UK","volume":"40","author":"Knottenbelt","year":"1999","journal-title":"J. Small Anim. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jfms.2005.03.003","article-title":"Titres of alloantibodies against A and B blood types in non-pedigree domestic cats in Turkey: Assessing the transfusion reaction risk","volume":"7","author":"Gurkan","year":"2005","journal-title":"J. Feline Med. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2460\/ajvr.1996.57.11.1653","article-title":"Transfer of colostral antibodies from queens to their kittens","volume":"57","author":"Casal","year":"1996","journal-title":"Am. J. Vet. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0195-5616(99)50077-6","article-title":"Fading kitten syndrome and neonatal isoerythrolysis","volume":"29","year":"1999","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1939-1676.2007.tb02962.x","article-title":"A Newly Recognized Blood Group in Domestic Shorthair Cats: The Mik Red Cell Antigen","volume":"21","author":"Weinstein","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/jvim.15334","article-title":"Prevalence of naturally occurring non-AB blood type incompatibilities in cats and influence of crossmatch on transfusion outcomes","volume":"32","author":"McClosky","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/vec.12360","article-title":"Evaluation of an Immunochromatographic Test for Feline AB System Blood Typing","volume":"26","author":"Spada","year":"2016","journal-title":"J. Vet. Emerg. Crit. Care"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/10\/10\/1937\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:25:31Z","timestamp":1760178331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/10\/10\/1937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["ani10101937"],"URL":"https:\/\/doi.org\/10.3390\/ani10101937","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2020,10,21]]}}}