{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:16:13Z","timestamp":1783973773833,"version":"3.55.0"},"reference-count":94,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["Project 2017-00946 and Project 2019-00288"],"award-info":[{"award-number":["Project 2017-00946 and Project 2019-00288"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["Project 2015-05919"],"award-info":[{"award-number":["Project 2015-05919"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["IJDC-2015-24380"],"award-info":[{"award-number":["IJDC-2015-24380"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["FI_B 00236"],"award-info":[{"award-number":["FI_B 00236"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU15\/06029"],"award-info":[{"award-number":["FPU15\/06029"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["20780\/PD\/18"],"award-info":[{"award-number":["20780\/PD\/18"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Rabbits are interesting as research animal models for reproduction, due to their condition of species of induced ovulation, with the release of endogenous gonadotropin-releasing hormone (GnRH) due to coitus. Glucocorticoid (GC) signaling, crucial for physiological homeostasis, is mediated through a yet unclear mechanism, by the GC receptor (NR3C1\/GR). After mating, the female reproductive tract undergoes dynamic modifications, triggered by gene transcription, a pre-amble for fertilization and pregnancy. This study tested the hypothesis that when ovulation is induced, the expression of NR3C1 is influenced by sperm-free seminal plasma (SP), similarly to after mating (whole semen), along the different segments of the internal reproductive tract of female rabbits. Semen (mating) was compared to vaginal infusion of sperm-free SP (Experiment 1), and changes over time were also evaluated, i.e., 10, 24, 36, 68, and 72 h post-mating, corresponding to specific stages, i.e., ovulation, fertilization, and the interval of early embryo development up to the morula stage (Experiment 2). All does were treated with GnRH to induce ovulation. Samples were retrieved from seven segments of the reproductive tract (from the cervix to infundibulum), at 20 h post-mating or sperm-free SP infusion (Experiment 1) or at 10, 24, 36, 68, and 72 h post-mating (Experiment 2). Gene expression of NR3C1 was analyzed by qPCR. Results showed an increase in NR3C1 expression in the infundibulum compared to the other anatomical regions in the absence of spermatozoa when sperm-free SP infusion was performed (Experiment 1). Moreover, during the embryo transport through the oviduct, the distal isthmus was time-course upregulated, especially at 72 h, when morulae are retained in this anatomical region, while it was downregulated in the distal uterus at 68 h (Experiment 2). The overall results suggest that NR3C1, the GC receptor gene, assessed in the reproductive tract of does for the first time, shows differential expression changes during the interval of oviductal and uterine embryo transport that may imply a relevant role of the GC action, not only close to the site of ovulation and fertilization, but also in the endometrium.<\/jats:p>","DOI":"10.3390\/ani10112158","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T10:46:26Z","timestamp":1605782786000},"page":"2158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Seminal Plasma Triggers the Differential Expression of the Glucocorticoid Receptor (NR3C1\/GR) in the Rabbit Reproductive Tract"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-7993","authenticated-orcid":false,"given":"Mateo","family":"Ruiz-Conca","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (BKV), Division of Children\u2019s and Women Health (BKH), Obstetrics and Gynecology, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"},{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-2088","authenticated-orcid":false,"given":"Jaume","family":"Gardela","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (BKV), Division of Children\u2019s and Women Health (BKH), Obstetrics and Gynecology, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"},{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-7734","authenticated-orcid":false,"given":"Amaia","family":"Jauregi-Miguel","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (BKV), Division of Molecular Medicine and Virology (MMV), Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6811-0191","authenticated-orcid":false,"given":"Cristina A.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (BKV), Division of Children\u2019s and Women Health (BKH), Obstetrics and Gynecology, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-2124","authenticated-orcid":false,"given":"Heriberto","family":"Rodr\u00edguez-Martinez","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (BKV), Division of Children\u2019s and Women Health (BKH), Obstetrics and Gynecology, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"L\u00f3pez-B\u00e9jar","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-354X","authenticated-orcid":false,"given":"Manuel","family":"Alvarez-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (BKV), Division of Children\u2019s and Women Health (BKH), Obstetrics and Gynecology, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"},{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0587.2008.05532.x","article-title":"Breeding like rabbits: Global patterns of variability and determinants of European wild rabbit 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